A new series of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazoles were synthesized and their cytotoxic activities in vitro against four different cell lines (HT-29, MCF-7, NIH-3T3, AGS) were evaluated. Compound 6g bearing 3,4,5-trimethoxyphenyl moiety on ring A and 4-methoxy substituen...

The novel 7-hydroxy-3-(3,4,5-trimethoxyphenyl)coumarin (1) has been synthesized via Perkin reaction and its phthalonitrile derivatives (2, 3, 4 and 5) have also been prepared from the reaction of this coumarin (1) with 3-nitrophthalonitrile, 4-nitrophthalonitrile or 4,5-dichlorophthalonitrile co...

Human immunodeficiency virus-1 (HIV-1) glycoprotein 120 (gp120) is one of the key targets for treatment of acquired immunodeficiency syndrome. A large number of inhibitors are being designed for this target in order to find safe and effective drugs. In the present study, quantitative structure a...

This work studies the potential of using the tertiary amines 3-dimethylamino-1-propanol (3DMA1P), 3-diethylamino-1-propanol (3DEA1P) and 1-(2-hydroxyethyl)pyrrolidine (1-(2HE)PRLD) as an alternative to 2-(diethylamino)ethanol (DEEA) in the blend with 3-(methylamino)propylamine (MAPA). Vapour pre...

Electronic absorption spectra of 2-(N-methylamino)-3-methyl-4-nitropyridine (M3M4NP), 2-(N-methylamino)-5-methyl-4-nitropyridine (M5M4NP), 2-(N-methylamino)-3-methyl-5-nitropyridine (M3M5NP) and 2-(N-methylamino)-5-methyl-3-nitropyridine (M5M3NP) in the ethyl alcohol, acetonitrile and n-heptane ...

We report the synthesis, binding properties and intrinsic activity at MT1 and MT2 melatonin receptors of new dimeric melatonin receptor ligands in which two units of the monomeric agonist N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide (1) are linked together through different anchor points. ...

AimsDietary related quality of life has not been previously explored with patients with type 2 diabetes using SGLT-2 inhibitors, the latest class of diabetes medications. The study sought to describe the patient experience on SGLT-2 inhibitors and examine if there are improvements in dietary per...

A density functional study of the [2 + 2] cycloaddition between methyleneindolinones and enals catalyzed by prolinol derivatives is presented here. The calculations show that dienamines could be generated under acid-free conditions, and the hydroxyl of the catalysts plays a key role in the forma...

This study evaluates the developmental toxicity of two dialkyl phthalate esters, di-n-heptyl phthalate (DHPP) and di-n-octyl (DnOP) phthalate, which have straight-alkyl side chains of seven and eight carbons, respectively. Sprague-Dawley rats were administered 0, 0.25, 0.50, or 1 g/kg/day of DHP...

The adsorption of heptyl xanthate on germanium has been studied by the attenuated total reflection (ATR) technique. Polarized infrared light was used in situ to determine the average orientation of the alkyl chain in heptyl xanthate adsorbed at the germanium/solution interface. Spectra reveal th...

Adsorption of n-heptyl xanthate on synthesized zinc sulfide was followed in situ by monitoring the methylene absorption band at 2925 cm−1. The zinc sulfide surface used in the adsorption experiments was synthesized on a germanium internal reflection element using the chemical bath deposition met...

A novel chelating surfactant 5-heptyl-1,2,4-triazole-3-thione (HpTT) was synthesized and originally introduced as a collector for flotation separation of malachite from quartz and calcite. Micro-flotation results showed that HpTT exhibited better flotation selectivity for malachite against calci...

A lead sulphide film precipitated on a zinc sulphide layer of an ATR crystal has been used to study in situ surface reactions of heptyl xanthate adsorption. The lead sulphide film was made by the chemical bath deposition method and was analyzed by X-ray photoelectron spectroscopy. In turn deposi...

In this article, 5-heptyl-1,3,4-oxadiazole-2-thione (HpODT) surfactant was synthesized and originally recommended as a collector for flotation recovery of chalcopyrite, bornite and pyrite. The micro-flotation findings indicated that compared with traditional collectors such as sodium isobutyl xa...

Indomethacin (Indo) and naproxen (Nap) belong to Biopharmaceutical Classification System (BCS) class II drugs, which permeate membranes well but are poorly soluble. Two pharmaceutical salts hydrate of Indo and Nap with (1R,2R)-1,2-diphenylethylenediamine (DPEN) were obtained using solution cryst...

3E)exergy/exergoeconomic/exergoenvironmental) analysis is considered to evaluate a novel hydrogen liquefaction process. The proposed process is a simple Claude cycle combined with two absorption refrigeration systems (ARSs). The mass flow rate of the liquid hydrogen LH2 production is about 260 t...

In this study, photovoltaic/thermal (PVT) panels are employed as a roof of the solar chimney power plants (SCPP), to enhance the power generation and exergy efficiency. A parametric study is conducted to scrutinize the influence of the effective parameters on the performance and energy/exergy/ex...

Semaphorin 3E (SEMA3E) has emerged as an axon-guiding molecule that regulates various biological processes including the immune responses and apoptosis. However, its role in the pathophysiology of colitis remains elusive. We investigated the role of SEMA3E in intestinal epithelial cells (IECs) a...

Energetic, environmental and economic (3E) performances are major effective criteria that one needs to consider when designing and optimizing a desalination plant. In order to optimize all the three variables, it is important to determine an optimal system configuration and operation strategy at...

Achieving the goals of emissions intensity reduction and energy mix transition along with steady economic growth is a hot topic in China. This paper constructs an economic growth model under emissions reduction control. Using the PLS regression technique, the potential economic growth rates are ...