Overexpression of P-glycoprotein (P-gp) is one of the major obstacles to successful cancer chemotherapy. In this study, we examined the ability of 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide (C-4) to reverse multidrug resistance (MDR) in P-gp expressing KBV20C cells...

The fluorescence in dilute solution has been measured for five polyesters with terephthalate as the rigid aromatic unit and diols derived from cyclohexane as the flexible spacer. The spacers are 1,2-cis-cyclohexanediol, 1,2-trans-cyclohexanediol, a 1:2 mixture of 1,3-cis- and 1,3-trans-cyclohexa...

A 1:1 complex between copper(II) chloride and cis-1,3-cyclohexanediol has been synthesized and its crystal structure determined. The structure is composed of two different dinuclear [CuCl2(c-13chd)]2 units in which the copper(II) ions are surrounded by the two oxygen atoms of the diol and the tw...

Combining three bioactive units, such as 2(5H)-furanone, 1,2,3-triazole, and amino acid together into one potential drug molecule with polyfunctional groups, a series of new chiral 2(5H)-furanone derivatives containing 1,2,3-triazole moiety have been designed and synthesized from (5S)-5-alkoxy-3...

The inhibition of protein–protein interactions remains a challenge for traditional small molecule drug discovery. Here we describe the use of DNA-encoded library technology for the discovery of small molecules that are potent inhibitors of the interaction between lymphocyte function-associated ...

The electrochemical reduction of uranyl ions in calcium nitrate tetrahydrate has been studied by polarography, cyclic voltammetry, chronopotentiometry and the potential-step techniques. The UO2+2/UO+2 couple, reversible in the aqueous system, is complicated by disproportionation of UO+2 and by f...

Self-healing concrete through microencapsulated calcium nitrate was evaluated for its crack-sealing efficiency. The evaluated variables in this study were the microcapsule size, concentration (by weight of cement), and capsule shell properties. The production parameters for the microcapsule prep...

Basal media including Murashige and Skoog (MS), Woody Plant Medium (WPM), and Driver and Kuniyuki (DKW) media were compared for use in guayule regeneration and propagation. Explants grown on MS basal medium showed large size calli with multiple shoots, but the calli produced on DKW medium were o...

The titled new azo-compound namely, 7-((1H-benzo [d]imidazol-2-yl) diazenyl)-5-nitroquinolin-8-ol, and its Cr(III), Mn(II), Co(II), Ni(II) and Cu(II) complexes have been designed and prepared. These compounds were characterized by spectral and analytical techniques. The IR spectral data suggeste...

RésuméUne série de triazine-1,2,3 ones-4 a été synthétisée et étudiée pour son activité anti-dépressive potentielle comparativement à la trazodone 2. Plusieurs de ces composés ont manifesté une potentialisation des effets centraux de l'hydroxy-5 tryptophane (5-HTP) supérieure...

Developed herein is a diversity-oriented one-pot multicomponent synthesis of polycyclic 3,3′- pyrrolidinyl-dispirooxindoles 3 via a multicomponent 1,3-dipolar cycloaddition event of 3-methyl-4-nitro-5-isatylidenyl-isoxazoles 2 with azomethine ylides (thermally generated in situ from isatins and...

A combination of fluorophore and nucleobase through a π-conjugated rigid linker integrates the base pairing and the fluorescence change into a single event. Such base discriminating fluorophore can change its fluorescence as a direct response to the base pairing event and therefore have advanta...

Complete asymmetric induction has been achieved during Grignard alkylations/arylations resulting in (1S,2R)- and (1R,2R)-1-phenyl-1-alkyl/aryl-2-(1-pyrrolidinyl)-1-propanols which are isolated as hydrochlorides.

FT-IR and Raman spectra together with the vibrational spectral assignments between 4000 and 400 cm−1 of 4-(1-Pyrrolidinyl)piperidine (4-pypp) have been reported. The optimized structural parameters (bond lengths, bond and dihedral angles), normal mode frequencies and corresponding vibrational as...

Herein, we report the first access to diethyl glycosamine-1-difluoromethylphosphate as phosphate mimic. The diethyl 2-nitro-glycosides-β-1-difluoromethylphosphonate were obtained from a Michael addition of diethyl(difluoro-(trimethylsilyl)methyl)phosphonate on 2-nitroglycals in the presence of ...

This study aims to establish a cellulose pretreatment process using ionic liquids (ILs) for efficient enzymatic hydrolysis. The IL 1-ethyl-3-methyl imidazolium diethyl phosphate ([EMIM]DEP) was selected in view of its low viscous and the potential of accelerating enzymatic hydrolysis, and it cou...

Chitosan/alginate nanoparticles (CANPs) were formulated to encapsulate curcumin diethyl diglutarate (CDG) for oral delivery. CDG-loaded CANPs (CDG-CANPs) were prepared by o/w emulsification and ionotropic gelation. The optimization of CDG-CANPs was successfully performed by response surface meth...

A novel plasticizer, epoxidized cardanol diethyl phosphate (ECEP), based on cardanol was synthesized. Chemical structure of ECEP was characterized by fourier transform infrared (FTIR), 1H -nuclear magnetic resonance(1H NMR) and 13C -nuclear magnetic resonance(13C NMR). Effects of ECEP substituti...

Allyl diethyl phosphate (ADP) was found to function as a stoichiometric hydrogen acceptor in a catalytic oxidation reaction of alcohols with Pd(OAc)2. A variety of acyclic primary and secondary alcohols were oxidized in good yields and under mild conditions to the corresponding aldehydes and ket...

Long term exposure to organophosphate pesticides can be evaluated by quantitative analysis of their non-specific metabolites in hair matrix. The aim of this study was to determine whether these metabolites can be internally incorporated into the hair of rabbits exposed to diazinon and chlorpyrif...