The work involves the vibrational spectral analysis of 2.6 bis (tri fluro methyl) benzoic acid using FT-IR and FT-Raman spectroscopy. The computations were performed at DFT level of theory to get the optimized geometry and vibrational wave numbers of the normal modes of the title compound using ...

A series of chiral pyridazin-3(2H)-ones was synthesized, separated as pure enantiomers, and evaluated for N-formyl peptide receptor (FPR) agonist activity. Characterization of the purified enantiomers using combined chiral HPLC and chiroptical studies (circular dichroism, allowed unambiguous ass...

Aminopeptidase N (APN) has been proved to be deeply associated with cancer angiogenesis, metastasis and invasion. Therefore, APN gains increasing attention as a promising anti-tumor target. In the current study, we report the design, synthesis, biological evaluation and structure-activity relati...

Kinesin Spindle Protein (KSP) or Eg5 is an essential kinesin that is involved in spindle separation process during mitosis and also unregulated in certain cancer cells. Inhibitors of this enzyme have proved to be effective to block spindle separation followed by mitotic arrest and apoptosis of t...

S-(−)-1-phenyl ethyl ammonium(1+) sulphate and S-(−)-1-phenyl ethyl ammonium(1+) hydrogen phosphate 2.5 hydrate were prepared at laboratory temperature by slow evaporation of aqueous solutions of a mixture of S-(−)-1-phenyl ethyl amine and H2SO4 or H3PO4 in a molar ratio of 2: 1. The chirality o...

A multicomponent reaction between ethyl 3-aminocrotonate, phenyl isothiocyanates, 2,2-dichloroacetyl chloride and to give 6-thioxo-1,6-dihydropyrimidine-5-carboxylate. This one-pot, three-component condensation took place under mild conditions in THF/CH3CN at 50 °C. The crystal structure of the...

An efficient palladium-catalyzed Suzuki–Miyaura cross-coupling protocol effected in a mixture of DME/water (2:1) enables the reaction of sterically hindered and electron rich 6-chloro or 6-bromo-1,4-benzoxazines(ones) with a variety of aryl, vinyl or alkylboronic acids. Coupling is effected wit...

Gram-scale total synthesis of (±)-8-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]-galangin (1) and -chrysin (2) has been accomplished in eight steps from commercially available phloroglucinol and three steps from commercially available chrysin, respectively, featuring an efficient introduct...

In this work, the luminescence of a novel Terbium-[Ethyl-4-hydroxy-1-(4-methoxyphenyl)−2-quinolinone-3-carboxylate] complex has been investigated as an analytical probe for pesticide detection. The sensitivity of Tb(III):L1 probe fluorescence in molar ratio 1:1 across eight pesticides was assaye...

Novel polyalkoxy-3-(4-methoxyphenyl)coumarins – analogues of natural antimitotic compounds – were synthesized from plant allylpolyalkoxybenzenes and tested in vivo in the phenotypic sea urchin embryo assay for antiproliferative antitubulin activity.

The first asymmetric cyclopropanation of ketene silyl acetal with allylic acetate was achieved. New chiral oxazolidinylpyrazole ligands and their η3-allylpalladium complexes were synthesized. Reaction of cinnamyl acetate with ketene silyl acetal of ethyl isobutylate in the presence of a palladi...

An eco-benign and highly efficient route for N-acylation of amines has been developed by treating amines with corresponding carboxylic acids in the presence of 2 mol % of heteropolyanion-based ionic liquids as catalysts under solvent-free conditions. This practical reaction could tolerate a wide...

The voltage-sensing domain (VSD) is a conserved structural module that regulates the gating of voltage-dependent ion channels in response to a change in membrane potential. Although structures of many VSD containing ion channels are now available, our understanding of the structural dynamics ass...

Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactiva...

Conorfamides (CNFs) are toxins initially characterized from the venom duct of the venomous marine snail Conus spurius from the Gulf of Mexico; at their C-termini, these toxins are amidated and have high sequence similarity with the molluskan cardioexcitatory tetrapeptide Phe-Met-Arg-Phe-NH2 (FMR...

In this study a new set of thiazolo[5,4-d]pyrimidine derivatives was synthesized. These derivatives bear different substituents at positions 2 and 5 of the thiazolopyrimidine core while maintaining a free amino group at position-7. The new compounds were tested for their affinity and potency at ...

An unexpected ring-contraction from benzo[b]pyrazino[1,2-d][1,4]thiazine-1,4-diones (6) to benzo[4,5]thiazolo[3,2-a]pyrazine-1,4-diones (7) has been developed. The preliminary mechanistic studies showed the transformation contained two independent steps: the first step is the formation of a Mich...

A diverse library of 1-phenyl-pyrazole-4-carboxylic acid derivatives were synthesized and evaluated for their inhibitory potency against xanthine oxidoreductase (XOR) in vitro and vivo, and the structure-activity relationship (SAR) analyses were also presented. Approximately half of the target c...

Here we report two mononuclear Co(II) and Ni(II) complexes of general formula [M(L)2(H2O)].2H2O; {M = CoII & NiII} derived from bidentate 2-chloro-6-{[(4-hydroxy-3-methoxyphenyl)methylidene]amino}-4 nitrophenol ligand (HL). These compounds were characterized by elemental analysis, spectral (FT-I...

N-(Chloro-3-methoxyphenyl)-2-picolinamide (3, ML128, VU0361737) is an mGlu4 positive allosteric modulator (PAM), which is potent and centrally penetrating. 3 is also the first mGlu4 PAM to show efficacy in a preclinical Parkinson disease model upon systemic dosing. As a noninvasive medical imagi...