We report the structural properties and electronic structure of a neutral homoleptic copper(II) complex bearing the anion of 1-(2-pyridylazo)-2-phenanthrol (papl). In the solid state the complex is disordered and this presents itself as a nearly equal mixture of five and six coordinate copper io...

The synthesis and study of redox-active ligand complexes has received much recent attention. We have recently explored the coordination chemistry of arylazo redox-active ligand 1-(2-pyridylazo)-2-phenanthrol (papl) and herein expand the series of complexes to the Group 8 transition metal ion, ir...

The reaction of 1-(2-pyridylazo)-2-acenaphthequinol (PAAL) with cobalt acetate in CHCl3 gave the complex of Co(PAAL-H)2 (1), and (PAAL + H)2[CoCl4]·2H2O (2) was isolated in the same system with ultraviolet light irradiation. Structures of both compounds were determined by X-Ray diffraction. The...

1-(2-Pyridylazo)-2-napthol (hereafter 1Q) is widely used as a chelating ligand applied in chelatometric, spectrophotometric analysis of metal ions. It appeared from the literature survey that no inclusion complex of 1Q was reported with nitroaromatics. The formation of charge-transfer complex gi...

ZusammenfassungDie Pyrolyse des Acetats von (+) (1R:4R:6S)-Caran-trans-4-ol (I) führt bei 10 Torr und Temperaturen zwischen 386 und 604° unter Abspaltung von Essigsäure zu einem Kohlenwasserstoff-Gemisch aus (+) (1R:6S)-Δ4-Caren (III), (+) (1R:6S)-Δ3-Caren (IV) und (+) (1R:4R)-trans-Δ2,80p-...

d-(+)-Limonene can be converted into the corresponding bicyclic organoborinate intermediate, B-methoxy-4,8-dimethyl-2-borabicyclo[3.3.1]nonane, by cyclic hydroboration with borane in THF, followed by methanolysis, and distillation of the product. Alternatively, cyclic hydroboration of d-(+)-limo...

A new and efficient route to (−)-(1R,2R,4R,6S)-1,6-epoxy-4-benzyloxycyclohexan-2-ol is described starting from (−)-quinic acid. The pivotal step involves a La3+-induced reversal of the diastereoselectivity for the borohydride reduction of an intermediate cycloxan-4-one. (1R,2R,4R,6R)-6-Propyloxy...

The SN2 transition states of the methylation reaction of DNA bases with dimethyl sulfate were examined employing DFT/ M06-2X/6-31+G∗ and DFT/B3LYP-D3/6-311+G (2df, 2p) levels of theory. Solvation effects were examined using the conductor-like polarizable continuum model (CPCM). Calculation resul...

In this study, we report an electrochemical study based on nanocellulose (NC) and single-walled carbon nanohorns (SWCNH). SWCNH and NC ensure large surface area, good conductivity, high porosity and chemical stability, becoming attractive for electrodes. The materials were characterized by X-ray...

TTF derivative of substituted pyrrole was obtained by means electrochemical synthesis, the resultant colored mix was characterized by Mass spectrometry, NMR and EPR studies, its intrinsic electronic behavior was measured by a four point probe method, besides theoretical calculations were carried...

The hitherto unknown lactone 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one and six of its substituted derivatives have been prepared by active manganese dioxide promoted oxidative cyclization of the corresponding 2-(1H-pyrrol-1-yl)benzoic acids, under mild conditions, in moderate yields. The method was...

A toxicological evaluation of two structurally related flavors with modifying properties, 3-((4-amino-2,2-dioxido-1H- benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propylpropanamide (S6973; CAS 1093200-92-0) and (S)-1-(3-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)methyl)pi...

Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor, a non-opioid branch of the opioid receptor family, shows structural similarities to traditional opioid receptors but binds opioid with very poor affinity. This receptor has been implicated in many physiological functions including pain regul...

We synthesized novel 18F-labeled acetylcholinesterase (AChE) inhibitors, 3-[1-(3- and 4-[18F]fluoromethylbenzyl)piperidin-4-yl]-1-(1-methyl-1H-indol-3-yl)propan-1-ones ([18F]1 and [18F]2) and 3-[1-(4-[18F]fluorobenzyl)piperidin-4-yl]-1-(1-methyl-1H-indol-3-yl)propan-1-one ([18F]3) in high yields...

A series of novel benzamide derivatives, altering the 4-fluorophenylalkyl moiety in cisapride, were synthesized as 5-HT4 receptor agonists, and SAR of these analogs was examined on in vitro and in vivo prokinetic activities. These compounds were synthesized for high 5-HT4 receptor binding affini...

A novel 3-((2-chlorophenyl)(piperidin-1-yl)methyl)-4-hydroxy-1-phenylquinolin-2(1H)-one was synthesized using Michael addition of secondary amine to the α, β-unsaturated carbonyl compound which was formed during the reaction. The crystal structure was studied by X-ray crystallography. Molecula...

The synthesis of fluorous (highly fluorinated) 3,4-dihydro-2(1H)-pyridone-5-carboxylate cationic amphiphiles have been described, where the dihydropyridone serves as a spacer and either a pyridinium bromide or a triphenylphosphonium bromide form the polar cationic head group. The in water self-a...

A series of racemic 4-aryl-5-(tert-butoxycarbonyl)-6-methyl-3,4-dihydro-2(1H)-pyridones have been prepared by means of a modified Hantzsch reaction using commercially available starting materials. An easy removal of the tert-butyl group of these pyridones and subsequent reaction with cesium carb...

A series of variously substituted 5-carboxy-6-methyl-3,4-dihydro-2(1H)-pyridone derivatives were synthesized and their oxidation potentials determined by cyclic voltammetry. The resulting 2-pyridone structure and a tricyclic heterocycle which was formed during an attempted synthesis of 4-(2-hydr...

To detect furaltadone metabolite 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ) in fish sample, a Eu3+ labeling time-resolved fluoroimmunoassay (TRFIA) was developed. The experimental conditions were optimized as follows: the AMOZA-OVA concentration was 0.25 μg mL−1; the antibody was diluted...