New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H-imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o, m, p)-substituent in the phenyl ring; an analogous series of p-substitu...

New fluorescent probe Tb(III) (7-carboxymethoxy-4-methylcoumarin)2(SCN) (C2H5OH)(H2O) was synthesized and characterized by spectroscopy and thermal analysis. The absorption and fluorescence spectra of 7-carboxymethoxy-4-methylcoumarin (CMMC) and Tb(III)–CMMC complex have been measured in differ...

Three new cadmium(II) coordination polymers {[Cd(bipy)(cpa)(H2O)]·2H2O}n (1), {[Cd(phen)(cpa)]·3H2O}n (2) and [Cd(cpa)]n (3) (bipy = 2,2′-bipyridine, phen = 1,10-phenanthroline, H2cpa = (4-carboxymethoxy-phenyl)-acetic acid) were synthesized and characterized. The cpa ligands exhibit the vers...

Seven new metal–organic frameworks based on 3,4-bis(carboxymethoxy)benzoic acid (H3bcba), 3,5-bis(4-pyridyl)-1,2,4-triazolyl (Hbpt) or 4,4′-bipyridyl (4,4′-bipy), named [Sr3(bcba)2(H2O)3]n (1), [Sr(Hbcba)(H2O)3]n (2), [Zn(Hbcba)(H2O)2]n (3), [Zn3(bcba)2(Hbpt)2(H2O)2]n (4), [Zn3(bcba)2(4,4′-b...

Three microporous Zn coordination polymers, [Zn3(OH)2(TCBA)(4,4′-bpy)]·5.5H2O (1), [Zn3(OH)2(TCBA)(4,4′-bpy)1.5]·5H2O (2), and [Zn4(TCBA)2(4,4′-bpy)2(H2O)8]·11H2O (3) (H4TCBA = 3,4,5-tris(carboxymethoxy)benzoic acid, 4,4′-bpy = 4,4′-bipyrdine), have been hydrothermally synthesized and st...

7-Methylbenz[a]anthracene (7-MBA) was metabolized stereoselectively by rat liver microsomes to form five optically active dihydrodiols as the predominant metabolites. The dihydrodiols were purified by a combination of reversed-phase and normal-phase high performance liquid chromatography (HPLC)....

Hydroxylation of meso-methyl groups with subsequent formation of reactive benzylic esters bearing a good leaving group (e.g. sulfate) was proposed as a possible biochemical mechanism of activation and tumorigenicity of methyl-substituted polycyclic aromatic hydrocarbons (PAHs). In support of thi...

The environmentally widespread polycyclic aromatic hydrocarbon (PAH) benzo[k]fluoranthene is a potent AHH inducer. This has been proven by recording the benz[a]anthracene metabolite profile in the rat liver by means of gas chromatography/mass spectrometry (GCMS) technique. Even a total dose of 3...

IntroductionTrophoblast proliferation and invasion are essential for embryo implantation and placentation. Protein glycosylation is one of the most common and vital post-translational modifications, regulates protein physical and biochemical properties. FUT8 is the only known fucosyltransferase ...

BackgroundEpidermal stem cells (ESCs) are keratinocytes that reside in the basal layer of the epidermis and mediate epidermal homeostasis. Insulin-like growth factor 1 (IGF-1) signaling through its receptor (IGF-1R) has been identified as an important regulator in rodent skin development and dif...

IntroductionPreclinical research suggests a role of Glucagon Like Peptide-1 Receptors (GLP-1R) on the regulation of human bronchial tone. We investigated the effect of GLP-1R agonists on lung function of Type 2 Diabetes Mellitus (T2DM) population without co-existing chronic obstructive respirato...

The important role of insulin-like growth factor-1 receptor (IGF-1R) in tumorigenesis has been well established. The classical model involves IGF-1R binding to IGF-1/2, the following activation of PI3K-Akt-signaling cascades, driving cell proliferation and apoptosis inhibition. Here we report a ...

ObjectiveTo explore the underlying mechanisms of Hrd1/sema3a/IGF-1R on cardiomyocyte apoptosis.

In the present study, the title compound 1,7-bis(4-bromophenyl)heptane-1,7-dione (BBPHD) was synthesized according to the procedure described in literature, and its solid state crystal structure was characterized by the single crystal x-ray diffraction study. The complete crystallographic inform...

Inflammation-mediated disorders are on the rise and hence, there is an urgent need for the design and synthesis of new anti-inflammatory drugs with higher affinity and specificity for their potential targets. The current study presents an effective and new protocol for the synthesis of thienyl-p...

Three triazine-cored organic dyes containing triarylamine donor and cyanoacrylic acid acceptor were synthesized and used as sensitizers in dye-sensitized solar cells. Mono- and dianchoring dyes were designed by varying the number of donor/acceptor arms and conjugation length of the acceptor arm ...

Sulfation and glucuronidation of phenol, 4-nitrophenol (4NP) and N-hydroxy-2-acetyl-aminofluorene (N-OH-AAF) were studied in adult (60 days) male and female rats.Within 3 hours almost 50% of a dose of phenol was excreted in urine as phenyl sulfate; male rats excreted slightly more phenyl sulfate...

The extent of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rat was determined by following changes in histochemistry, and the activities of glutamate-oxaloacetate transaminase (EC 2.6.1.1) and glutamate-pyruvate transaminase (EC 2.6.1.2) in serum. Administration of N-hydroxy-...

Sulfation activity towards N-hydroxy-2-acetylaminofluorene and 4-nitrophenol was determined in male rat liver cytosol at several time points after partial hepatectomy corresponding to G1-, S-, and M-phase. N-hydroxy-2-acetylaminofluorene sulfation activity decreased by 80% when hepatocytes enter...

A novel series of coumarin-1,2,4-oxadiazole hybrids were designed, synthesized, and evaluated as anticonvulsant agents. The title compounds were easily synthesized from reaction of appropriate coumarins and 3-aryl-5-(chloromethyl)-1,2,4-oxadiazole derivatives. In vivo anticonvulsant activity of ...