The reaction of Ir4(CO)12 with t-BuNC or MeNC in the presence of trimethylamine oxide in refluxing tetrahydrofuran provides the substituted iridium clusters Ir4(CO)12-x(RNC)x] (χ  14; R  t-Bu, Me). The infrared and 13C NMR spectra of these molecules indicate that most of them adopt struct...

4,4′-Bis(chloroacetyl)diphenylether was synthesized and its polycrystal form was produced. This polycrystal sample was irradiated by gamma rays (60Co) for 72 h. The ESR method was used to observe formation of free radical on the sample. ESR signal was not recorded from the non-irradiated sample...

The hemocyanin of Oncomelania hupensis (OhH) is essential for the survival of O. hupensis and may be an effective target for the development of new molluscicide. 4-(Chloroacetyl)catechol is a substrate analogue of OhH. In this study, we evaluated the toxicity of 4-(chloroacetyl)catechol to O. hu...

A gas chromatographic procedure has been developed for the trace determination of chloroacetyl chloride (CAC) and two of its impurities: methyl chloroacetate (MCA) and chloroacetic acid (CAA). All three compounds are derivatized using piperidine in dichloroethane prior to their analysis via gas ...

The aim of this study was to observe the possible function of increased superoxide and NO production in the response of barley root tip to the harmful level of Cd. While superoxide generation was detected only in the transition zone, the formation of NO was observed in the apical elongation zone...

Endoplasmic reticulum (ER) homeostasis is essential for cell function. Increasing evidence indicates that, efficient protein ER export is important for ER homeostasis. However, the consequence of impaired ER export remains largely unknown. Herein, we found that defective ER protein transport cau...

The number of people with diabetes is estimated to be over 370 million, in 2030 it will increase to 552 million. In Poland, the number of people with diabetes is estimated to be 3.5 million (9.1%). According to the estimates of the International Diabetes Federation, the percentage of patients in...

Cryopreservation of sperms is common therapy but with multiple damages to sperms. The aim of this study was to assess the effect of insulin as a prosurvival factor on the most important functional parameters of human spermatozoa during cryopreservation. Semen samples were obtained from 15 normoz...

Direct qualitative methods that allow the rapid screening and identification of insulin products during early stages of the drug development process and those already in the market can be of great utility for manufacturers and regulatory agencies and the recent scientific literature describes se...

A new experimental technique with a rotating analyzer is applied to polarization measurements of luminescence spectra. This method enables us to record the difference of the vertical and the horizontal polarization components (Iv-Ih) with a high sensitivity. The sum (Iv+Ih) and the individual co...

A benzoperylene probe excimer emission in an aqueous buffer solution is observed for the first time, and a novel ratiometric fluorescence method based on the probe excimer emission for the sensitive detection of heparin and heparinase is demonstrated. A negatively charged benzoperylene derivativ...

A ratiometric nanosensor for the selective detection and intracellular imaging of highly reactive oxygen species (hROS) is developed. Benzoperylene probe and Mn-ZnS quantum dots based nanoparticles were fabricated through cost effective and simple procedures. The nanoparticles exhibit distinct e...

Bleomycin (BLM) is used clinically in combination with a number of other agents for the treatment of several types of tumours. Members of the BLM family of drugs include zorbamycin (ZBM), phleomycin D1, BLM A2 and BLM B2. By manipulating the BLM biosynthetic machinery, we have produced two new B...

Scopafungin (U-29479), an antibiotic produced by a streptomycete strain, acts as an uncoupling agent of oxidative phosphorylation in mitochondria. In addition, mitochondrial respiration is also impaired but to a lesser degree. Studies of individual reaction sequences occurring within the respira...

Publisher SummaryThis chapter discusses the cytotoxic and antitumor antibiotics produced by microorganisms. Microorganisms are among the most prolific producers of new biologically active compounds. Many antibiotics are able to suppress or retard the growth of tumors; an extensive effort has bee...

A facile synthesis of 4-amino-N-benzylbenzo[b][1,8]naphthyridin-2(1H)-ones 3 is described from N-benzyl-N-(3-cyanoquinolin-2-yl)acetamides 2 with t-BuOK in excellent yields in mild conditions. These reactions proceeded at room temperature under aerobic atmosphere in very short period. The cycliz...

A synthetic method of 3-substituted 2-quinolinones from readily available α-substituted N-[(E)-stilben-2-yl]acetamides have been developed. α-Carbonylalkyl radical, produced by the manganese(III) acetate oxidation of N-[(E)-stilben-2-yl]acetamides, undergoes an intramolecular 6-exo-dig cycliza...

Novel N-substituted 2-(diphenylthiophosphoryl)acetamides ligands containing pyridine and quinoline fragments, were synthesized and studied as extractants for Pd(II) ions from HCl solutions. The introduction of a pyridine and a quinoline fragments into 2-diphenylthiophosphorylacetamide molecule r...

1,3-dipolar cycloaddition of diaryldiazomethanes Ar2CN2 across Cl3C–CHN–CO2Et 1 yields Δ3-1,2,4-triazolines 2. Thermolysis of 2 leads, via transient azomethine ylides 3, to diaryldichloroazabutadienes [Ar(Ar')CN–CHCCl2] 4. Treatment of 4a (Ar = Ar' = C6H5) and 4c (Ar = Ar' = p...

(OC-6-33)-Dichlorido(ethane-1,2-diamine)dihydroxidoplatinum(IV) (1) was carboxylated using succinic- or 3-methylglutaric anhydride. The resulting bis(carboxylato)platinum(IV) complexes display free, uncoordinated carboxylic acid groups which were further derivatized with primary aliphatic alcoho...