ObjectiveThe purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.

A DMEDA-promoted and copper-catalyzed approach has been designed for the coupling of aryl halides and chiral α-aminoamides to afford a range of functionalized chiral α-amino anilides. This method has a higher yield and better reproducibility than those under ligand-free conditions. Of the two ...

Kinetic resolution of rac-1,2-diols using the biocatalyst Burkholderia cepacia lipase (BCL) immobilized on a biodegradable binary blend support of hydroxypropyl methyl cellulose(HPMC)/polyvinyl alcohol (PVA) has been investigated. The immobilization technique improved enzyme activity significant...

Some new thieno[2,3-d]pyrimidin-4(3H)-ones containing 1,2,4-triazole and 1,3,4-thiadiazole moiety were synthesized using thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazides as precursors in order to determine their cytotoxicity. Compounds 5, 7–8 and 10–18 were evaluated for their cytotoxical effec...

In the present study, a series of 7-[4-(5-amino-1,3,4 thiadiazole-2-sulfonyl)]-1-piperazinyl fluoroquinolonic derivatives VIIa–d were synthesized in good yields and characterized by IR, 1H-NMR, 13C-NMR, FAB Mass spectral and elemental analyses. The compounds were evaluated for their preliminary...

A number of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were synthesized and evaluated for their antiproliferative activities. The panel substitution included alkyl, aryl, and morpholinoalkyl derivatives. The structures of compounds were identified from elemental, IR, 1H NMR...

Novel polydentate Schiff bases 4-(5-mercapto-1,3,4-thiadiazol-2-ylimino)pentan-2-one (S1) and (2-(indol-3-yl)vinyl)-1,3,4-thiadiazole-2-thiol (S2) were synthesized and explored as Cu2 + selective polymeric membrane electrodes (PME) using different plasticizers and anionic excluders. The potentio...

New compounds 5-benzyl-N-phenyl-1,3,4-thiadiazol-2-amine (Bptha, 1), 2-(5-phenyl-1,3,4-thiadiazol-2-yl) pyridine (Pthp, 2) and 2-(5-methyl-1,3,4-thiadiazole-2-ylthio)-5-methyl-1,3,4-thiadiazole (Mtmth, 3) have been synthesized and characterized with the aid of elemental analyses, IR, NMR and sin...

Density functional theory (DFT) with two functionals, namely B3LYP and CAM-B3LYP with the 6-311 ++G(d,p) basis set was performed on six 2-amino-5-alkyl-1,3,4-thiadiazole derivatives (IC-2 to IC-13) used as corrosion inhibitors for steel in 1.0 M H2SO4 solution, along with the calculations on the...

The title reagent (TDH2) has been used to precipitate cadmium from aqueous solution. The rate of extraction is rapid (12ca. 2 min). A Scatchard plot has two clear regions which have values K1 = 7.2 × 106 (n̄1 0.038) and K1 3.2 × 106 (n̄2 0.29). The first region is probably associated with (Cd ...

The synthesis of some new transition metal complexes with 1,3,4-thiadiazole-2,5-dithiol derivatives (L1 and L2) as new ligands is reported. Each complex was prepared by the reaction of the ligands with the appropriate metal salts (CrCl3, MnCl2·4H2O, FeCl3, CoCl2·6H2O, NiCl2·6H2O, CuCl2·2H2O,...

1,3,4-thiadiazole-2,5-dithiol (TDH2) has been used to precipitate cadmium from aqueous solution. The rate of extraction is rapid (t1/2 ca. 2 min.). A Scatchard plot has 2 clear regions which have values K1 7.2 × 106 (n1 38 mM M−1) and K2 3.2 × 106 M (n2 290 mM M−1). The first region is probabl...

The precursors MH2(CO)(PPh3)3 (M = Ru or Os), Ru(CO)3(PPh3)2/OsH2(CO)2(PPh3)2 and IrH(CO)(PPh3)3 react with 1,3,4-thiadiazole-2,5-dithiol (tddtH2) in boilig toluene to afford the 1,3,4-thiadiazole-2,5-dithiolato (tddtH) complexes M(tddtH)2(CO)(PPh3)2, M(tddtH)2(CO)2(PPh3)2 and IrH(tddtH)2(CO)(PP...

In this research, a novel adsorbent gold nanoparticle loaded on activated carbon (Au-NP-AC) was synthesized by ultrasound energy as a low cost routing protocol. Subsequently, this novel material characterization and identification followed by different techniques such as scanning electron micros...

Salt formation approach was taken to improve Mebendazole (MBZ) solubility. MBZ polymorph A was easily recrystallized as a 1:1 nitrate salt (MBZ N) in methanol. Single crystal X-ray diffraction data show that MBZ N crystallizes in the P1¯ space group. By strong intermolecular H-bonding interacti...

In this work, the thermal decomposition of mebendazole (MBZ) was studied to elucidate divergent data found in the literature concerning the thermal behavior of this drug. To this end, thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), evolved ga...

A series of novel and readily accessible N-benzylated (N-arylcarbamoyl)alkylphosphonate esters and related compounds have been prepared as potential antimalarial agents. Bioassays reveal that some of these compounds exhibit promising activity against Plasmodium falciparum, and exhibit no signifi...

Structure–activity relationships for the A-region in a series of N-4-t-butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamides as TRPV1 antagonists have been investigated. Among them, the 3-fluoro analogue 54 showed high binding affinity and potent antagonism for both rTRPV1 and hTRPV1 in CHO ...

The chloro(ligand-C,N)triphenylphosphinepalladium(II) complexes with cyclopalladated N,N-dialkylbenzylamines (alkyl = methyl, ethyl and n-propyl), azobenzene, 8-methylquinoline, dimethylaminomethylferrocene and 2-benzylpyridine undergo lithium chloride-induced solvolysis in acetic acid solvent u...

Metal-organic Frameworks (MOFs) as a new type of nanomaterials are extensively used in various fields of environment pollution remediation. However, the MOFs are rarely applied in the removal of cyanobacterial blooms, and more fundamental investigation is warrant for more insights into mechanism...