ContextBusiness processes are an important asset of every organisation and can be divided into a group of structured processes (i.e. procedural) and loosely structured ones (i.e. declarative). A good example of procedural notations is Business Process Model and Notation (BPMN), a technologically...

We studied the flazasulfuron behavior in a soil amended with three organic wastes (municipal solid waste, MSW, poultry manure, PM, and cow manure, CM) and their influence both on its mobility and on the soil’s biochemical properties (soil humus-enzymatic complexes, soil microbial biomass-C and ...

Biosynthesis of melanin byColletotrichum lagenariumis essential for appressorial penetration of its host plants. Carpropamid is a novel melanin-inhibiting fungicide for control of rice blast caused byMagnaporthe grisea.InC. lagenarium,appressorial and colonial melanization were inhibited by carp...

The metabolism of sorbinil ((+)6-fluoro-spiro (chroman-4, 4′-imidazolidine)-2′,5′ dione), an aldose reductase inhibitor associated with immunological adverse reactions, was studied in vivo and in vitro with particular reference to the formation of protein conjugates of 2-hydroxysorbinil and t...

The determination of urinary 3-phenoxybenzoic acid enables exposure to pyrethroid insecticides to be evaluated. A method for the quantitative determination of this metabolite in urine is described. The compound and the internal standard (2-phenoxybenzoic acid) are derivatized with pentafluoroben...

Cilazapril, a moisture-sensitive compound, is known to undergo rapid degradation which could be additionally facilitated by the presence of excipients that contain or absorb moisture. Hence we investigated the stability of cilazapril in two commercially-available dosage forms and in binary mixtu...

The development of stability-indicating method with isocratic elution mode based on micellar liquid chromatography for the analysis of cilazapril, hydrochlorothiazide and their degradation products was the primary aim of the present research. Since this could be done using different methodologie...

BackgroundO-linked β-N-acetylglucosamine (O-GlcNAc) is a nutrient-/stress-sensitive post-translational modification that affects nucleocytoplasmic proteins. The enzyme O-N-acetylglucosamine transferase (OGT) catalyzes the addition of O-GlcNAc, whereas O-N-acetylglucosaminidase (OGA) removes it....

Tussilagone is a sesquiterpenoid which exhibits a variety of pharmacological activities. The interaction of tussilagone with human serum albumin (HSA) was investigated using fluorescence spectroscopy, UV–vis absorption, fluorescence probe experiments, synchronous fluorescence, circular dichrois...

Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments are associated with poor tolerability and insufficient therapeutic efficacy, prompting the need for alternative therapeutic approaches. Recent advances suggest ...

The occurrence of cephalosporin antibiotics in water resources has caused increasing concerns about their potential effects on ecosystem and human health. However, reports on the efficient removal of these antibiotics are limited. In this work, a superior hydroxyl-functionalized ionic liquid bas...

Porous NiTiO3 nanorods were synthesized through the sonochemical route followed by calcination at various temperature conditions. Surface morphology of the samples was tuned by varying the heat treatment temperature from 100 to 600 °C. The synthesized NiTiO3 nanorods were characterized by trans...

We report the synthesis of 5′-modified thymidines (16, 18, 21, 23) and 5,5′-bis-substituted 2′-deoxyuridine analogues (30, 47) as inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt). These analogues were evaluated for their capacity to inhibit TMPKmt and solely...

Nonlinear optical (NLO) activity of the compound (2E)-2-(ethoxycarbonyl)-3-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)amino] prop-2-enoic acid is investigated experimentally and theoretically using X-ray crystallography and quantum chemical calculations. The NLO activity is confirmed by both powder S...

The syntheses of N-desmethyl derivatives of CDB-2914 and the mono-N-desmethyl derivative of Mifepristone are described. We also describe the use of the mono-desmethyl derivatives as substrates for the synthesis of N-tritomethyl derivatives of CDB-2914 and Mifepristone with high specific activity...

Triple-negative breast cancer (TNBC) is one of the most malignant breast cancers currently with a lack of targeted therapeutic drugs. Accumulating evidence supports that KLF5 represents a novel therapeutic target for the treatment of basal TNBC. Our previous studies revealed that mifepristone is...

A series of ethylene oligomerization catalysts based on bidentate phenoxy-imine ligands coordinated to nickel is reported. The phenoxy-imine nickel(II) complexes of the general structure, [(2,6-R2C6H3N = C-3-R′C6H3O)2Ni] (R′ = H, 1; tBu = 2; R = Me, a; Et, b; iPr, c), modifying their structura...

Nickel(II)carboxylate salts or nickel(II) chloride react with excess ethylaluminum sesquichloride or ethylaluminum dichloride in benzene to produce a diamagnetic orange-brown complex. The amount of this complex increases with an increase of the ethylaluminum dichloride content of the ethylalumin...

Reactions of diethylaluminum chloride, ethylaluminum dichloride and ethylaluminum sesquichloride with sodium sulfate were carried out. Diethylaluminum chloride exchanges quantitatively chlorine for sulfate with sodium sulfate,and forms a n-heptane-soluble organometallic compound having the empir...

A series of cobalt(II) (1a–6a) and nickel(II) (1b–6b) complexes supported by imino- or amino-pyridyl alcohol ligands (tridentate [NNO]), 2-(2,6-R12C6H3N=CMe)-6-{(HO)CR2}C5H3N (L1–L4) and 2-(2,6-R12C6H3NHCHMe)-6-(CH2OH)C5H3N (L5 and L6), were synthesized and characterized by elemental and spec...