(6-Oxo-6H-pyridazin-1-yl)phosphoric acid diethyl esters (3) are efficient and selective coupling agents for equimolar esterification of carboxylic acids and alcohols. Esterification of aliphatic and aromatic carboxylic acids with aliphatic and aromatic alcohols using 3 afforded the corresponding...

Hereby we report new reaction conditions to convert benzoic acids and more general (hetero)aromatic carboxylic acids into the corresponding n-heptyl esters by applying Novozym-435 as the biocatalyst in cyclohexane as the solvent. Very good yields are obtained in the esterification of a plethora ...

We report on the studies performed on Morpholinium 2-chloro-4-nitrobenzoate (M2C4N), a second order nonlinear optical (NLO) material, which has been proved to crystallize with chiral structure as compared to its other two variants. The synthesized powder was studied for its composition, crystall...

Two new copper(II) complexes [Cu(L1)2(TEMED)] (1) and [Cu(L2)2(TEMED)] (2) (L1 = 4-chloro-2-nitrobenzoate, L2 = 5-chloro-2-nitrobenzoate, TEMED = N,N,N′,N′-tetramethylethylenediamine) have been obtained by the addition of TEMED to hydrated Cu(II) benzoates, in methanol–water (4:1, v/v) mixtur...

A new 2-(2′-hydroxyphenyl)quinazolin-4(3H)-one derived acylhydrazone (QP) was designed and synthesized as a fluorescent sensor. In Tris ∙ HCl buffer (10 mM, pH 7.4)/ethanol (1/9, v/v) solution, QP exhibits a highly selective fluorescence response to Al3 + over other metal ions with a significan...

2-amino-3-(4-hydroxyphenyl)N-[(1E)-(2-hydroxyphenyl)methylene]propanehydrazide (amph, LH2) and Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized and characterized based on the elemental analyses, molar conductance, TGA, magnetic susceptibility, 1H and 13C NMR, UV–Vis, IR, EPR...

The excited-state intramolecular proton transfer (ESIPT) dynamics of 2-(4′-Amino-2′-hydroxyphenyl)-1H-imidazo-[4,5-c]pyridine (AHPIP-c) has been studied by using density-functional theory and time-dependent density-functional theory method. Three kinds of different polar aprotic solvents, incl...

Sugar epoxides are transformed in almost quantitative yields, under mild reaction conditions, into their corresponding unsaturated monosaccharides by reaction with O,O-dialkylphosphoroselenoic acids salts. A mechanism involving the formation of a penta-coordinate phosphorus intermediate is propo...

Multidrug resistance (MDR) refers to the cross-resistance of cancer cells to one drug, accompanied by other drugs with different mechanisms and structures, which is one of the main obstacles of clinical chemotherapy. Overexpression of P-glycoprotein (P-gp) was an extensively studied cause of MDR...

A new method for destroying silicon tetrachloride has been proposed, which is based on a microwave plasma jet that operates at atmospheric pressure using hydrogen as work gas. The influence of input power (P) and silicon tetrachloride concentration (φ) on the percent destruction and removal of ...

The α-haloenones undergo cine-substitution upon reaction with phenolic reagents under basic conditions. A convenient method for the synthesis of push–pull aroxyenones was developed based on this reaction.

Thirty six new N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothioamides were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity was established in three seizure models i.e. MES, scMET and 6 Hz model. The most active compo...

A series of novel phenol ether derivatives were designed, synthesized, and evaluated as non-covalent proteasome inhibitors. Most compounds exhibited moderate to excellent proteasome inhibitory activity. In particular, compound 18x proved to be the most potent compound (chymotrypsin-like: IC50 = ...

The direct esterification of 1-hydroxy-3-methyl-3-phospholene 1-oxide with substituted phenols under microwave irradiation in the presence of 10% of [bmim][PF6] affords the corresponding aryl phosphinates in 52–64% yields.

An efficient asymmetric ring opening reaction of azabenzonorbornadienes with various phenols using Palladium/(R,R)-DIOP complex has been demonstrated, the reaction afforded the corresponding products in excellent yields (80–95%) with moderate enantioselectivities (50–64% ees). The syn-configur...

Chloroperoxidase (CPO) is a hybrid of two different families of enzymes, peroxidases and P450s. However, it is poorly understood on CPO's multiple catalytic functions. Herein, phenol was selected as a model substrate to investigate the multiple catalytic roles of CPO. Results showed that ph...

Brominated phenolic compounds (BPCs) are a class of persistent and potentially toxic compounds ubiquitously present in the aquatic environment. However, the origin of BPCs is not clearly understood. In this study, we investigated the formation of BPCs from natural manganese oxides (MnOx)-catalyz...

We describe here the synthesis of the allyl Lea trisaccharide antigen as well as that of an analogue of the Lex trisaccharide antigen, in which the galactose residue has been replaced by a glucose unit. Although successful fucosylations at O-4 of N-acetylglucosamine acceptors have been reported ...

BackgroundBinding of chemokines to glycosaminoglycans (GAGs) is a crucial step in leukocyte recruitment to inflamed tissues.

Hexasaccharide β-D-Galp-(1→ 2)-[β-D-Galp-(1 → 3)]-β-D-Galp-(1 → 6)-[β-D-Galp-(1 → 2)-β-D-Galf-(1 → 4)]-D-GlcNAc (1) was found O-linked in mucins of Trypanosoma cruzi epimastigotes and metacyclic trypomatigotes. Studies on the biological pathways and functionalities of the mucin oligosa...