The development of the first enantioselective total synthesis of altersolanol N is reported. The decisive step of the synthesis is the enantioselective formation of the tetrahydroanthraquinone nucleus by a [4 + 2]-cycloaddition in high yield and with excellent diastereo- and enantioselectivity (...

We classify gradings by arbitrary abelian groups on the classical simple Lie superalgebras P(n), n≥2, and on the simple associative superalgebras M(m,n), m,n≥1, over an algebraically closed field: fine gradings up to equivalence and G-gradings, for a fixed group G, up to isomorphism. As a coro...

The aim of this work was to evaluate the vermicompost humic acid (HA) stimulatory effects on the N-uptake kinetics and the N metabolism of rice plants under high and low N-NO3- or N-NH4+ supply in nutrient solution. Plants were grown in a growth chamber, and at 21 days after germination, they we...

A novel N,N',N',1-tetraacetyl-4,6-dimethoxy-1H-indole-2-carbohydrazide 5, bearing four N-acetyl groups (N-COCH3) as cation binding sites was successfully synthesized by the reaction of readily available 4,6-dimethoxy-1H-indole-2-carbohydrazide 4 with acetic anhydride in dimethyl formam...

Infinite dilution activity coefficients and gas-to-ionic liquid partition coefficients are reported for >40 different organic compounds dissolved in N-[2-(N′,N′-dimethylamino)ethyl]-N,N-(dimethyl)-1-propanaminium bis(trifluoromethylsufonyl)imide, N-[2-(N′,N′-dimethyl-amino)ethyl]-N,N-(dimeth...

In this work we numerically calculate cross sections of the reactions 6Li(n,n′γ)6Li and 7Li(n,n′γ)7Li reactions in the region of neutron kinetic energy En=0.5−20 MeV. Neutron-nucleus interaction is defined in terms of the three-body problem wherein the target-nucleus is a bound two-body syst...

High activity and selectivity of the hierarchical H-Ymmm zeolite in the synthesis of practically important pyridines (by interaction of C2–C4 alcohols with formaldehyde and ammonia, cyclocondensation of acetaldehyde and propanal with ammonia), dialkyl quinolines (by reaction of aniline with ald...

(−)-δ-N-normethylskytanthine (1) has been synthesised from (1R,4R,1′S)-2-(phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene (2) which undergoes a ketene-amino-Claisen rearrangement by reaction with dichloroketene to generate (1S,6R,1′S)-3-(phenylethyl)-5,5-dichloro-4-keto-3-azabicyclo[4.3.0]non-7-en...

Mild non-ionic detergents are indispensable in the isolation of intact integral membrane proteins and protein-complexes from biological membranes. Dodecylmaltoside (DM) belongs to this class of detergents being a glucoside-based surfactant with a bulky hydrophilic head group composed of two suga...

Acetone, one of the most common VOCs, could cause serious air pollution and threat the human health when someone is exposed to certain concentration of acetone. Thereof, acetone detection and elimination in the air was significant to prohibit the hazard of acetone. Acetone adsorbed to (BeO)12, (...

IntroductionResistance of cancer cells to chemotherapy has become a worldwide concern. Naturally occuring isoflavonoids possess a variety of biological activities including anti-cancer effects. The present study was aimed at investigating the cytotoxicity and the modes of action of three natural...

The title compounds are prepared from the readily available enantiopure 6-alkyl- or 6-aryl-2-tert-butyl-6-trifluoromethyl-1,3-dioxan-4-ones with cis disposition of the tert-butyl and trifluoromethyl groups. Lithium enolates of these dioxanones are added to di-tert-butyl-azo-dicarboxylate to give...

A reversed-phase (C18) HPLC method with diode-array detection was developed for the separation and determination of methylglyoxal bis(amidinohydrazone) (mitoguazone) and seven closely related aliphatic analogs thereof, namely the bis(amidinohydrazones) of glyoxal, dimethylglyoxal, ethylmethylgly...

Diethylglyoxal bis(guanylhydrazone) (DEGBG), a novel analog of the antileukemic agent methylglyoxal bis(guanylhydrazone) (MGBG) was synthesized. It was found to be the most powerful inhibitor of yeast S-adenosylmethionine decarboxylase (AdoMetDC) so far studied (Ki approx. 9 nM). This property, ...

2-[Bis(methylthio)methylene]-1,3-indanedione has been shown to be a useful three carbon 1,3-dielectrophilic synthon for the highly efficient regiospecific synthesis of a variety of indenofused five- and six-membered heterocycles via heteroaromatic annulation. The methodology has been further ela...

Chemosensitization of bifunctional alkylators by misonidazole (MISO) and related nitroimidazoles in vitro has been shown to require hypoxic exposures. Presumably, reductive metabolism of the nitroimidazole under hypoxic conditions results in generation of a chemosensitizing intermediate(s) in a ...

It is currently believed that the biological activity of such therapeutic 5-nitroimidazoles as metronidazole is mediated by a short-lived, highly toxic species that arises from nitro group reduction. We found that the 5-nitroimidazole, 1-methyl-4-phenyl-5-nitroimidazole (5-NO2), is at least 1000...

The biological effects of 1-methyl-2-nitrosoimidazole (INO), the 2 electron reduction product of biologically active 1-methyl-2-nitroimidazole, were examined in HT-29 human colon cancer cells by clonogenic assay and glutathione (GSH) determination. INO was very toxic towards HT-29 cells and was ...

1-Methyl-2-nitrosoimidazole (INO), the 2-electron reduction product of 1-methyl-2-nitroimidazole (INO;), was prepared by electrochemical reduction of INO2 to 2-hydroxylamino-1-methylimidazole (INHOH), followed by back oxidation with iodine. Although stable in crystalline form, INO reacted in wat...

The cellular reduction of 2-nitroimidazoles under hypoxic conditions can lead to cell killing. One of the postulated toxic intermediates is the two-electron reduction product, the nitrosoimidazole. 1-Methyl-2-nitrosoimidazole (INO) was used as a model to study the reactivity of 2-nitrosoimidazol...