A series of novel 5-(1-aryl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)-1H-tetrazoles 7(h-s) were designed and synthesized. Structural characterization was done by spectral and single crystal X-ray studies. The intermolecular interactions of compound 7n were quantified and visualized using Hirshfeld surf...

In continuation of our efforts to find new biologically active agents, regioselective synthesis of a series of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-arylethanones 4a–k has been achieved under facile, extremely mild and greener reaction conditions with excellent yields. Moreover, one pot multicompo...

The title compound (3) was obtained by cyclocondensation of 4-methylbenzohydrazide (2) with 3-chloropentane-2,4-dione (1) in dry ethanol in presence of acetic acid and recrystallization from ethanol. The molecular and crystal structure of the new pyrazole derivative was determined by single crys...

In recent years, inhibition of HDAC6 became a promising therapeutic strategy for the treatment of cancer and HDAC6 inhibitors were considered to be potent anti-cancer agents. In this work, celecoxib showed moderate degree of HDAC6 inhibition activity and selectivity in preliminary enzyme inhibit...

We have designed and synthesized an unsymmetrical zinc phthalocyanine (PCA-ZnPc-1) bearing an electron-withdrawing pyrazole-3-carboxylic acid anchoring group and three electron-donating tert-butyl groups as a sensitizer for dye-sensitized solar cells (DSSCs). PCA-ZnPc-1 sensitized solar cell sho...

Pyrazole carboxylic acid derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide (inhibitor 1) were synthesized from ethyl 3-(chlorocarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-4-carboxylate compound. The inhibitory effects of inhibitor 1, acetazolamide (AAZ) and of 11 newly synthesized amide...

New (η6‒p‒cymene) ruthenium(II) complexes containing Schiff base ligands of the general composition [RuCl(η6‒p‒cymene)(L1‒3)] have been synthesized. The complexes were characterized by analytical and spectral (FT‒IR, UV–Vis, 1H NMR and 13C NMR) methods. The molecular structure of the represen...

With the isothermal dissolution equilibrium method, the solid-liquid phase equilibrium for 5-amino-3-methyl-1-phenylpyrazole in ten organic solvents including methanol, ethanol, n-propanol, isopropanol, 2-butanone, acetonitrile, n-butanol, toluene, 1,4-dioxane and isobutanol was established over...

Treatment of N,N′-bis(mesityl)pyridine-2,6-carboxyimidoyl dichloride, 1, in toluene solution with [Pt(PPh3)4] at 100 °C afforded a novel platinacyclic compound, 3, in 63% yield, instead of the expected compound 2. The molecular and crystal structures of the title compound, 3, have been determi...

A series of neutral complexes of platinum(II) of general formula [PtCl2L(PPh3)] [L = Et2NC(Me)NH, SOMe2, CO, Et2NH, (HOCH2CH2)2NH, Bz2NH, N-morpholine] was prepared starting from suitable precursors. The syntheses and spectroscopic characterizations of the two new complexes trans-[PtCl2(N-morpho...

A series of mixed-tris complexes of general formula [ML′L2](ClO4)2·H2O [M = Ru or Os; L′ = 2,2′-bipyrazine (bpyz) or 2,2′-bipyrimidine (bpym) and L = 2-(phenylazo)pyridine (papy) or 2-(m-tolylazo)pyridine (tapy)] has been prepared and characterized by physicochemical and spectroscopic metho...

The crystal structure of the title compound [Fe(bpz)3](ClO4)2 · H2O (bpz=2,2′-bipyrazine) has been determined by a single crystal X-ray diffraction study at 293(2) K. The complex is monoclinic, P21/c, a=17.263(3), b=9.983(2), c=17.921(4) Å, β=107.94(3)°, V=2938.3(10) Å3, Z=4, R=0.073 and Rw=...

The photooxidation of organic sulphides with excited Ru(bpz)32+ (bpz = 2,2′-bipyrazine) results in the formation of sulphoxides and sulphones in aqueous CH3CN and the reaction proceeds via an electron transfer mechanism.

New 6-methyl-2,2′-bipyrazinyl tripodal ligand 5 and pentadendate ligand 6 have been obtained in a one step alkali metal ion assisted reaction or in two steps from a 6-bipyrazine derivative. Eu(III) and Tb(III) complexes have been synthesized. UV-Vis spectra show strong absorbance of both comple...

Owing to its relatively high basicity (pKa1 = 3.37), the title ligand yields M(CO)4 chelate complexes (M = Cr, Mo, W) which have both metal-to-ligand charge transfer absorption maxima at longer wavelengths than corresponding 2,2′-bipyrimidine and 2,2′-bipyrazine compounds. After 4,4′-bipyrimi...

BackgroundCobalt toxicity-related cardiomyopathy in hip arthroplasty has recently been reported in the literature. The purpose of this review is to identify and assess available published evidence of cardiomyopathy in hip arthroplasty patients and to derive recommendations for management.

The raw starch digesting type of amylase (RSDA) presents greater opportunities for process efficiency at cheaper cost and shorter time compared to regular amylases. Chemical modification is a simple and rapid method toward their stabilization for a wider application. RSDA from Aspergillus carbon...

ZIF-8 (zinc-methylimidazolate framework-8), one of the zeolitic imidazolate frameworks (ZIFs), has been used for the removal of phthalic acid (H2-PA) and diethyl phthalate (DEP) from aqueous solutions via adsorption. The adsorption capacity of the ZIF-8 for H2-PA was much higher than that of a c...

A considerable effort has been devoted to elucidating the roles of chloride in oxidative degradation and chlorination of dyes. However, few investigations are available on kinetic analysis and transformation pathways of secondary degradation byproducts of dyes in saline wastewater treatment. Her...

The adsorption of phthalic acid (PA) and 4-methyl phthalic acid (4MPA) on a silver sol surface is studied with surface-enhanced Raman spectroscopy as a function of pH. It is shown that at every pH value studied the (4M)PA molecules are adsorbed on the surface as dicarboxylate. The spectra indica...