The syntheses of oxazolyl functionalized polymers using 4,5-dihydro-4,4-dimethyl-2-[4-(1-phenylethenyl)phenyl]oxazole in atom transfer radical polymerization (ATRP) reactions are reported. A new oxazolyl initiator system was generated in situ by the atom transfer radical addition (ATRA) reaction...

A diphenylanthracene-based diamidine (1a) fluorescent probe for the detection of dicarboxylic acids has been designed and synthesized, which has an extended π-conjugation rather than a simple anthracene ring, in order to observe highly different fluorescence wavelengths after complex formation ...

In this study, we report the synthesis and anti-proliferative effect of a set of eight androst-4-ene-3-one derivatives with different arylcarbamoyl groups at C-17. The novel compounds were prepared from commercially available 3β-hydroxy-5-pregnen-20-one and evaluated against the androgen-sensit...

A series of novel thiazolo derivatives 2–17 were synthesized by initial condensation of methyl 2-(thiazol-2-ylcarbamoyl)acetate 1 with phenyl isothiocyanate and further reactions using different organic reagents. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, EIMS s...

In this paper, we report the synthesis of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothiourea derivatives (4a-y) carrying active pharmacophores essential for anticonvulsant activity. The anticonvulsant activity was evaluated in vivo by maximal electroshock...

This work is a continuation and extension of previously published study on the conversions of oil palm empty fruit bunch and mesocarp fiber biomass to levulinic acid and ethyl levulinate via an eco-friendly indium trichloride-1-methylimidazolium hydrogen sulfate (Tiong et al., 2017). Herein, a r...

Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and Gram-negative bacteria. A ...

Humic acids are natural components of organic matter widespread in the environment. In spite of the incomplete knowledge about their composition, increasing interest in humic acid activity is justified by their ubiquity. Four different humic acids have been tested in Chinese hamster ovary cells ...

In present study, a series of novel 1,3,4-oxadiazole derivatives have been designed, synthesized and purified. All of these compounds are reported for the first time, the chemical structures of these compounds were confirmed by means of 1H NMR, ESI-MS and elemental analyses. Besides, we evaluate...

The classic fixed-dose combination (FDC) of 4 tuberculosis drugs, namely rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol dihydrochloride (EDH) has the twin issues of physical stability and RIF cross-reaction in the 4-FDC. The major reason for these quality issues is the int...

Fossil fuels are still one of the world’s major sources of energy. Because of their reduced availability in the future, however, renewable resources like biodiesel provide an attractive substitute to meet the growing demand for energy supply. Significant problems associated with the use of biod...

The flame-retardant rigid polyurethane foams (RPUFs) with [bis(2-hydroxyethyl)amino]-methyl-phosphonic acid dimethyl ester (BH)/expandable graphite (EG) were prepared via box-foaming in our laboratory. The flame retardancy of RPUFs with BH and EG was characterized using the limiting oxygen index...

The molecular characteristics of different vermicomposts, produced with variable rates of cattle manure and cotton residues, and of related humic acids were determined by 13C-CPMAS NMR and Off-line pyrolysis THM-GC–MS. The analyses highlighted a composition of mature vermicomposts based on diff...

A structure-based medicinal chemistry optimization was conducted on the clinical Hsp90 inhibitor diarylisoxazole 3. Several series of new compounds were designed and synthesized by incorporating diversified amino acid derivatives with various lengths to the 3-amido motif of the isoxazole scaffol...

Four chlorinated N-acylalanine methylesters (metalaxyl® derivatives) containing either stereogenic centres alone as in 1 and 3 or stereogenic centres plus chiral axes as in 2 and 4 were investigated. The latter have been examined in terms of the absolute configurations of the diastereomers in un...

Novel 1,8-naphthalimides core substituted at 3-C position via imine bond with carbazole, benzothiazole, methylindole, quinoline, benzoindole, phenylmorpholine and triphenylamine derivatives were designed, synthesized and investigated with regard to their thermal, electrochemical, and luminescenc...

A series of 2β-[3′-(substituted benzyl)isoxazol-5-yl]- and 2β-[3′-methyl-4′-(substituted phenyl)isoxazol-5-yl]-3β-(substituted phenyl)tropanes were prepared and evaluated for affinities at dopamine, serotonin, and norepinephrine transporters using competitive radioligand binding assays. Th...

The conversion of isothiazoles into pyrazoles on treatment with hydrazine is investigated. The influence of various C-3, C-4 and C-5 isothiazole substituents and some limitations of this ring transformation are examined. When the isothiazole C-3 substituent is a good nucleofuge, 3-aminopyrazoles...

The interaction of 1-(3-cyano-5-nitropyridyl-2)pyridinium salts with different nucleophilic reagents yields 2-substituted 3-cyano-5-nitropyridine, including 2-polyenamino derivatives, 3-Nitro-5(H)-5-iminodipyrido/vb1,2-a:3,2-e/vbpyrimidine hydrochloride is synthesized by the reaction of 2-chloro...

In this report, a fluorescence sensor for sensitive detection of hemoglobin was developed. Gold nanoclusters were first synthesized with bovine serum albumin. It was found that both hydrogen peroxide and hemoglobin could weakly quench the fluorescence from the gold nanoclusters, but when these t...