The study deals with the ‘vanadium (IV) sulfate’ and ‘vanadium (V) pentoxide’ dissolution processes in 3 M H2SO4 aqueous media. Several measurements of the concentration of dissolved VO2+ and VO2+ were achieved in the range of 0–40 °C, and allowed to understand the limitations of the disso...

In this study, a new series of 2-[[α-(4-substitutedbenzoyloxy)-α-phenylacetyl or methylacetyl]amino]-5-(4-methoxyphenyl)-1,3,4-oxadiazoles were obtained by condensation of 2-[(α-chloro-α-phenylacetyl or α-bromopropionyl)amino]-5-(4-methoxyphenyl)-1,3,4-oxadiazoles with sodium salts of 4-sub...

In developing technetium-99m–based radioligands for in vivo studies of cardiac adrenergic neurons, we compared the uptake characteristics of the 99mTc-labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-methylpropylamino)-piperidine (99mTc-FBPBAT) with those of the cl...

Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [η6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT...

Density functional theory is one of the most popular accepted computational quantum mechanical techniques used in the analysis of molecular structure and vibrational spectra. Experimental and theoretical investigations of the molecular structure, electronic and vibrational characteristics of 4-[...

A study was conducted on the optical properties of alkoxy-substituted bisazomethine dyes possessing a dipropylamino terminal group in solution and the solid state. All of the derivatives had similar optical properties in chloroform solution, showing weak fluorescence quantum yield of 5%. In the ...

Background: Rifampicin is a semisynthetic antibiotic derivative of rifamycin used worldwide for the treatment of various forms of tuberculosis.Objective: The objective of this study was to compare, under fasting conditions in healthy volunteers, the rate and extent of absorption of a generic rif...

A simple and rapid isocratic, high performance liquid chromatography (HPLC) assay employing solid phase extraction (SPE) for the simultaneous determination of the anti HIV drug, efavirenz, the anti-tuberculosis drug, rifampicin and the desacetyl metabolite of rifampicin in plasma from HIV/tuberc...

The title compounds of (1R*,3S*) configuration were prepared from 3-formyl-2,2-dimethyl-cyclopropanecarboxylate by addition of CF3CCl2ZnCl, acetylation, and reductive β-elimination with zinc, whereas the (1R*,3R*) isomer was derived from Me2C=CHCH(OH)CCl2CF3 by diazoacetylatlon. Cu(II) catalyze...

A series of new N-(2-(1,1-dimethyl-5,7-dioxo-4,6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives (8a–i) and ethyl 2,2-dimethyl-1-(3-(2-(sulfonamido)ethyl)ureido) cyclopropanecarbox-ylate derivatives (9a–i) were designed, synthesized and evaluated for their anticonvulsant activities u...

Biostimulants improve yield, quality, and stress acclimation in crops. In this work, we tested the possibility of using phenolics-rich extracts from spelt (Triticum dicoccum L.) husks to attenuate the effects of salt stress (100–200 mM NaCl) in maize. Two methanolic extracts were prepared from ...

An investigation of supramolecular synthons of p-hydroxybenzoic acid (PHBA) has been carried out in this work. Three different kinds of compounds derived from PHBA (hydrate (1), co-crystal (2) and salt (3)) have been synthesized and characterized by single-crystal X-ray diffraction, infrared spe...

This paper reports our results in the analysis of polysulphonated anionic dyes and their intermediates using high-performance liquid chromatography–mass spectrometry (HPLC–MS). Negative-ion electrospray ionization is the most suitable ionization technique for the molecular mass determination o...

Molecular weights of dyes and intermediates containing one to four sulphonic acid groups were determined by negative-ion electrospray mass spectrometry. Mass spectra of monosulphonated dyes exhibit an important ion that arises from the loss of a cation from a sulphonic group. Sulphonated dyes fo...

The synthesis of several series of imidazo[2,1-a]isoindol-5-ol derivatives and the results of their evaluation against Plasmodium falciparum are presented and discussed. The effects of electron-withdrawing or-donating substituents on different parts of the molecule, as well as those produced by ...

The identification of metabolites from the pyridylglutarimide 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (PG, Rogletimide) was achieved using liquid chromatography—mass spectrometry with a thermospray interface (LC—TSP—MS). The urinary metabolites include PG N-oxide, the products of 4- and 5-h...

Microbial reduction of ethyl 1-benzyl-3-oxo-piperidine-4-carboxylate by the majority of evaluated microorganisms gave the ethyl cis-(3R,4R)-1-benzyl-3R-hydroxy-piperidine-4R-carboxylate as the major product in high diastereo- and enantioselectivities. The 3R,4R-hydroxy ester was produced in 97.4...

Thioridazine hydrochloride is a drug used in treatment of mental illness that shows side effects. Therefore, it is interesting to study the change of the physico-chemical properties of the drug in different environments to understand the mechanism of action of the drug. Thioridazine can be consi...

ABSTRACTLiterature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing mefloquine hydrochloride as the only active pharmaceutical ingredient (API) are reviewed. The solubility and permeabi...

The vesamicol analogue (±)-trans-2-Hydroxy-3-{4-(3-iodophenyl)piperidyl}-1,2,3,4-tetrahydronaphthalene (3′-IBVM), a potent ligand for the vesicular acetylcholine transporter (VAChT), was evaluated as a potential radiotracer for studying VAChT density in vivo. In radioligand binding experiments...