A magnetic CoFe2O4 nanoparticle immobilized diamine-N-sulfamic acid (CoFe2O4@SiO2–DASA) was synthesized and used as efficient heterogeneous catalyst for the synthesis of amides via the Ritter reaction under solvent-free conditions. The magnetic nanocatalyst could be readily recovered by applyin...

The dysfunction and mutual compensatory activation of RAF-MEK-ERK and PI3K-PDK1-AKT pathways have been demonstrated as the hallmarks in several primary and recurrent cancers. The strategy of concurrent blocking of these two pathways shows clinical merits on effective cancer therapy, such as comb...

Transition metal coordination complexes of Co(II), Ni(II), Cu(II) and Zn(II) with a newly designed ligand, 2-(2-(1H-benzo[d]imidazol-2-yl)hydrazono)propan-1-ol have been synthesized and characterized using various spectro-analytical techniques. The molecular structures of Co(II), Cu(II) and Zn(I...

Need for new drugs to fight against tuberculosis (TB) is increasing day by day. In the present work we have taken a spiro compound (GSK 2200150A) reported by GSK as a lead and we modified the structure of the lead to study the antitubercular activity. For structure activity profiling twenty-one ...

The proposal that 4-methylumbelliferone esters are substrates for pancreatic lipase was evaluated. Purified pancreatic lipase was found to give only 0.2% the activity with 4-methylumbelliferone caprylate (4-MUCA) as compared to triolein when the usual titrimetric method of assaying lipase was em...

The amide bond between an amino acid and proline can take the trans- or cis-conformation. The conformation influences both the structure and function of peptides and proteins. Therefore, constrained mimetic, which corresponds to Pro-dipeptides whose amide bond is replaced with an (E)- or (Z)-alk...

The PMR spectra (60 MHz) of several aryl and substituted-methyl thiourea derivatives are reported. In the para-substituted aryl derivatives, the observed aromatic proton chemical shifts agree well with calculated values using −0.03 ppm for both the ortho- and meta-substituent constants of the —...

We present a comparative study on the optical storage characteristics of mixed Langmuir–Blodgett (LB) films from azobenzene polymers and cadmium stearate. The amplitude of induced birefringence depends on the azobenzene content in the polymer as well as on the rate of trans–cis–trans isomeriz...

The extent of ionic association of (hept)4NCl, (hept)4NBr, (hept)4NI, (hept)4N(NO3) and (oct)4P(NO3) in methyl isobutyl ketone at 55°C has been measured by vapour pressure osmometry with matched thermistors. From the dependence of the osmotic coefficient on the solute concentration the equilibr...

Transport of hydrophobic tetraalkylammonium chlorides (tetrabutylammonium, tetrapentylammonium, tetrahexylammonium and tetraheptylammonium) across a porous polytetrafluoroethylene resin film impregnated by 1-octanol between two aqueous phases is interpreted by considering the steady-state flows ...

Phosphorylation of amino acid residues in proteins plays a major role in biological systems. In this paper, a reversed-phase high performance liquid chromatographic (HPLC) method based on chemical derivatization has been described for the separation and quantification of phosphoamino acids at fe...

Conventional C18 silica columns have proven to be useful for the analysis of amino acids (AA) from protein hydrolysates but undesirable peak overlapping is usually found when analyzing body fluids given that a large number of AAs are present in the samples. As an alternative to silica packings, ...

A new succinimidyl ester amine-reactive reagent, N-hydroxysuccinimidyl phenylacetate (SIPA), has been synthesized for analytical derivatization of aliphatic amines, such as methylamine, ethylamine, propylamine, butylamine and pentylamine in gas chromatography (GC). The derivatiation conditions w...

In-house method validation was conducted to determine amino acid composition in gelatin by a pre-column derivatization procedure with the 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate reagent. The analytical parameters revealed that the validated method was capable of selectively performing a ...

Robust, efficient identification and accurate quantification of N-glycans are of great significance in N-glycomics analysis. Here, a simple and rapid derivatization method, based on the combination of microwave-assisted deglycosylation and 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) la...

We report the spatially controlled, protecting group free, catalytic assembly of a library of nineteen 7-component cascade products generated from a novel planar trisallenyl 1,3,5-triazinane-2,4,6-trione core in combination with aryl iodides and amines with excellent regio and good stereoaselect...

A new-type exciplex emission was obtained employing hole-transporting material 4,4,4″-tris[3-methylphenyl(phenyl)amino]triphenylamine (m-MTDATA) doped in the electron-transporting material 2,2,2″-(1,3,5-benzenetriyl)tris-[1-phenyl-1H-benzimidazole] (TPBI) with structures of ITO/m-MTDATA (45 nm...

An investigation into the oxidative electrochemistry of 1,3,5-Tris[4-[(3-methylphenyl)phenylamino]phenyl]benzene (TMPB) is described. In particular, the heterogeneous electron-transfer kinetics in N,N-dimethylformamide (DMF) and dichloromethane (DCM) are studied using the high-speed microband ch...

The aim of the study was to develop an efficient sorbent for the separation of dopamine. 4-(2-Aminoethyl)aniline was chosen as a pseudo-template to produce the imprinted polymers from seven different functional monomers in the presence of ethylene glycol dimethacrylate as a cross-linker. The bin...

Racemic (1SR,2SR,4SR,5SR)-2-[(4′-hydroxy-3′-methoxy)-phenoxy]-4-(4″-hydroxy-3″-methoxy-phenyl)-8-hydroxy-6-oxo-3-oxabicyclo[3.3.0]-7-octene (2, C21H20O8) was isolated as major product of soybean lipoxygenase action on curcumin (1, C21H20O6). The structure of 2 was elucidated by HPLC-APCI-MS ...