In this paper, a novel surfactant, N-butoxypropyl-S-[2-(hydroxyimino) propyl] dithiocarbamate ester (BOPHPDT) was first synthesized and introduced as a flotation collector for copper minerals. The micro and bench-scale flotation results demonstrated BOPHPDT exhibited superior flotation performan...

Long-lived radical cation dimers of diethyl sulfide, di-n-propyl sulfide and di-n-butyl sulfide have been prepared via an association reaction of the dialkyl sulfide radical cation with the dialkyl sulfide in the cell of a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Und...

Recent studies of temperature-responsive polymers, such as poly(N-isopropyl acrylamide) (PNIPAM), have revealed opportunities to utilise the smart materials to enhance the flotation recovery of valuable fines. PNIPAM undergoes a hydrophilic-to-hydrophobic transition when heated above a lower cri...

Collector performance in the base metal sulphide (BMS) and platinum group mineral (PGM) flotation industry depends on both the polar head group and the non-polar hydrocarbon chain length of the collector. These affect the strength of the collector-mineral bond, as well as the extent of hydrophob...

Dialkyl dithiophosphates (DTP) are commonly used as primary or secondary collectors in base metal sulfide and platinum group mineral flotation. However, evidence in the literature suggests that, under basic conditions, DTP does not adsorb onto certain minerals. The purpose of this study was to i...

Direct CH functionalization of quinoline N-oxides with arylboronic acids is achieved using KMnO4 as the sole and efficient oxidative system. This method provides an efficient protocol to construct regioselectively 2-arylquinoline N-oxides via radical cross-coupling reaction in moderated to good ...

Synthesised vanadium-coordinated N,N-bis(o-hydroxybenzaldehyde)phenylene diamine catalyst, [VO(sal-HBPD)] and supported catalyst, p[VO(sal-HBPD)] were employed for the oxidation of quinoline. The use of [VO(sal-HBPD)] and p[VO(sal-HBPD)] for the oxidation of quinoline, (Quinoline-to-H2O2 ratio 1...

The study provides a technological method for the removal of nitrogen compounds from fuels, via oxidation and extractive adsorption. The use of batch process resulted in lack of specificity of the quinoline oxidation reaction with several products produced via ring-opening while the flow micro-r...

Drugs currently available for visceral leishmaniasis treatment are potentially toxic, have to be administered by parenteral route and frequently give rise to drug resistance, due to the involvement of P-glycoproteins (P-gp) in Leishmania. The purpose of this study was to investigate a possible i...

The antileishmanial evaluation of more than one hundred 2-substituted quinolines led us to identify three compounds for further studies: compound 1 (2-n-propylquinoline), compound 2 (2-(2methoxyethenyl)quinoline) and compound 3 (2-(2-hydroxyprop-2-enyl)quinoline). The final selection of a potent...

A high-performance liquid chromatographic method was developed for the specific determination of 2-n-propylquinoline, a new anti-leishmaniasis drug, in plasma and liver homogenates of mice. 2-n-Propylquinoline was extracted with methyl-tert.-butyl ether with quinoline as internal standard. Separ...

2-n-propylquinoline (2-n-PQ) had shown interesting in vivo antileishmanial activities after administration by oral route on leishmaniasis animal models. However, the lipophilic properties of this compound avoid its use by intravenous route, this route being indicated in cases of severe visceral ...

The synthesis of 2-propylquinolines, a family of antileishmanial agents, is reported. Among the pathways explored, the 3-component Povarov reaction between butyraldehyde, aromatic amines and ethyl vinyl ether in trifluoroethanol (TFE), followed by an oxidation, offers a convenient entry to 2-pro...

Microwave-assisted approach was utilized as green approach to access a series of 2-propylquinoline-4-carbohydrazide hydrazone derivatives 10a-j of aromatic and heteroaromatic aldehydes in highly encouraging yields. It involved four steps reaction which was initiated with ring opening reaction of...

We have investigated the potential neurotoxicity of the catecholamine depleting agent 1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol (TMIQ) in SH-SY5Y neuroblastoma cells. TMIQ induced a time and dose related inhibition of 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; thiazo...

The anaerobic degradation of quinoline, isoquinoline and 2-methylquinoline was investigated under nitrate-reducing conditions with acclimated activated sludge. Quinoline was completely transformed during degradation with an optimum COD/NO3–N ratio of 7. Isoquinoline and 2-methylquinoline were a...

Eight previously undescribed isoquinoline alkaloids, mucroniferanines H-M, together with 16 known isoquinoline alkaloids, were isolated from Corydalis mucronifera Maxim.. The structures of the previously undescribed compounds were elucidated by interpretation of 1D and 2D NMR spectroscopic and H...

The review (Part 1) deals with the synthesis of 2-pyridone methides and benzo-fused analogs. Methides that are unsubstituted at the nitrogen atom are mainly synthesized from the corresponding pyridine bases by reactions at o- or α-positions, from N-oxides or by ring formation or transformation....

One main focus of the review (Part 2) is spectral and physicochemical properties of both N-unsubstituted methides and anhydrobases, including tautomerism and stability. In the sections on chemical reactivity, reactions upon the α-position as well as ring formation and transformation are dominan...

We designed and synthesised a series of novel chalcones, incorporating the heterocyclic framework of 2,2-dimethyl-2,3-dihydro-4(1H)-quinolinone, which was prepared via Sonogashira coupling of a substituted orthoaniline under aqueous conditions using Pd catalysis followed by acid-mediated cyclisa...