Coccidioidomycosis is a potentially severe infection caused by dimorphic fungi Coccidioides immitis and Coccidioides posadasii. Although guidelines are well established, refractory disease is a matter of concern in the clinical management of coccidioidomycosis. In the present study three isoniaz...

Bis(triorganostannyl) esters of phenylmaleic acid, citraconic acid, maleic acid, phenylsuccinic acid, methylsuccinic acid and succinic acid, R3SnO2CCR1: CHCO2SnR3 (R  Bu, Ph, Cy; R1  Ph, Me, H) and R3SnO2CCHR1·CH2CO2SnR3 (R  Bu, Ph; R1  Ph and R  Bu, Ph, Cy; R1  Me, H), have been pr...

ObjectiveThe use of low-dose aspirin (acetylsalicylic acid [ASA]) has been suggested to attenuate growth of abdominal aortic aneurysms (AAAs), yet solid clinical evidence of this hypothesis is still missing. This study aimed to investigate whether preadmission ASA use influenced the risk of pres...

Amphiphilic hydrogels are widely reported as systems with great potential for controlled drug release. Nevertheless, the majority of studies make use of functionalization or attachment of drugs to the polymer chains. In this study, we propose a strategy of combining amphiphilic polyurethanes wit...

Dendrimers are synthetic macromolecules with a highly-branched structure and high concentration of surface groups. Among dendrimers, Poly(amidoamine) (PAMAM) has received substantial attention as a novel drug carrier and delivery system. Depending on the generation and type of terminal groups, d...

Studies on pollution due to polyaromatics (PAs) focus on a limited number of commercially available compounds such as US-EPA priority polycyclic aromatic hydrocarbons (EPA-PAHs). Benzene polycarboxylic acid (BPCA) method involves oxidation of condensed aromatic rings (CARs) to a few BPCAs, and t...

Earlier studies from this laboratory demonstrated that benz[a]anthracene (BA), 7-methylbenz[a]anthracene (7-MBA) and 12-methylbenz[a]anthracene (12-MBA) undergo a bio-alkylation substitution reaction in the mesoanthracenic position(s) or L-region leading to the biosynthesis of the potent carcino...

The 1- and 2-positions of 7,12-dimethylbenz[a]anthracene (DMBA) were thought not to be involved in biotransformation to 1,2-epoxide and 1,2-dihydrodiol because of steric hindrance from the 12-methyl group (Biochem. Biophys. Res. Commun. 85: 357–362, 1978). However, we have identified four 2-phe...

SummaryThe formation of dihydrodiols from 7-hydroxymethyl-12-methylbenz[a]anthracene by rat-liver microsomal fractions, by mouse skin in short-term organ culture and by chemical oxidation in an ascorbic acid/ferrous sulphate/ EDTA system has been studied using a combination of thin-layer chromat...

Mammary epithelial cells from 3–4-month-old BALBc virgin mice were cultured inside collagen gels in the following serum-free media: Dulbecco's Modified Eagle's Medium/Ham's F-12 (1:1) supplemented with (A) insulin, bovine serum albumin, epidermal growth factor; (B) insulin, bovin...

Benz[a]anthracene (BA) and the monomethyl meso-anthracenic or L-region derivatives 7-methylbenz[a]anthracene (7-methylBA) and 12-methylbenz[a]anthracene (12-methylBA) underwent a bioalkylation substitution reaction in rat lung ctyosol preparations, fortified with S-adenosyl-l-methionine to form ...

The present study demonstrates the biooxidation of 7,12-dimethylbenz[a]anthracene to the corresponding hydroxyalkyi metabolites, 7-hydroxymethylbenz[a]anthracene, 7-hydroxymethyl-12-methylbenz[a] anthracene, and 7,12-dihydroxymethylbenz[a]anthracene in the dorsal subcutaneous tissue of the rat, ...

The hypothesis was tested that 7-sulfooxymethylbenz[a]anthracene (7-SBA) is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene. In conformity with this hypothesis, 7-SBA was more carcinogenic than 7-HBA in inducing sarcomas at the site of repeated subcutaneous in...

N-Formyl-dl-tryptophylglycine ester was cyclized to form 3,4-dihydro-β-carboline derivative (II) by means of polyphosphate ester (PPE). In contrast with this, N-acylglycyl-tryptamine (IIIa, b) or -dl-tryptophan ester (IIIc) underwent two-fold cyclodehydration to yield 5H-imidazo[1′.5′:1.2]pyr...

The microbial transformation of (2Z,6Z)-farnesol was investigated using the plant pathogenic fungus, Glomerella cingulata as a biocatalyst. Oxidation of the remote double bond and isomerization of the 2,3-double bond gave (2Z,6Z)-3,7,11-trimethyl-2,6-dodecadiene-1,10,11-triol and (2E,6Z)-3,7,11-...

The redox flow battery is a leading candidate to supply society with large-scale energy storage. In the category of aqueous organic redox flow batteries, 9,10-anthraquinone-2,7-disulfonic acid (AQDS) is considered a top-performing molecule and shows ideal electrochemical behavior at low concentr...

This contribution deals with the investigation of greener conditions for the preparation of 2,5-diacetyl-isosorbide from the bio-based substances isosorbide and acetic acid. The influence of solvent, catalyst and reactant ratio on the course of the isosorbide conversion and selectivity to 2,5-di...

A specific liquid chromatography–tandem mass spectrometry (LC-ESI-MS/MS) assay was developed and validated for simultaneous determination of two active metabolites of isosorbide dinitrate (ISDN), namely, isosorbide 2-mononitrate (IS 2-MN) and isosorbide 5-mononitrate (IS 5-MN). A simple protein...

Microalgae are potential raw materials for biofuel applications. In this work, microbial lipids from Choricystis minor var. minor were extracted with conventional solvents in a Soxhlet apparatus and with compressed fluids with or without the use of a co-solvent (ethanol or hexane). Also, the tot...

BackgroundBerberine hydrochloride is one the effective compound among Rhizoma Coptidis, Cortex Phellodendri, and other plants. There are several clinical functions of berberine hydrochloride including anti-inflammation, antitumor and immunoregulatory. However, the anti-inflammatory of berberine ...