The electrochemical behaviors of a tris(2-pyridylmethyl)amine copper complex (Cu-tmpa) in aqueous buffer solutions were examined. Acid-base and redox equilibria were clarified using cyclic voltammetry and ESR spectra. The pKa values of both CuII-tmpa and CuI-tmpa were determined based on the pH-...

Four new structures of CdII complexes containing bis(2-pyridylmethyl)amine (bispicam) ligands have been determined. Chloride anions bridge two CdII ions to form a dinuclear complex [(Cd(bispicam)Cl)2(μ2-Cl2)] (1), and bromide and iodide ions produce two halide-coordinated [Cd(bispicam)X2] compl...

Two porphyrinato-zinc derivatives modified with two and four N,N-di(2-pyridylmethyl)amino groups, namely Zn-Porphyrin-2-DPA (1) and Zn-Porphyrin-4-DPA (2), have been designed, synthesized, and characterized. Systemic studies over a series of metal ions reveal that binding with Fe3+ for the forme...

Attachment of N,N-bis(2-pyridylmethyl)amine (L1) and N-(2-pyridylmethyl)glycine (L2) ligands on the azide-functionalized SBA-15 type mesoporous silica support and subsequent insertion of metal salts into the ligand-immobilized supports yielded heterogeneous metal complex catalysts, M(A)/SBA*-Ln-...

A copper(II) complex of (R)-N-(2-pyridylmethyl)pipecolate (pmpi) was prepared, and its structure was revealed by X-ray crystal structure analysis. Mixed ligand complexes were then prepared from this complex and (R)- and (S)-N-(t-butoxycarbonyl)leucinate (BocLeu). The (R)-BocLeu complex is less s...

We have synthesized the fully unsymmetrical [(6-bromo 2-pyridylmethyl) (6-fluoro 2-pyridylmethyl) (2-pyridylmethyl)] amine tripod FBrTPA. The synthesis involves preparation of the already known [(6-bromo 2-pyridylmethyl) (2-pyridylmethyl)] amine BrDPA, which is obtained either by classical conde...

Monoaza-dithia- (1a – 3a) and diaza-tetrathia- (1b and 3b) macrocycles with a pendant 2-pyridylmethyl fragment have been prepared by the reaction between 2-(aminomethyl)pyridine with dibromide-dithioether derivatives. Four of the macrocycles have been characterized by X-ray crystallography, rev...

2-Acetoxymethylpyridine (I) and 2-, 3-, and 4-acetoxymethylpyridinium methiodides (II, III, and IV, respectively) are spectrophotometrically useful substrates for acetylcholinesterase. Compounds III and IV are highly water soluble yet equal to phenyl acetate in resistance toward aqueous hydrolys...

The reactions of 2- and 4-picoline N-oxides with acetic anhydride uniformly labelled with 18O have been studied in three different solvents and the products subjectd to 18O analyses.With 2-picoline N-oxide, the change of solvent did not effect the 18O distribution of the resulting main product, ...

Desethyl-atrazine (DEA) and desisopropyl-atrazine (DIA) are the two major degradation by-products of atrazine (a suspected human carcinogen and endocrine disrupting herbicide), and show an equal toxicity to their parent compound. This study investigated the degradation of DEA and DIA with OH and...

The partial rate factors for the sulfonation of neopentylbenzene in 89·9% H2SO4 at 25·0° were determined to be fp = 82 ± 12, fm = 5·7 ± 1·4 and fo = 1·2 ± 0·6. The low fo/fp ratio is ascribed to steric hindrance for ortho-substitution. Evidence for the non-bonded interaction of a neope...

A series of neopentylbenzene derivatives with substituents in 2- and 6-positions has been synthesized. A number of compounds were investigated by dynamic NMR spectroscopy. Restricted rotation was observed in 3-methyl-2-neopentylbenzoic acid and its derivatives. Thermodynamic and Arrhenius parame...

In the present research, the temperature dependence of heat capacity Cp,m∘=f(T) of neopentylbenzene C6H5–C5H11 has been measured between T = (6 and 350) K in the precision adiabatic vacuum calorimeter and reported for the first time. The temperature and enthalpy of fusion of neopentylbenzene a...

Chromone-3-carboxamides react with cyanothioacetamide in the presence of NaOEt in boiling ethanol to form 5-oxo-2-thioxo-1,5-dihydro-2H-chromeno[4,3-b]pyridine-3-carbonitriles (67–87% yields), whereas their reaction with N-methylcyanothioacetamide and a catalytic amount of Et3N in boiling ethan...

Photooxidation of alcohols without organic solvents in the presence of O2 took place at the atmospheric pressure and room temperature over Nb2O5 and Cu/Nb2O5, avoiding the cost, toxicity, and purification problems associated with transition-metal systems. Loading of a small amount of copper on N...

We successfully prepared Pd-containing perovskite strontium titanate (Pd-STO) by a relatively low-temperature hydrothermal method (i.e., 373 K) without posterior calcination. The particle size and porosity of the STO perovskite could be tuned by changing the molar ratio of H2O/NH3 (e.g., 5.0, 12...

Alzheimer's disease (AD) is an age-related disease characterized by loss of memory and disrupted thinking that is associated with altered energy metabolism. Variants of an important enzyme of energy metabolism, dihydrolipoamide dehydrogenase (dld), have been genetically linked to late-onset...

The objective of this study was to investigate a possible role of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as a chemical preconditioning target for neuroprotection against ischemic injury. We used 5-methoxyindole-2-carboxylic acid (MICA), a reportedly reversible DLDH inhibitor, as the...

In this article, a brief conformational and spectroscopic characterization of 5-methoxyindole-2-carboxylic acid (5-MeOICA) via experimental techniques and applications of quantum chemical methods is presented. The conformational analysis of the studied molecule was determined theoretically using...

Two new complexes of Cd(II) with an O-deprotonated anion of 5-methoxyindole-2-carboxylic acid (5-MeOI2CA), of the formulas [Cd(5-MeOI2CA)2(H2O)2]n (1) and [Cd3(5-MeOI2CA)6(H2O)4(DMSO)4]⋅2DMSO (2) were synthesized. In the polymeric complex 1, the 5-MeOI2CA anion acts as a bidentate bridging ligan...