Glycidaldehyde (GDA) is a bifunctional alkylating agent that has been shown to be mutagenic in vitro and carcinogenic in rodents. However, the molecular mechanism by which it exerts these effects is not established. GDA is capable of forming exocyclic hydroxymethyl-substituted etheno adducts on ...

DNA which has been exposed to 2-haloethylnitrosoureas has been shown to contain the chemical crosslink 1-(N3-deoxycytidyl), 2-(N1-deoxyguanosinyl)-ethane [W.P. Tong, M.C. Kirk and D.B. Ludlum, Cancer Res. 43, 3102 (1982)]. We have hypothesized that this structure is formed by an initial attack o...

The ability of a number of compounds that act as inactivators of O6-alkylguanine-DNA alkyltransferase (AGT) to sensitize human tumor cell lines to the effects of N,N′-bis(2-chloroethyl)-N-nitrosourea (BCNU) were examined. The AGT inactivators tested included O6-benzylguanine (BG) and its 8-aza-...

The chloroethylnitrosoureas are useful antitumor agents which evidently exert a significant part of their cytotoxic action through the formation of a unique 1-(3-deoxycytidyl),2-(1-deoxyguanosinyl)ethane cross-link in DNA. It has been suggested that this cross-link is formed from 06-(2-chloro-et...

The commercial dye C.I. Acid Black 194 was analyzed by reversed-phase HPLC, Capillary Zone Electrophoresis and Micellar ElectroKinetic Chromatography under different operative conditions, with the scope to detect the impurity distribution typical of any production processes and synthetic batch. ...

SummaryLipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking BAT Comparative Gene Identification-58 (CGI-58), a lipolytic activator essential for the stimulated LD lipolysis, ...

The thermal behaviour and chemical structure of densified products of two Victorian brown coals prepared with NaOH addition were analysed by differential gravimetric analysis/differential thermal analysis (DGA/DTA) and Fourier transform infrared spectroscopy (FTIR).Acid washing of coal led to lo...

Acidic and basic porous polymers were facilely prepared through the radical copolymerization of target monomers and the crosslinker divinylbenzene (DVB), respectively. Combination of these polymers endowed highly efficient, heterogeneous recyclable acid-base binary catalysts for cascade deacetal...

ABSTRACTForage sorghum [Sorghum bicolor (L.) Moench] is a viable alternative to corn silage (Zea mays L.) in double cropping rotations with forage winter cereals in New York due to a later planting date and potentially earlier harvest date of forage sorghum than is typical for corn silage. Our o...

In this work, polybenzoxazines based on phenol and aniline were prepared by curing as-synthesized and purified monomers in the presence of aromatic diboronic acid, BDBA. Condensation reactions between BOH groups of diboronic acid and phenolic OH groups of benzoxazine took place during curing onl...

The acquaintance of arsenic concentrations in rice grain is vital in risk assessment. In this study, we determined the concentration of arsenic in 282 brown rice grains sampled from Hainan Island, China, and discussed its possible relationships to the considered soil properties. Arsenic concentr...

A novel variable pH control operation strategy was developed for maximizing energy and resource recovery from food waste by integrating the ultra-fast hydrolysis and lipid fermentation. Food waste after fast hydrolyzed by homemade hydrolytic enzymes, the separated solids can be directly applied ...

The phenolic substances in sugar cane juice affect the color value of white sugar. A magnetic chitosan-modified-diatomite (MCMD), as a new type of clarifying agent for sugar, prepared via a co-precipitation method combined with cross-linking treatment was firstly used to adsorb two primary pheno...

The aim of the study was to compare changes in the chemical compositions and bioactive compounds of germinated rough rice and germinated brown rice. Ungerminated rice (brown rice) and germinated rice extract powder were also prepared, for comparison purposes. In general, the concentration of cru...

Brown-rot fungi are the wood-decay basidiomycetes and have ability to break down plant cell wall carbohydrates. It has been suggested that degradation of pectin is important for the initial stages of brown rot. We purified an endo-polygalacturonase (FpPG28A) from the brown-rot fungus Fomitopsis ...

Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion. The development of brown-like adipocytes in WAT is controlled by hypothalamic NPY ne...

ABSTRACTKelp meal (KM) is a supplement made from the brown seaweed Ascophyllum nodosum, known to bioaccumulate iodine (I) and to be the richest source of phlorotannins, which can inhibit ruminal proteolysis and microbial growth. The objective of this study was to investigate the effects of KM on...

Mesoporous silica MCM-41 and SBA-15 containing propyl sulfonic acid groups were synthesized according to the literature and were characterized by X-ray diffraction, N2 adsorption and the H+ exchange capacities of the sulfonic acid groups were titrated. The esterification reaction of glycerol wit...

Murine and rat monoclonal antibodies (MAbs) were purified to 90–95% homogeneity from ascites in a single step using an ABx liquid chromatography column which utilizes a silica-based mixed-mode ion-exchange matrix. The resulting MAbs were highly immunoreactive reflecting the mild conditions used...

The abilities of several high-performance liquid chromatography (HPLC) anion-exchange packings to separate DNA restriction fragments, ranging in size from 50 to 23 000 base pairs, were studied. The ion exchangers investigated include the porous packings Protein-Pak DEAE-5PW, Nucleogen-DEAE 4000-...