Heterocyclic molecules belong to the most attractive group owing to their broad spectrum of antimicrobial activities. In the undertaken research, a number of new 5-substituted-2-((6-chloro-3,4-methylenedioxyphenyl)methylthio)-1,3,4-Oxadiazole derivatives (6a–l) were synthesized by converting va...

A new series of 4-amino-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines (2a–m) bearing the 2-chloro-2-phenylethyl chain at the N1 position, has been synthesized. The affinity of these compounds for A1 adenosine receptor (A1AR) was measured. The compounds showed poor affinity. A more interesting resu...

Lithiation of chloroferrocene (1a) with n-butyl lithium or lithium tetramethylpiperidinide (LiTMP) followed by addition of dimethyldisulfide gives 1-chloro-2-methylthioferrocene (2). Renewed treatment of 2 with LiTMP and MeSSMe yields 1-chloro-2,5-bis(methylthio)ferrocene (3), the structure of w...

We demonstrate that a proapoptotic chemical agent, oxidopamine, induces dose dependent changes in chromatin textural patterns which can be quantified using the Gray level co-occurrence matrix (GLCM) method. Peripheral blood (heparin-pretreated) samples were treated with oxidopamine (6-OHDA, 6-hy...

Isopropyl phenyl ketoxime reacts with acetylene in the KOH/DMSO suspension (atmospheric pressure, 90 °C, 4 h) to afford 3,3-dimethyl-2-phenyl-3H-pyrrole (30%) and 4,4-dimethyl-5-phenyl-1-vinyl-2-pyrrolidinone (5%) that is likely originated from 4,4-dimethyl-5-phenyl-3,4-dihydro-2H-pyrrol-2-ol a...

Reaction between isopropyl phenyl ketoxime and acetylene in the KOH–DMSO–n-hexane system (70 °C, ∼ 5 min), along with known 3,3-dimethyl-2-phenyl-3H-pyrrole (51% yield) and 4,4-dimethyl-5-phenyl-1-vinyl-2-pyrrolidinone (7% yield), affords also unexpected 2-(2-ethynyl-3,3-dimethyl-2-phenyl-1-...

A series of pyrrolidinones have been reported to possess hypoli-pidemic activity in mice. The most active agent, 4-phenyl-5-5-dicarbethoxy-2-pyrrolidinone, effectively lowered both serum cholesterol and triglyceride levels at 20–30 mg/kg/d. The agent suppressed liver mitochondrial citrate excha...

Recently, nanomaterial-based artificial enzymes have expected abundant consideration because of cheap, accessibility, and respectable stability. In this study, we report a Th-MOF artificial peroxidase, which can oxidize 3,3,5,5-tetramethylbenzidine by hydrogen peroxide to yield a blue product. T...

The process of association between 5,10,15,20-tetrakis[4-(trimethylammonio)phenyl]-21H,23H-porphine tetra-p-tosylate (H2TTMePP) and uric acid as well as its sodium salt has been studied in aqueous NaOH solution analysing its absorption and steady-state fluorescence spectra. The fluorescence quen...

BackgroundCirculating uric acid (UA) is an important biomarker, not only in the detection and management of gout, but also in assessing the risk of related comorbidity. The impact of collection methods on clinical UA measurements has been the subject of limited study. After observing significant...

Reducing uric acid is hypothesized to lower blood pressure, although evidence is inconsistent. In this ancillary of the DASH-Sodium trial, we examined whether sodium-induced changes in serum uric acid (SUA) were associated with changes in blood pressure. One hundred and three adults with prestag...

The mechanism underlying the reduction in uric acid levels in hyperuricemia rats by caffeic acid was investigated in this study. Different doses of caffeic acid (25, 50, and 100 mg/kg) were administered to hyperuricemia rats induced by the intraperitoneal injection of potassium oxonate. In vivo ...

A series of novel analogs of pyrrole alkaloid were designed and synthesized by a facile method and their structures were characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry (HRMS). The structure of compound 2a was identified by 2D NMR including heteronuclear multiple-quantum c...

Ester-, cyano-, and carboxamide-substituted 1H-pyrroles undergo electrophilic aromatic bromination, if treated with hydrogen peroxide and sodium bromide at pH 6.2 and 20 °C. Oxidation of bromide under such conditions is catalyzed by a vanadate(V)-dependent bromoperoxidase, in a substrate/enzyme...

The mononuclear complexes (Bu4N)[Mn(Cl4Cat)2(H2O)(EtOH)] and (Bu4N)2[Mn(Cl4Cat)3] (H2Cat=1,2-dihydroxybenzene) have been synthesised and characterised by X-ray diffraction. This work provides a direct, independent, synthesis of these complexes and an interesting example of how solvent effects ca...

About 100 different purine derivatives and analogs were tested for their effect on protein synthesis and protein degradation in isolated rat hepatocytes. These included 6-aminopurines (adenine and adenosine analogs), 6-mercaptopurines, chloropurines, oxypurines, cytokinins, methylxanthines, meth...

A molecularly imprinted polymer (MIP) was designed and synthesized to serve as a functional material for selective recognition of 6-thioguanine (6TG), an antitumor drug. For that, the newly synthesized functional monomer, cytosine-bis(2,2′-bithienyl)-(4-carboxyphenyl)methane ester (Cyt-S4), rev...

The electrochemical oxidation of 9-methylxanthine proceeds via four voltammetric oxidation peaks at the pyrolytic graphite electrode. The first voltammetric oxidation peak (peak Ia) is a 1e reaction giving a radical which dimerizes to 8,8′-bi-9-methyl-9H-purine-2,6-(1H, 3H)-dione. Peak IIa is a...

Synthetic methods for the preparation of the heterocyclic ligand 2-pyridylmethylene-1-amino-2-naphthol (PMAN) and its complexes with copper(II), nickel(II) and cobalt(III) are described. The structure of the ligand and of its metal complexes has been investigated by IR, UV/VIS and mass spectrosc...

A hypercrosslinked poly(styrene-co-divinylbenzene) resin (TEPA) was synthesized and characterized as a specific polymeric adsorbent for concentrating berberine hydrochloride from aqueous solutions. Three organic molecules of different sizes (2-naphthol, berberine hydrochloride, and Congo red) we...