Organophosphonates are a group of chemical agents which have high bioactivity. In the present study, we aimed to investigate the anticancer activity of the synthesized β-lactam derivatives of α-amino phosphonates on solid tumor and human leukemic cell lines. The results show that one of these ...

A new platinum(II) complex of [PtII(L) (pn)]Cl·2H2O (1) (pn = 1,3-propanediamine) with 2-(4-methoxy-phenyl)imidazo [4,5-f]-[1,10]phenanthrolin (H-L) was synthesized and characterized. In complex 1, the platinum adopts a four-coordinated square planar geometry. Complex 1 exhibited selective cyto...

The distribution of tin(IV) between aqueous hydrochloric acid solutions and solutions of di(2-ethylhexyl) phosphoric acid (DEHPA, HX) in kerosene has been investigated under different conditions. Spectrophotometry, infrared and nuclear magnetic resonance spectral measurements were made of the or...

Proton exchange membrane water electrolysers operating at typically 80 °C or at further elevated temperatures suffer from insufficient catalyst activity and durability. In this work, antimony doped tin oxide nanoparticles were synthesized and further doped with an inorganic proton conducting ph...

This work presents the development of a new hybrid material composed of metal-organic-framework, MIL-101 (Cr) and mesoporous tin phosphate nanoparticles. The phosphate groups of the composite impart Brønsted acidity, while the Cr and Sn atoms act as the Lewis acid sites, thus promoting it as a d...

Poly(ethylene phosphoric acid)s (PEPA)s of different compositions, namely homopolymers, and diblock and triblock copolymers containing poly(ethylene glycol) monomethyl ether, l-lactide, and ε-caprolactone blocks, can be quantitatively obtained by mild thermolysis of polymers based on tert-butyl...

Comb-shaped polysulfone anion exchange membranes (AEMs) containing various pendant alkyl side chains were synthesized and characterized. Ionic clusters aggregation is observed in transmission electron microscopy (TEM) image and small-angle X-ray scattering (SAXS). The comb-shaped quaternized amm...

Valproic acid (VPA), a branched short-chain fatty acid, is generally used as an antiepileptic drug and a mood stabilizer. VPA is a relatively safe drug, but its use in higher concentrations is associated with idiosyncratic neurotoxicity. Investigations involving cerebral cortex and cerebellum ca...

Protein thiol oxidation and modification by nitric oxide and glutathione are emerging as common mechanisms to regulate protein function and to modify protein structure. Also, thiol oxidation is a probable outcome of cellular oxidative stress and is linked to degenerative disease progression. We ...

During the developmental processes from dry seeds to seedling establishment, the glyoxylate cycle becomes active in the mobilization of stored oils in the scutellum of barley (Hordeum vulgare L.) seeds, as indicated by the activities of isocitrate lyase and malate synthase. The succinate produce...

Thiol oxidation is a probable outcome of cellular oxidative stress and is linked to degenerative disease progression. In addition, protein thiol redox reactions are increasingly identified as a mechanism to regulate protein structure and function. We assessed the effect of hypothiocyanous acid o...

Background and AimsA short branched chain fatty acid, valproic acid (VPA), has been used worldwide for decades in the intervention of seizure disorders, neuropathic pain and migraine. However, several adverse effects of VPA have been reported over the years. The aim of our investigation was to e...

Identification of pharmacologically potent antioxidant compounds for their use in preventive medicine is thrust area of current research. This study was undertaken with the aim of determining the protective role of syringic acid (SA) on isoproterenol (ISO) induced myocardial infarction (MI) in r...

A method for the determination of cyanate concentration in blood plasma over the range 1 to 1000 μm is presented. Cyanate present in the dried residue of acetone-deproteinized plasma is converted to a chromophoric thiocarbamyl derivative by addition of pH 3.0-buffered thionitrobenzoic acid. The...

Nitric oxide is an important vasodilator which can be biologically produced from leukocytes and endothelial cells. However, it is highly unstable, which is an obstacle to detection and quantitation. We have exploited the reactivity of nitric oxide with thiols to establish an assay based on oxida...

Two model peptides have been synthesized, a pentapeptide 1 (Boc-Gly-ΔZPhe-Leu-ΔZPhe-Ala-NHMe) and an octapeptide 2 (Boc-Val-ΔZPhe-Phe-Ala-ΔZPhe-Phe-Ala-Leu-Ala-gDZPhe-Leu-OMe). The conformations have been investigated in chloroform and dimethylsulfoxide by one and two dimensional NMR techniq...

Co-oligomerization of propadiene with propyne catalyzed by tetrakis(ligand)nickel(0) complexes is accompanied by homo-oligomerizations of both monomers. Six phosphorus(III) ligands with rather different electronic and steric properties were chosen and the course of the reaction was found to be l...

Treatment of α-halogenated carbonyl or cyano compounds with hexamethyldisilane in the presence of catalytic amounts of tetrakis(triphenylphosphine)-palladium gives the corresponding parent carbonyl or cyano compounds in excellent yields via oxy-π-allyl(trimethylsilyl)palladium intermediates.

We defined the smallest enclosing cone angle as the Tolman cone angle for null atomic spheres radii. Then we provide a simple analytical algorithm to compute the smallest enclosing cone at fixed apex, which works in the case of unsymmetrical ligand. We applied it to compute ligand cones for a fa...

The syntheses of reactively functionalized 2,5-siloles by the Kumada-type nickel-catalyzed intramolecular cyclization of alkynes and disilane, and their subsequent polymerization with diketopyrrolopyrrole (DPP) are described. The prefunctionalization of the 2,5-positions of the silole ring, whic...