The abilities of halothane and the fluoroethane chlorofluorocarbon (CFC) substitutes, FC-123, FC-133a, FC-124, FC-134a and FC-125, to stimulate cytochrome P450 activities and 2-chloro-1,1-difluoroethene (CDE) defluorination in hepatic microsomes from phenobarbital-treated rabbits were compared. ...

Thermodynamic functions C°p, S°, (H°-H°o)/T, -(F°-H°o)/T have been calculated≠ for three asymmetric 1-halo-2-fluoroethanes (1-chloro-2-fluoroethane, 1-bromo-2-fluoroethane, 1-iodo-2-fluoroethane) in the ideal gas state from 298.15 to 1000°K at 1 atm pressure. The restricted internal rota...

Aqueous polyalkylated imidazoles have gained interest as potential CO2 capture solvents due to their high oxidative stability and low vapor pressures compared to traditional amines. In this work, 21 aqueous solutions of polyalkylatedimidazoles were screened as absorbents for CO2 capture and four...

In the framework of this report, investigation of aggregation behavior, solubilization activity and antimicrobial properties of novel cationic amphiphiles of 1-(2-hydroxyethyl)alkylimidazolium bromide homologous series were carried out. Using conductometry and fluorescence spectroscopy it was sh...

We report the synthesis of two new hydrophilic random copolymers prepared by free radical polymerization of 1-(2-methacryloyloxyethyl carbamoyloxy-2-ethyl) imidazole and N-isopropylacrylamide in 5:95 (IMU-NIPAm-5) and 10:90 (IMU-NIPAm-10) molar ratios and the study of their characteristic thermo...

An efficient and simple method for C2-functionalization of 2-unsubstituted imidazole N-oxides has been developed. It consists at the condensation of 2-unsubstituted imidazole N-oxides with aldehydes and CH-acids. This method permits broad variations in the structure of starting materials.

A series of novel soluble PEG600-imidazole compounds were synthesized and investigated as thermal latent catalysts for curing diglycidyl ether of bisphenol A (DGEBA). Based on the results of thermal latency and storage stability, the PEG600-imidazole catalyst showed better thermal latency than u...

Two organotin(IV) carboxylates of (E)-3-(2-nitrophenyl) propenoic acid (HL), [Ph3SnL]n (1) and {[Bu2SnL]2O}2 (2), have been synthesized. All the complexes were characterized by elemental analysis, FT-IR and NMR (1H, 13C) spectroscopy. In addition, the molecular structures of 1 and 2 have been de...

(E)-3-(4-Chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one is synthesized by reacting 4-fluoroacetophenone and 4-chlorobenzaldehyde in ethanol in the presence of sodium hydroxide. The structure of the compound was confirmed by IR and single crystal X-ray diffraction studies. FT-IR spectrum of (E)-...

SLC-0111 (4-(4-fluorophenylureido)-benzenesulfonamide) is the first carbonic anhydrase (CA, EC 4.2.1.1) IX inhibitor to reach phase I clinical trials as an antitumor/antimetastatic agent. Here we report a kinetic and X-ray crystallographic study of a congener of SLC-0111 which incorporates a thi...

Summary:1-Aminobenzotriazole (ABT) is widely used as a non-specific inhibitor of animal cytochrome P450 (CYP). In the present study, the inhibitory effect of ABT was investigated on drug oxidations catalyzed by human CYP isoforms. This inhibitory effect was compared with that of SKF-525A, anothe...

Recent investigations demonstrated that administration of 1-aminobenzotriazole (ABT) to rats caused adrenal gland enlargement. Studies were done to pursue the mechanism(s) involved. Preliminary experiments revealed that the adrenal enlargement caused by ABT was associated with a decline in plasm...

Studies were done to determine the effects of a P450 suicide inhibitor, 1-aminobenzotriazole (ABT), on adrenal steroid and xenobiotic metabolism. Incubation of guinea pig adrenal microsomes with ABT plus an NADPH-generating system caused a time-dependent decline in total P450 concentrations. The...

Summary:1-Aminobenzotriazole (ABT) is extensively used as a non-specific cytochrome P450 (CYP) inhibitor. In this study, the inhibitory effect of ABT on CYP-dependent drug oxidations was investigated in human liver microsomes (HLM) and compared with that of SKF-525A, another non-specific inhibit...

The crystals (benzaldehyde 4-nitro phenyl hydrazone (BPH)) appropriate for NLO appliance were grown by the slow cooling method. The solubility and metastable zone width measurement of BPH specimen was studied. The material crystallizes in the monoclinic crystal system with noncentrosymmetric spa...

High concentrations of Ethyl-[4-(4-nitro-phenylazo)-phenyl]-(2-oxiranylmethoxy-ethyl)-amine (ENPMA) chromophores were linked covalently to two different kinds of SiO2 matrices prepared by the sol–gel method. The matrices differed in their reticulation level, determined by the organometallic pre...

This work presents the synthesis and characterization of a novel compound, 3-(4-Methoxy-phenyl)-2-(4-nitro-phenyl)-acrylonitrile (abbreviated as 3-(4MP)-2-(4-NP)-AN, C16H12N2O3). The spectroscopic properties of the compound were examined by FT-IR, UV–vis and NMR (1H and 13C) techniques. FT-IR s...

FT-IR and FT-Raman spectra of herbicidal molecule 4-Nitro phenyl phenylether were recorded and analyzed. The equilibrium geometry, various bonding and harmonic vibrational wavenumbers have been calculated with the help of density functional theory (DFT) method. The assignments of the vibrational...

Multistage enantioselective liquid–liquid extraction (MELLE) of amino-(4-nitro-phenyl)-acetic acid (PGL) enantiomers using CuPF6{(S)-BINAP} as extractant was studied experimentally in a countercurrent cascade of ten centrifugal contactor separators. Based on an equilibrium stage approach, an in...

The mechanism and kinetic aspects of the retro-ene reaction of the Allyl n-propyl sulfide and its deuterated derivative were studied using four different types of density functional theory methods with eight different levels of the basis sets. The activation energies were determined at 550.65 K....