The reactions of 2,3-bis(diethylsilyl)thiophene 1 with alkynes such as diphenylacetylene, 3-hexyne and phenylacetylene in the presence of a catalytic amount of Pt(PPh3)4 in benzene at 80 °C proceeded to give products 2, 3, and 6a,b, respectively. Treatment of a mixture consisting of 1 and 1,4-d...

The synthesis and characterization of a new class of ansa bis(indenyl) complexes of zirconium and hafnium is described. Two indenyl moieties are linked at the 1-,1′-positions via a 1,2-bis(dimethylsilyl)benzene unit. The ligand precursor was prepared via three reaction steps including Grignard ...

The reactions of 3,4-bis(dimethylsilyl)thiophene (1) and 2,3,4,5-tetrakis(dimethylsilyl)thiophene (17) with alkynes and alkenes have been reported. The reactions of 1 with alkynes such as diphenylacetylene, 3-hexyne, phenyltrimethylsilylacetylene, and trimethylsilylacetylene, in the presence of ...

The polyadenosine-diphosphate-ribose polymerase 14 (PARP14) has been implicated in DNA damage response pathways for homologous recombination. PARP14 contains three (ADP ribose binding) macrodomains (MD) whose exact contribution to overall PARP14 function in pathology remains unclear. A medium th...

A novel class of N-substituted tetrahydropyridine derivatives was found to have multiple kinetic mechanisms of monoamine oxidase A inhibition. Eleven structurally similar tetrahydropyridine derivatives were synthesized and evaluated as inhibitors of MAO-A and MAO-B. The most potent MAO-A inhibit...

A full account of synthetic efforts toward the indeno-tetrahydropyridine core of haouamine A is presented. Initial failed strategies led to the unexpected discovery of a mild abnormal Chichibabin pyridine synthesis and provided knowledge and inspiration for the development of a cascade annulatio...

Inhibitory effects of some MPTP and MPP+ analogues on rat brain MAO activity were studied to further clarify the structure-activity relationships of MPTP neurotoxicity. Of the analogues tested, 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine (CPTP), 4-(4-chlorobenzyl)-pyridine (CBP), 4-benzylpyrid...

Polysubstituted 1,2,3,4-tetrahydropyridines were synthesized through hydroalkylation of electron-deficient alkynes, followed by double Mannich addition reactions, which is a practical protocol with atom efficiency and good substrate scope.

The reactivity of stable tertiary enamides in nucleophilic addition reaction with various in-situ generated imines was explored. Under very mild conditions, formyl-bearing tertiary enamides reacted with both aromatic and aliphatic amines to form imine intermediates. In the absence or presence of...

Diethylgermanium-diphenylsilicon oxide [(Et2Ge)O(Ph2Si)O]2 has been prepared by reaction of diethylgermanium dichloride and diphenyldihydroxysilane. Spectra and X-ray analysis showed the presence of a puckered eight-membered silicon—germanium—oxygen ring. The ethyl groups of the germanium atom...

The ip LD50s of N-(2,3-dimercaptopropyl)phthalamidic acid (DMPA) and British Anti-Lewisite (BAL) were 0.819 and 1.48 mmol/kg, respectively, in male albino mice. The ip ED50 of DMPA and BAL for prevention of the lethal effects of 0.15 mmol NaAsO2/kg was 0.022 and 0.169 mmol/kg, respectively. DMPA...

Currently, fossil fuels are used in diesel engines and are essential in industrialized areas. However, the use of petroleum-based diesel increases environmental pollution. To solve this worldwide problem, transesterified vegetable oil grown in set-aside land can serve as a renewable energy resou...

Heterogeneous transesterification of vegetable oils offers an environmentally more attractive option for biodiesel production compared to the conventional homogeneous processes. Thus, the metal doped methoxide catalyst was developed in the present study which aims to improve the transesterificat...

The use of methanol as a fuel additive and in methyl t-butyl ether (MTBE) production has renewed interest in the search for improved methanol processes. A slurry phase concurrent synthesis of methanol using a potassium methoxide/copper chromite mixed catalyst which operates under relatively mild...

We report the formation of potassium methoxide from the reaction of methanol with a monolayer of potassium adsorbed on a Ru(001) surface. The vibrational spectrum of KOCH3 is characterized by high resolution electron energy loss spectroscopy with a K-O stretch at 180 cm−1, a C-O stretch at 1050 ...

Carbon monoxide (CO) hydrogenation in the liquid medium was carried out at 373 K and 423 K with an initial pressure of 5 MPa using a catalyst composed of a metal carbonyl and potassium methoxide. Among the metal carbonyls tested, nickel tetracarbonyl showed a peculiarly high production of methan...

Catalysts prepared from potassium hydroxide and methanol were tested for methanol carbonylation with CO in the range of 70-90oC and 20-25 kg/cm2(g). Methyl formate was produced selectively under the studied conditions. Lower temperatures and higher pressures enhanced the conversion of CO. Water ...

The biodiesel industry has been dealing with the issue of glycerol oversupply for some time, leading to blossoming research regarding its valorisation to yield value-added derivatives. This work presents the production of glycerol carbonate through the transesterification of glycerol with dimeth...

Sodium and potassium methoxides are used as an intermediary for a variety of products in several industrial applications. For example, current production of so called “1G-biodiesel” relies on processing a catalytic reaction called “transesterification”. This reaction transforms lipid resourc...

A study of the soybean oil transesterification reaction with dimethyl carbonate (DMC) catalyzed by potassium methoxide prepared through recrystallization process in presence of methanol was done. Reaction variables were analyzed viz. temperature of 40, 60 and 80 °C, DMC to oil molar ratio of 2:...