The formation of α-methylated and α,α-dimethylated (di)acids during on-line (trans)methylation with tetramethylammonium hydroxide (TMAH) in a Curie-point pyrolysis unit is studied. The reaction of TMAH with nonanedioic, hexadecanedioic and octadecanoic acids is investigated to determine the c...

State-dependent learning (SDL) is a phenomenon in which the retrieval of newly acquired information is possible if the subject is in the same physiological state as during the encoding phase. SDL makes it possible to separate the effects of drugs per se on learning from the effects due to change...

Maprotiline, a new tetracyclic antidepressant, has a pattern of toxicity that is different from that of tricyclics. Maprotiline overdosage appears more likely to cause seizures but less likely to cause the peripheral autonomic and cardiac manifestations seen with tricyclics. Two cases of maproti...

The synthesis of a diverse library of compounds structurally related to maprotiline, a norepinephrine reuptake transporter (NET) selective antidepressant which has recently been identified as a novel in vitro antiproliferative agent against Burkitt's lymphoma (BL) cell lines is reported. A ...

Antidepressant drugs are commonly used for treatment of different medical disorders besides of psychiatric diseases. Accumulating evidence suggests that antidepressants exhibit anti-inflammatory activity in vivo and in vitro conditions, but the mechanisms of this property are not clear very well...

Publisher SummaryThis chapter discusses maprotiline hydrochloride. Maprotiline hydrochloride occurs as a white to off-white, odorless, fine, crystalline powder. Maprotiline hydrochloride is polymorphic and known to exhibit several crystal forms. A typical production batch is a mixture with varyi...

There are two series of novel thermotropic liquid crystalline polyurethanes (LCPUs), obtained from the polyaddition reaction of 4,4′-bis(ω-hydroxyalkoxy) biphenyls (HBn, n: the number of methylene units in hydroxyalkoxy group) with 1,3-bis(isocyanatomethyl) benzene (XDI) and 1,3-bis(isocyanato...

The molecular geometry, vibrational frequencies, gauge-including atomic orbital (GIAO) 1H and 13C chemical shift values of 3,5-bis-(4-methylbenzoyl)-2,6-bis(4-methylphenyl)-4H-pyran-4-one in the ground state have been calculated by using the Hartree–Fock (HF) and density functional method (DFT/...

In this work two novel rare-earth (RE) 3-(4-methylbenzoyl)-propanoate (mbp) complexes (RE(mbp)3; RE = La, Y) have been investigated and compared with the well-researched inhibitor, lanthanum 4-hydroxycinnamate (La(4-OHcin)3), for AS1020 mild steel in 0.01 M NaCl solutions. The electrochemical re...

Racemic N-substituted -1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols containing cis-4a-aralkyl groups were explored as probes for opioid receptors. Specifically cis-4a-phenylpropyl, -phenylbutyl, and-phenylpentyl groups coupled with widely varied substituents on the nitrogen atom were syn...

A new synthesis of N-methyl and N-phenethyl substituted ortho-c and para-c oxide-bridged phenylmorphans, using N-benzyl- rather than N-methyl-substituted intermediates, was used and the pharmacological properties of these compounds were determined. The N-phenethyl substituted ortho-c oxide-bridg...

Two of the 12 possible oxide-bridged phenylmorphans, were synthesized, rac-(3R,6aS,11aS)-2-methyl-1,3,4,5,6,11a-hexahydro-2H-3,6a-methanobenzofuro[2,3-c]azocine-10-ol (7) (the ortho-c compound), and rac-(3R,6aS,11aS)-2-methyl-1,3,4,5,6,11a-hexahydro-2H-3,6a-methanobenzofuro[2,3-c]azocine-8-ol (8...

Magnetic nanoparticles possess numerous potential applications, e.g., hyperthermia, magnetic resonance imaging (MRI), catalytic applications, etc. Decomposition of iron pentacarbonyl is one of the most common methods for preparation of magnetic iron oxide and iron nanoparticles. However, Fe(CO)5...

The xylidine 2,4-dimethylaniline (2,4-DMA) produces hepatic cholangiofibrosis, bile duct proliferation, and foci of cellular hyperplasia and degeneration in the rat. The same compound is relatively innocuous in the dog. 2,6-Dimethylaniline (2,6-DMA) does not produce hepatic lesions in the rat, e...

In acetonitrile, the tren-N-tricalix[4]arene 4 with three appended pyrenyl groups showed an enhanced fluorescence in the presence of Al3+ and, to a lesser extent, of In3+. Compound 4 was shown to form a 1:1 complex with Al3+, the metal cation being located in the tren part. The association const...

Propofol (2,6-diisopropylphenol) is commonly used as an anaesthetic agent but is also abused for recreational purposes. Several cases of fatalities involving self-administered propofol have been reported. For rapid quantification of propofol and propofol β-d-glucuronide (propofol G) in clinical...

The purposes of this study were to develop a HPLC method to assay for haloperidol glucuronide (HALG); to apply this assay method to the in vitro determination of haloperidol (HAL) UDP-glucuronosyltransferase (UGT) enzyme kinetics in rat liver microsomes (RLM); and to identify the UGT isoforms ca...

New derivatives of 5a,6-dihydro-12H-indolo[2,1-b][1,3]benzoxazine and 1′,3,3′,4-tetrahydrospiro[chromene-2,2′-indole] that possess trifluoromethyl groups on the indoline part of the molecule were synthesised, and their potential application for the detection of cyanide was evaluated. It was d...

Here we report a green synthesis of ZnSe quantum dots (QDs) in aqueous solution of polyampholyte chitosan derivative – N-(2-carboxyethyl)chitosan (CEC) with substitution degrees (DS) from 0.7 to 1.3 and molecular weight (MW) of 40 kDa and 150 kDa. We have shown that the maximum intensity of pho...

Identification and localization of modifications in peptides containing multiple disulfide bonds is challenging due to inefficient fragmentation in mass spectrometry (MS) analysis. In cases where MS fragmentation techniques such as electron capture dissociation (ECD), electron transfer dissociat...