A novel solid–solid phase change materials, namely, cellulose acrylate-g-poly (n-alkyl acrylate) (CA-g-PAn) (n = 14, 16 and 18) were successfully synthesized by free radical polymerization in N, N-dimethylacetamide (DMAc). The successful grafting was confirmed by fourier transform infrared spec...

A novel shape-stabilized solid-solid phase change material of graphene oxide-grafted-poly(hexadecyl acrylate) (GO-g-PHDA) was fabricated by hexadecyl acrylate (HDA) covalently bonding to GO nanosheets via in free radical polymerization (FRP). The evidences of various spectroscopic and microscopi...

Temperature and electric field-responsive liposomes were prepared by decorating the liposomal surface with poly(hydroxyethyl acrylate-co-hexadecyl acrylate-co-carboxyethyl acrylate) (P(HEA-HDA-CEA)). Only the liposome incorporating the copolymer having lower critical solution temperature release...

Evidence is presented indicating that the bean pathogen Fusarium solani f. sp. phaseoli is able to metabolize the phytoalexin phaseollin in vitro. Phaseollin is metabolized in shake cultures of actively growing mycelium exposed to a concentration non-inhibitory to growth. An inhibitory concentra...

Metabolism of the bean phytoalexin, phaseollin, to 1a-hydroxyphaseollone by Fusarium solani f. sp. phaseoli appears to occur by way of an inducible mono-oxygenase. Evidence for this conclusion is that: (1) pretreatment with selected aromatic compounds, as well as phaseollin itself, enhanced the ...

Plant cells, from bean and tobacco suspension cultures and from pods and hypocotyls of bean, were rapidly killed following immersion in solutions containing 30 μg phaseollin per ml. These concentrations inhibited the respiration of bean cells within 2 min of treatment and also reduced the growt...

Phaseollin, but not pisatin or medicarpin, at 10−4M caused loss of electrolytes and betacyanin from beet root storage tissue and killed beet leaf protoplasts. Increasing the concentration of sucrose in the incubation medium caused a decrease in the rate of efflux of electrolytes by phaseollin tr...

Phaseollin is metabolised by cultures of Septoria nodorum, a non-pathogen of bean, into cis and trans isomers of 12,13-dihydrodihydroxyphaseollin. These products are much less fungitoxic than phaseollin which suggests that the capacity to detoxify phytoalexins is not confined to pathogenic fungi.

Following fungal-inoculation, P. vulgaris was found to produce small amounts of 7,4′-dihydroxyisoflavone (daidzein), 7,2′,4′-trihydroxyisoflavone, 7,2′,4′-trihydroxyisoflavanone, (6aR, 11aR)-3,9-dihydroxypterocarpan, and (3R)-7,2′,4′-trihydroxyisoflavan. The structures of the latter four ...

The genus Erythrina (Leguminosae), consisting of over 100 different species, is distributed in tropical regions. In traditional medicine, Erythrina species are used to treat cancer, but little is known about the anticancer mechanisms. From the stem bark of Erythrina addisoniae Hutch. & Dalziel, ...

Two metabolites of the phytoalexin phaseollin (1) produced by cultures of the fungus Colletotrichum lindemuthianum have been assigned structures (3) and (4).

Feeding experiments in CuCl2-treated French bean (Phaseolus vulgaris) seedlings have demonstrated that labelled 2′,4′,4-trihydroxychalcone, daidzein, 7,2′,4′-trihydroxyisoflavone, 3,9-dihydroxypterocarpan and phaseollidin are all good precursors of the pterocarpan phytoalexin phaseollin. The...

Acting in a manner similar to that of glyceollins I and III, phaseollin appears to inhibit proton transport in red beet tonoplast vesicles. In the presence of 80 μM phaseollin, proton transport in tonoplast vesicles was inhibited by >90%. This inhibition appears to be due to increased conductan...

A series of eight compounds diethyl-3-methyl-5-(6-methyl-2-thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamido) thiophene-2,4-dicarboxilate (KM10–17) analogues have been prepared by conventional methods and characterized by IR, Mass, NMR and elemental analysis. In silico docking studies ...

A novel series of 3-hydroxyquinazoline-2,4(1H,3H)-diones derivatives has been designed and synthesized. Their biochemical characterization revealed that most of the compounds were effective inhibitors of HIV-1 RNase H activity at sub to low micromolar concentrations. Among them, II-4 was the mos...

Aberrant activation of B cell receptor (BCR) signal transduction cascade contributes to the propagation and maintenance of B cell malignancies. The discovery of mall molecules with high potency and selectivity against Bruton’s tyrosine kinase (BTK), a key signaling molecule in this cascade, is ...

A lipophilic thioguanosine (5′-tert-butyl-dimethylsilyl-2′,3′-O-isopropylidene thioguanosine, TG) behaves as an anion receptor for CsF, and both deprotonation reaction and supramolecular interactions involved.

BackgroundAdenosine-5′-diphosphate (ADP) can influence intrarenal vascular tone and tubular transport, partly through activation of purine P2Y12 receptors (P2Y12-R), but their actual in vivo role in regulation of renal circulation and excretion remains unclear.

The adiabatic laminar burning velocities of a commercial gasoline and of a model fuel (n-heptane, iso-octane, and toluene mixture) of close research octane number have been measured at 358 K. Non-stretched flames were stabilized on a perforated plate burner at 1 atm. The heat flux method was use...

The IET spectra of 1,2-benzenedimethanol and 2-hydroxyphenethyl alcohol adsorbed on thin-film aluminium and magnesium oxide suggest that seven-membered chelate ring formation is probable at both oxide surfaces. In like manner, 2-hydroxybenzyl alcohol adsorption may involve six-membered chelate r...