A series of new zinc complexes containing the 2,2′-dipyridylamine (dipya) ligand and anions of four benzenepolycarboxylic (BPC) acids, namely phthalic (H2pht), isophthalic (H2ipht), terephthalic (H2tpht) and pyromellitic (H4pyr), have been synthesized by ligand exchange reactions. The complexes...

This work presents the synthesis, structural characterization and biological affinity of the newly synthesized copper(II) complexes with the first antibacterial quinolone drug nalidixic acid (nal) or N–donor ligand 2,2′‑dipyridylamine (bipyam). [Cu(II)(nal)(bipyam)Cl], (2) reveals a distorted ...

A mixed Cd(II) complex {[Cd(FcCOO)2(dpyam)(H2O)][Cd(dpyam)2 (H2O)2]·(ClO4)2·CH3OH} (1) (where FcCOO = ferrocenecarboxylic acid and dpyam = 2,2′-dipyridylamine), has been synthesized and characterized by FT-IR, 1H & 13C NMR, UV–Vis spectroscopy and elemental analysis. The molecular structure ...

C2-symmetric and unsymmetrically substituted 2,2′-dipyridylamines have been synthesized by sequential Buchwald–Hartwig aminations of halo-pyridines. The X-ray crystal structure of a copper dichloride complex bearing a C2-symmetric 2,2′-dipyridylamine reveals details of the binding properties ...

Quantum mechanical calculations on W(CO)4(4,6-diphenyl-2,2′-bipyridine) (1) and on W(CO)4(2,2′-dipyridylamine) (2) were performed with the aim to shed light on the nature of the electrochemical behaviour previously observed under Ar. DFT confirmed the stability of 1 after 1e reduction, showing...

This article presents the synthesis, structure characterization and biological affinity of the copper(II) complex with N-donor ligand, 2,2′-dipyridylamine (bipyam) results in the formation of [Cu(II)(bipyam)2Cl]. In this complex, dipyridylamine ligand coordinate to Cu(II) atom in a bidentate mo...

The reaction of CuCO3·Cu(OH)₂ with three different α-hydroxyacids (H2L′) and the nitrogen donor coligand 2,2′-dipyridylamine (dipyam) has produced five new discrete copper(II) complexes. Two kind of compounds have been isolated: neutral complexes of formula [Cu(H2L′)2(dipyam)] and cationic ...

The molecular structure, vibrational spectra and polarizabilities of Ethyl 4-Dimethylaminobenzoate (EDAB) was investigated by density functional theory employing Becke's three parameter hybrid exchange functional with Lee–Yang–Parr (B3LYP) co-relational functional involving 6-311++G(d,p) ...

The review deals with the pharmaceutically important group of pyrimido[5,4-d]pyrimidines (PPs) and covers the relevant literature published from about 1986 through 2014. A synthetic section describes the formation of PPs from pyrimidines both by cyclization to give a second pyrimidine ring and b...

Inhibiting the interleukin 17 pathway is of interest in a number of autoimmune diseases. Herein, 42 fused pyrimidines have been evaluated as interleukin 17 secretion inhibitors using a phenotypic assay with peripheral blood mononuclear cells. 7H-Pyrrolo [2,3-d]pyrimidin-4-amines having aryl grou...

The first observation of methane photochemical production from an N,N-dimethylamino-substituted arene (DMABA: 4-(N,N-dimethylamino)benzaldehyde) is described. UV irradiation (λ>298 nm) of DMABA isolated in a solid low temperature (10 K) argon matrix was found to lead to major unimolecular fragm...

The utility of BF3-aided lithiation of 4-dimethylaminopyridine (1) with lithium diisopropylamide (LDA) or lithium tetramethylpiperidide (LTMP) in the synthesis of 4-(dimethylaminopyridyl)chalcogenides (Se, Te) has been studied. The lithiation of the in situ generated 4-dimethylaminopyridine-BF3 ...

Optical rectification (OR) of organic 4-N,N-dimethylamino-4′-N′-methyl-stilbazolium tosylate (DAST) single crystal was investigated. The relation between the two tensor elements d33 and d32 of DAST was theoretically derived to be d32 = 2.29d33. In measurements, the amplitude of the OR voltage ...

Diethyl 2,6-dimethyl-4-aryl-4H-pyran-3,5-dicarboxylates (1) have been synthesized by the reaction of aryl aldehyde and 1,3-diketone catalyzed by ZnCl2 under ultrasound irradiation. The effects of changes in the ultrasonic power, temperature, and reaction time are discussed. With the optimized re...

A new methodology has been developed for the synthesis of 3-amino-1H-indole-2-carboxylates. 2-Aminobenzonitriles were protected as benzyl (2-cyanophenyl)carbamates and converted into corresponding glycinate esters using sodium hydride and bromoacetate esters. Sodium hydride efficiently promotes ...

The discovery of a novel series of β-methyltryptophan (β MeTrp) derivatives as selective and orally active non-peptide somatostatin receptor 2 (SSTR2) agonists for the treatment of Type 2 diabetes is described. In our previous research, Compound A, β-MeTrp derivative with highly potent and se...

In this work, a novel ionic liquid based dispersive liquid–liquid microextraction (IL-DLLME) method has been developed for spectrophotometric copper determination in natural waters. The method is based on the extraction of Cu(II) in the form of a complex with 3-dimethylamino rhodanine and deter...

2-Methylaminothiazolines 3 were synthesized selectively from N-(2-hydroxyethyl)-thioureas 2 by the intramolecular Mitsunobu reaction.

A novel compound 1,3-diphenyl-4-(4′-fluoro)benzal-5-pyrazolone N(4)-phenyl semicarbazone (DP4FBP-PSC) has been synthesized. X-ray single crystal structure analysis shows that the compound has interlaced structure linked by intermolecular hydrogen bonds. The results of fluorescence emission spec...

Synthesis of 3-fluoro-5-hydroxy-4- [2-phenyl-(E)-ethenyl]-2 (5H) -furanone as an inhibitor of the phospholipase A2 (PLA2) was described.