The effect of the properties of sulfur and oxygen atoms and of the presence/absence of the BF2 group on the collision induced dissociation (CID) behavior of singly charged ions generated by electrospray ionization (ESI) of N-(pyridin-2-yl)-substituted benzo(thio)amides and N-(isoquinolin-1-yl)fu...

A new series of 2,5 and 1,5-regioisomers of the tetrazolyl group viz., 3-[(5-benzyl/benzylthio-2H-tetrazol-2-yl) methyl]-2-chloro-6-substituted quinoline 6h-q and 3-[(5-benzyl/benzylthio-1H-tetrazol-1-yl) methyl]-2-chloro-6-substituted quinolines 7h-q were synthesized. Docking studies of all the...

We report the discovery of a novel series of 2-(3-alkoxy-1-azetidinyl) quinolines as potent and selective PDE10A inhibitors. Structure–activity studies improved the solubility (pH 7.4) and maintained high PDE10A activity compared to initial lead compound 3, with select compounds demonstrating g...

A peptide, designated thymone A, was isolated from bovine thymus by a sequence of eight procedures prior to micromanipulation. Trypsin destroyed the activity indicating the absence of a non-peptidic but active component. The peptide showed essentially single spots under three conditions of elect...

A peptide, thymone B, was isolated from bovine thymus by sequences of solvent extractions, gel filtrations, ion exchange chromatography and micromanipulation. Paucity of sample restricted all assays. Thymone B showed essentially single spots by TLC in 3 systems and by electrophoresis in one syst...

A fraction, isolated from bovine thymus by sequences of ca. ten steps of extractions, gel filtrations, ion exchange chromatography, etc., stimulated the synthesis of both cAMP and cGMP at a level of 100 μg/ml. Thymone A stimulated cAMP, but is chromatographically remote from the fraction. Essen...

Heavy metals pollution becomes a serious environmental problem because heavy metals are nonbiodegradable and some heavy metal ion such as nickel isknown as toxic metal. In this study, we investigated the natural sorbent materials for removing heavy metals nickel-ions in the wastewaters using car...

Nickel-rich metal oxide layered cathode is the most potential material for high specific capacity Li-ion battery. However, the unstable cycle performance and undesirable rate capacity limit its further application. Herein, we propose a methodology of using nanoflakes assembled flower-like Ni(OH)...

Crystals with fluorite type structure doped with transition metals (TM) in different oxidation states provide the possibility of investigating optical spectra, magnetic properties and ligand field (LF) parameters of TM in cubic eightfold coordination. If the doped ion in the host crystal matrix ...

Two novel acridine-based fluorescence chemosensors (L1 and L2) were prepared and their metal ions sensing properties were investigated. L1 (L2) exhibited an excellent selective fluorescence response toward Fe3+ (Ni2+) and the stoichiometry ratio of L1-Fe3+ and L2-Ni2+ were 1:1. The detection lim...

The binary MoO3 – TeO2 glasses doped with 0–0.5 mol% of Ni2 + ions were prepared by the melt-quenching technique using inorganic salts and acids as starting materials. The optical transmission spectra of all prepared glasses were studied in the wavelength range 0.5–6 μm. Two broad bands with...

A novel nickel imprinted polymer (Ni-IP) was synthesized by using precipitation polymerization method with 4-vinyl pyridine as ligand and methacrylic acid as functional monomer and it was employed to eliminate the nickel (II) ions from the aqueous media. In this work, various effects of preparat...

In previous investigations on the magnetic properties of Ni2 +-vermiculite intercalation compounds from Santa Olalla, it was considered that each of the two anomalies in the real component of the ac magnetic susceptibility exhibited by these compounds could be related to the spin dynamics of the...

In this study, novel macro porous Ni2+-imprinted chitosan foam adsorbents (F-IIP) were prepared using sodium bicarbonate and glycerine to obtain a porogen for adsorbing nickel ions from aqueous solutions. The use of the ion-imprinting technique for adsorbents preparation improved the nickel ion ...

The study for the extraction of nickel (Ni2+ ions) from aqueous solution by applying surface modified molecularly imprinted ferrite nanomaterials as an adsorbent. Molecularly imprinted ferrite nanoparticles were synthesized by co-precipitation method, using ferrous and ferric salts in basic medi...

In order to expand the structure–activity relationship (SAR) studies on Thiocarbamates (TCs), a recently discovered class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors, 38 analogues of the lead O-[2-(2-pyridyl)ethyl]-N-phenylthiocarbamate 1 were prepared by parallel solution-p...

We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified as potent tachykinin NK1 receptor antagonists by structural modification of the 3-benzhydrylpiperidone derivative through high-throughput screening. N-{2-[(3R,4S)-4-({2-Methoxy-5-[5-(trifluoromethy...

Retinoic acid receptor-related orphan receptors (RORs) are ligand-dependent transcriptional factors and members of the nuclear receptor superfamily. RORs regulate inflammation, metabolic disorders and circadian rhythm. RORγ is a promising therapeutic drug target for treating Th17-mediated autoi...

The present article describes the synthesis and enzyme inhibitory kinetics of methyl[2-(arylmethylene-hydrazono)-4-oxo-thiazolidin-5-ylidene]acetates 5a–j as mushroom tyrosinase inhibitors. The title compounds were synthesized via cyclocondensation of thiosemicarbazones 3a–j with dimethyl but-...

Pyridine moieties were introduced into chitosan by nucleophilic substitution to afford N-(1-carboxybutyl-4-pyridinium) chitosan chloride (pyridine chitosan). The resulting chitosan derivative was well characterized, and its antifungal activity was examined, based on the inhibition of mycelial gr...