A novel 4-(morpholinomethyl)-5-oxo-1-phenylpyrrolidine-3-carboxylic acid has been synthesized and its structural elucidation has been done by UV, FT-IR, 1H and 13C NMR spectroscopy. All quantum chemical calculations were carried out at level of density functional theory (DFT) with B3LYP function...

The one-pot Mannich reaction was used to synthesize 2-(n-morpholinomethyl)-1-phenol (1a), 4-methyl-2-(n-morpholinomethyl)-1-phenol (1b), 4-chloro-2-(n-morpholinomethyl)-1-phenol (1c), 4-nitro-2-(n-morpholinomethyl)-1-phenol (1d), and 1-(n-morpholinomethyl)-naphthol (1e). The dimethylgallium comp...

N-(Morpholinomethyl) succinimide (SMF) bearing the empirical formula C9H14N2O3, has been synthesized by using the mannich condensation reaction. On considering its extensive pharmaceutical usage and medicinal value, we investigated its chemical structure and composition by employing various spec...

Isatin methyl derivatives have several pharmacotherapeutic applications, such as antibacterial, antifungal, antiviral, anticonvulsants and anticancer activities. The electrochemical behaviours of thirteen isatin-substituted derivatives with different functional groups, such as isatin 1-morpholin...

Chromoproteins are a good source of engineered biological tools. We previously reported the development of a blue fluorescent protein, termed shBFP, which was derived from a purple chromoprotein shCP found in the sea anemone Stichodacyla haddoni. shBFP contains a Leu63-Leu64-Gly65 tri-peptide ch...

17β-Amino steroids such as 17β-amino-1,3,5(10)-estratrien-3-ol (1), 17β-amino-5α-androstan-3β-ol (2) and, 17β-amino-3β-hydroxyandrost-5-ene (3) have been widely used as a key intermediates in the synthesis of a variety of biologically active steroid derivatives though concise, high yieldi...

The detergents which contain a hydrocarbon side chain longer than 16 cabron atoms were used as a perturbant for the study of protein structure. A low concentration of cetyldimethylbenzylammonium chloride (CDBA) caused difference spectra for Ac-Trp-OEt and Ac-Tyr-OEt. The Δε values at their dif...

Tryptic activity was competitively inhibited by cationic detergents which contain a cetyl group or longer hydrocarbon chains. Since the cetyl group is much longer than the side chains of lysine or arginine residues of substrates for trypsin, the nature of inhibition by cetyldimethylbenzylammoniu...

The adsorption of the cationic surfactant cetyldimethylbenzylammonium chloride (CDBACl) on octane-in-water emulsion droplets is estimated and the adsorption isotherms are determined. The adsorbed amount of CDBACl is also measured in the presence of the nonionic surfactant Tween 80, at concentrat...

The adsorption of cetyltrimethylammonium bromide (CTAB) and cetyldimethylbenzylammonium chloride (CDBACl) on a hanging mercury electrode is studied using adsorptive transfer stripping voltammetry. The surfactants are adsorbed on mercury and are then transferred in KBr or KCl under various condit...

The adsorption of binary mixtures of cetyltrimethylammonium bromide (CTAB) and cetyldimethylbenzylammonium chloride (CDBACl) at the mercury/electrolyte interface was studied in various electrolyte systems. The optimum surfactant concentration and electrolyte ratio was searched for, to obtain the...

The adsorption of cetyldimethylbenzylammonium chloride (CDBACl) on the hanging mercury electrode is studied in various supporting electrolytes at various temperatures from 1 to 50 °C. A condensed film with low capacitance is formed at negative potentials at transition temperatures below approxi...

Adsorbed cetyldimethylbenzylammonium chloride (CDBACl) or cetyltrimethylammonium bromide (CTAB) on mercury is used as template for the adsorption of CTAB, CDBACl, or their equimolar mixture at 20 °C. Adsorptive stripping voltammetry with the two step procedure is used. The results are compared ...

The effect of deaeration on the adsorption of a mixture of cetyltrimethylammonium bromide and cetyldimethylbenzylammonium chloride at the mercury/electrolyte interface solution is studied using capacitance measurements focusing mainly at very low temperatures. Isochronous capacitance vs potentia...

Butyric acid-producing strain Clostridium tyrobutyricum ATCC25755 produces acetic acid as a byproduct, which lowers butyric acid yield and selectivity. Supplementing glycerol would be a rational approach to enhance a NADH-requiring metabolite butyric acid selectivity by increasing NADH availabil...

Fe3+ and Al3+ ions existed in phosphoric acid–nitric acid solutions are very troublesome for the neutralization process of nitrophosphate (NP) fertilizer. This paper studied the performances of three chelating resins (S957, S950 and S930) on the removal of Fe3+ and Al3+ ions from phosphoric aci...

Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis ...

Both [1-14C]glucose and 2-[1-14C]deoxyglucose (2-DG) revealed selective autoradiographic labelling to tones in the inferior colliculus of the cat with short stimulation periods (5–15 min). With longer periods of stimulation (45 min), the selectivity disappeared with glucose but remained with 2-...

SummaryThe AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal muscle. We evaluated two distinct direct activators of AMPK: a non-selective activator of all AMPK complexes, PF-739, and an activator s...

Previously, we reported that oral stimulation with Gymnema sylvestre (GS), a plant that selectively suppresses sweet taste sensation in humans, delayed gastric emptying and glycemic response during and after oral glucose ingestion. It is unclear whether these responses are triggered by sweet tas...