Rat models based on viral vector-mediated overexpression of α-synuclein are regarded as highly valuable models that closely mimic cardinal features of human Parkinson's disease (PD) such as L-DOPA-dependent motor impairment, dopaminergic neurodegeneration and α-synuclein inclusions. To da...

BackgroundLow Molecular Weight Phosphotyrosine Protein Phosphatase (LMW-PTP) is an enzyme involved not only in tumor onset and progression but also in type 2 diabetes. A recent review shows that LMW-PTP acts on several RTK (receptor tyrosine kinase) such as PDGFR, EGFR, EphA2, Insulin receptor. ...

Background and purposeTGR5 plays an important role in many physiological processes. However, the functions of TGR5 in the regulation of the glucose metabolism and insulin sensitivity in the skeletal muscles have not been fully elucidated. We synthesized MN6 as a potent and selective TGR5 agonist...

Dicesium bis(1,2-dithiole-3,5-dithiolato-4-yl)disulfide, 3, was obtained by aerial oxidation of dicesium 1,3-dithiole-3-thione-4,5-dithiolate in aqueous ethanol. The dianion in 3, in the 4e special positions of the space group Pbcn, lies on a crystallographic twofold axis and has, therefore, C2 ...

The coordination chemistry of the ammonia solvated copper(II), zinc(II) and cadmium(II) ions has been studied in liquid and aqueous ammonia by means of EXAFS spectroscopy, and in the solid state by means of crystallography and EXAFS spectroscopy. The ammonia solvated copper(II) ion is six-coordi...

The thermodynamics of the reactions of ciprofloxacin (CIP) with calcium perchlorate (Ca(ClO4)2) and magnesium perchlorate (Mg(ClO4)2) have been investigated in water–methanol solvent using conductometric titration. The reactions of CIP with each ion produce two ionic complexes with the general ...

Three new cadmium(II) complexes, [Cd(dede)(μ-1,3-N3)(μ-1,1-N3)]n (1), [{Cd3(L1)2(μ-1,1-N3)4(CH3OH)2}·2CH3OH·2H2O]n (2) and [(CdL2)3(μ-1,1,1-OH)][(CdL2)3(μ-1,1,1-N3)](ClO4)4·H2O (3) {dede = N,N-diethyl-1,2-diaminoethane, HL1 = 2-(2-((diethylamino)ethylimino)methyl)phenol and HL2 = 2-(2-((...

We report an efficient method to biosynthesize biocompatible cadmium telluride and cadmium sulphide quantum dots from the fungus Rhizopus stolonifer. The suspension of the quantum dots exhibited purple and greenish-blue luminescence respectively upon UV light illumination. Photoluminescence spec...

Four new octahedral cadmium(II) complexes, [(Cd)(L1)(HL1)](ClO4) (1), [Cd2(L2)2(SCN)2(CH3OH)2] (2), [(CdL3)3(μ-1,1,1-OH)](ClO4)2 (3) and [Cd2(L4)2(SCN)(NO3)] (4) have been synthesized using four Schiff bases, HL1, HL2, HL3 and HL4, (where HL1 = 2-(2-(ethylamino)ethyliminomethyl)phenol, HL2 = 2-...

Two new dinuclear cadmium(II) complexes, [Cd(L1)2Cd(SeCN-κ-Se)2] (1) and [Cd(L2)2Cd(SeCN-κ-Se)2] (2), where HL1 = {2-(3-(dimethylamino)propyliminomethyl)-6-methoxyphenol} and HL2 = {2-(3-(dimethylamino)propyliminomethyl)-6-ethoxyphenol}, have been prepared and characterized by elemental and sp...

A dinuclear centrosymmetric cadmium(II) Schiff base complex, [Cd2(L)2(μ-1,3-SCN)2(CH3OH)2], {HL = 2-(3-(methylamino)propyliminomethyl)-4,6-dichlorophenol} has been synthesized and characterized. X-ray crystallography has confirmed its structure. The complex crystallizes in monoclinic space grou...

Condensation of N,N-dimethyl-1,3-diaminpropane with salicylaldehyde, 3-methoxysalicylaldehyde and 3-ethoxysalicylaldehyde produces three Schiff bases, HL1 [2-(3-(dimethylamino)propylimino)methyl)methoxyphenol], HL2 [2-(3-(dimethylamino)propylimino)methyl)-6-methoxyphenol], and HL3 [2-(3-(dimethy...

Room temperature X-band electron spin resonance (ESR) spectra of manganese (II) doped single crystals of barium chloride dihydrate have been studied. Manganese(II) dopings ranging from 0.03 to 28.5 mol % were examined. The calculated line broadening as a function of manganese(II) concentration i...

Diglycine Barium Chloride Monohydrate have been synthesized and characterized by the 13C and 1H NMR spectroscopy and single crystal X-ray structural studies with a detailed analysis of Hirshfeld surface and fingerprint plots facilitating the interactions within the crystal structure. The Protona...

The sufficient presence of trace elements (TE) is essential for anaerobic digestion. Barium (Ba) is considered a non-essential trace element that can be collaterally added to digesters as part of low-cost trace element sources or because of its presence in some feedstocks, such as crude glycerol...

At present, beneficial effects of melanin and harmful effects of barium have been reported. However, little is known about the adsorption of barium, and even less is known about the biological significance of adsorption of barium by melanin. In this study, we showed that there was a strong corre...

In this manuscript we investigate the impact of oxalate ions on the crystallization of barium sulfate. The organic anion, oxalate, was found to inhibit both nucleation and growth according to atomic force microscopy measurements and dynamic light scattering data. Raman confocal imaging was used ...

Barium Chloride dihydrate (BaCl2 · 2H2O) was given for 92 days to B6C3F1 mice and Fischer 344N rats in their drinking water at levels of 0, 125, 500, 1000, 2000, and 4000 ppm. The no-effect level for this study was 2000 ppm BaCl2 · 2H2O in the drinking water. At 4000 ppm, daily consumption for...

The objectives of the present work were: (1) to assemble population-level biomonitoring data to identify the concentrations of urinary and plasma barium across the general population; and (2) to derive biomonitoring equivalents (BEs) for barium in urine and plasma in order to facilitate the inte...

The formation of scales in the petroleum industry, such as those composed of calcium and barium sulfates, may reduce productivity since these sediments can partially or totally obstruct the pipes. The mitigation of these inorganic precipitates can be accomplished by using scale inhibitors or by ...