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Hangzhou Hysen Pharma co.,Ltd.

we are professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a R&D center in Hangzhou. I

Levothyroxine Sodium CAS:55-03-8

Cas:55-03-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Levothyroxine sodium Manufacturer/High quality/Best price/In stock

Cas:55-03-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Sodium Levothyroxine supplier in China

Cas:55-03-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Levothyroxine sodium manufacturer with low price

Cas:55-03-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:2-8°C Package:100g/bottle; 1kg/foil bag

Manufacturer supply Levothyroxine sodium CAS 55-03-8 of USP standard

Cas:55-03-8

Min.Order:100 Gram

FOB Price: $2.2 / 2.8

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Levothyroxine sodium 55-03-8 GMP Manufacturer

Cas:55-03-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Levothyroxine sodium

Cas:55-03-8

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C15H20I4NNaO9 Levothyroxine sodium 55-03-8

Cas:55-03-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 55-03-8 with competitive price

Cas:55-03-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Levothyroxine sodium/ LIDE PHARMA- Factory supply / Best price

Cas:55-03-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name: Levothyroxine sodium CAS No.: 55-03-8 Molecular formula: C15H20I4NNaO9 Molecular weight: 888 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Pack

Levothyroxine sodium

Cas:55-03-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1) 55-03-8

Cas:55-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Levothyroxine sodium with CAS:55-03-8

Cas:55-03-8

Min.Order:10 Gram

FOB Price: $164.0 / 172.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Levothyroxine sodium CAS55-03-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed

Levothyroxine sodium CAS55-03-8

Cas:55-03-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)

Cas:55-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

T4 (LEVOTHYROXINE SODIUM) factory bulk supply

Cas:55-03-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)

Cas:55-03-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

T4 (LEVOTHYROXINE SODIUM)

Cas:55-03-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

Factory supply Levothyroxine Sodium powder with best price

Cas:55-03-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Levothyroxine sodium

Cas:55-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Levothyroxine sodium

Cas:55-03-8

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply levothyroxine sodium

Cas:55-03-8

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)

Cas:55-03-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Sodium Levothyroxine

Cas:55-03-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

High purity levothyroxine sodium 55-03-8 in stock immediately delivery good supplierAppearance:Powder Storage:Dry and ventilated Package:according to customers' requirements Application:APIs Transportation:By air(EMS or EUB or FedEx or TNT ect...) o

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:One of the thyroid

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)

Cas:55-03-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Levothyroxine sodium

Cas:55-03-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Levothyroxine sodium

Cas:55-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferLevothyroxine sodium

Cas:55-03-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Levothyroxinesodium

Cas:55-03-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

L-thyroxine
51-48-9

L-thyroxine

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
With sodium carbonate In water Reflux;98%
Stage #1: L-thyroxine With sulfuric acid; ammonia In butan-1-ol at 5 - 65℃; for 1h; pH=8;
Stage #2: With sodium hydroxide In propan-1-ol; butan-1-ol at 25 - 50℃; pH=10;
83%
With sodium carbonate Reflux;79.2%
With sodium carbonate In propan-1-ol; water at 80 - 90℃; for 1h;68%
O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Stage #1: O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt With sodium hydroxide In water at 25 - 30℃; pH=~ 12 - 13;
Stage #2: With hydrogenchloride In water pH=2 - 3; Product distribution / selectivity;
92%
With pyrographite; sodium hydroxide; sodium sulfite In water at 20℃; for 0.5h;84%
Stage #1: O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt With acetic acid In propan-1-ol; water at 55 - 60℃;
Stage #2: With sodium carbonate In propan-1-ol; water at 80 - 90℃;
81%
3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 1 h
1.2: 2 h / 20 - 40 °C
2.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
2.2: 2 h / 20 - 30 °C
3.1: acetic acid; hydrogen iodide / 5 h / 100 °C
4.1: methylamine / methanol / 25 - 30 °C
4.2: -8 - 0 °C
4.3: 15 - 20 °C
5.1: sulfuric acid; ammonia / butan-1-ol / 1 h / 5 - 65 °C / pH 8
5.2: 25 - 50 °C / pH 10
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydroxide / water / 0 - 15 °C
2.1: 0.5 h / 20 °C
2.2: 1 h / 20 - 50 °C
3.1: copper(II) perchlorate hexahydrate / dichloromethane / 0.17 h / 25 °C
3.2: 3 h / 25 °C
4.1: acetic acid; hydrogen iodide / 4 h / 120 °C
5.1: sodium iodide / water / 0.08 h / 20 °C / Inert atmosphere
5.2: 0.5 h / 20 °C
5.3: 1.25 h / 20 - 60 °C
6.1: sodium hydroxide; sodium sulfite; pyrographite / water / 0.5 h / 20 °C
View Scheme
3,5-diiodo L-tyrosine copper complex

3,5-diiodo L-tyrosine copper complex

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
1.2: 2 h / 20 - 30 °C
2.1: acetic acid; hydrogen iodide / 5 h / 100 °C
3.1: methylamine / methanol / 25 - 30 °C
3.2: -8 - 0 °C
3.3: 15 - 20 °C
4.1: sulfuric acid; ammonia / butan-1-ol / 1 h / 5 - 65 °C / pH 8
4.2: 25 - 50 °C / pH 10
View Scheme
4,4'-dimethoxydiphenyliodonium iodide
6293-71-6

4,4'-dimethoxydiphenyliodonium iodide

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
1.2: 2 h / 20 - 30 °C
2.1: acetic acid; hydrogen iodide / 5 h / 100 °C
3.1: methylamine / methanol / 25 - 30 °C
3.2: -8 - 0 °C
3.3: 15 - 20 °C
4.1: sulfuric acid; ammonia / butan-1-ol / 1 h / 5 - 65 °C / pH 8
4.2: 25 - 50 °C / pH 10
View Scheme
2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid
94345-95-6

2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid; hydrogen iodide / 5 h / 100 °C
2.1: methylamine / methanol / 25 - 30 °C
2.2: -8 - 0 °C
2.3: 15 - 20 °C
3.1: sulfuric acid; ammonia / butan-1-ol / 1 h / 5 - 65 °C / pH 8
3.2: 25 - 50 °C / pH 10
View Scheme
L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tert-butylamine; sodium iodide; sodium hypochlorite / methanol / 20 - 30 °C
2: sodium carbonate / water; propan-1-ol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tert-butylamine; sodium iodide; sodium hypochlorite / methanol / 20 - 30 °C
2.1: sodium hydroxide / water; propan-1-ol / 80 - 90 °C
3.1: acetic acid / water; propan-1-ol / 55 - 60 °C
3.2: 80 - 90 °C
View Scheme
{Cu(HOC6H2I2CH2CH(NH2)COO)2}
49553-16-4

{Cu(HOC6H2I2CH2CH(NH2)COO)2}

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 90 °C
2: hydrogenchloride / water / 5 h / 100 °C
3: potassium iodide; iodine; sodium hydroxide / water / -10 - 10 °C
4: sodium carbonate / Reflux
View Scheme
2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid
94345-95-6

2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 5 h / 100 °C
2: potassium iodide; iodine; sodium hydroxide / water / -10 - 10 °C
3: sodium carbonate / Reflux
View Scheme
4,4'-dimethoxy-diphenyliodonium bromide
19231-06-2

4,4'-dimethoxy-diphenyliodonium bromide

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 90 °C
2: hydrogenchloride / water / 5 h / 100 °C
3: potassium iodide; iodine; sodium hydroxide / water / -10 - 10 °C
4: sodium carbonate / Reflux
View Scheme
N-acetyl-O-(4-methoxyphenyl)-3,5-diiodo-L-tyrosine ethyl ester
83249-56-3

N-acetyl-O-(4-methoxyphenyl)-3,5-diiodo-L-tyrosine ethyl ester

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid; hydrogen iodide / 4 h / 120 °C
2.1: sodium iodide / water / 0.08 h / 20 °C / Inert atmosphere
2.2: 0.5 h / 20 °C
2.3: 1.25 h / 20 - 60 °C
3.1: sodium hydroxide; sodium sulfite; pyrographite / water / 0.5 h / 20 °C
View Scheme
N-acetyl-3,5-diiodo-L-tyrosine
1027-28-7

N-acetyl-3,5-diiodo-L-tyrosine

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 0.5 h / 20 °C
1.2: 1 h / 20 - 50 °C
2.1: copper(II) perchlorate hexahydrate / dichloromethane / 0.17 h / 25 °C
2.2: 3 h / 25 °C
3.1: acetic acid; hydrogen iodide / 4 h / 120 °C
4.1: sodium iodide / water / 0.08 h / 20 °C / Inert atmosphere
4.2: 0.5 h / 20 °C
4.3: 1.25 h / 20 - 60 °C
5.1: sodium hydroxide; sodium sulfite; pyrographite / water / 0.5 h / 20 °C
View Scheme
N-acetyl-3,5-diiodo-L-tyrosine ethyl ester
21959-36-4

N-acetyl-3,5-diiodo-L-tyrosine ethyl ester

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: copper(II) perchlorate hexahydrate / dichloromethane / 0.17 h / 25 °C
1.2: 3 h / 25 °C
2.1: acetic acid; hydrogen iodide / 4 h / 120 °C
3.1: sodium iodide / water / 0.08 h / 20 °C / Inert atmosphere
3.2: 0.5 h / 20 °C
3.3: 1.25 h / 20 - 60 °C
4.1: sodium hydroxide; sodium sulfite; pyrographite / water / 0.5 h / 20 °C
View Scheme
L-thyroxine sodium
55-03-8

L-thyroxine sodium

O-[6-{6-[4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}-1-oxobutyl]aminohexanoyl}aminohexanoyl]gramicidin A

O-[6-{6-[4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}-1-oxobutyl]aminohexanoyl}aminohexanoyl]gramicidin A

O-[6-[(6-[3-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethylaminocarbonyl}propionylamino]-1-oxohexyl)amino]-1-oxohexyl]gramicidin A

O-[6-[(6-[3-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethylaminocarbonyl}propionylamino]-1-oxohexyl)amino]-1-oxohexyl]gramicidin A

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane at 20℃; for 16h;63%
L-thyroxine sodium
55-03-8

L-thyroxine sodium

O-[6-(6-[6-{6-[4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}-1-oxobutyl]aminohexanoyl}aminohexanoyl]aminohexanoyl)aminohexanoyl]gramicidin A

O-[6-(6-[6-{6-[4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}-1-oxobutyl]aminohexanoyl}aminohexanoyl]aminohexanoyl)aminohexanoyl]gramicidin A

O-{6-[6-({6-[(6-[3-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethylaminocarbonyl}propionylamino]-1-oxohexyl)amino]-1-oxohexyl}amino)-1-oxohexyl]amino-1-oxohexyl}gramicidin A

O-{6-[6-({6-[(6-[3-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethylaminocarbonyl}propionylamino]-1-oxohexyl)amino]-1-oxohexyl}amino)-1-oxohexyl]amino-1-oxohexyl}gramicidin A

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane at 20℃; for 16h;51%
L-thyroxine sodium
55-03-8

L-thyroxine sodium

O-succinylgramicidin A

O-succinylgramicidin A

O-[4-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethyl}amino-4-oxobutanoyl]gramicidin A

O-[4-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethyl}amino-4-oxobutanoyl]gramicidin A

Conditions
ConditionsYield
Stage #1: O-succinylgramicidin A With triethylamine; isobutyl chloroformate In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: L-thyroxine sodium In tetrahydrofuran; water at 20℃;
19%
L-thyroxine sodium
55-03-8

L-thyroxine sodium

O-[6-[4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}-1-oxobutyl]aminohexanoyl]gramicidin A

O-[6-[4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}-1-oxobutyl]aminohexanoyl]gramicidin A

O-[6-[3-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethylaminocarbonyl}propionylamino]-1-oxohexyl]gramicidin A

O-[6-[3-{(1S)-1-hydroxycarbonyl-2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]ethylaminocarbonyl}propionylamino]-1-oxohexyl]gramicidin A

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane at 20℃; for 18h;20 mg
L-thyroxine sodium
55-03-8

L-thyroxine sodium

N-trifluoroacetyl thyroxine

N-trifluoroacetyl thyroxine

Conditions
ConditionsYield
With sodium chloride; trifluoroacetic acid; trifluoroacetic anhydride In methanol; chloroform; ethyl acetate; Petroleum ether
L-thyroxine sodium
55-03-8

L-thyroxine sodium

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid In water; glycerol
With ethylenediaminetetraacetic acid In water; glycerol
With ethylenediaminetetraacetic acid In water; glycerol
With ethylenediaminetetraacetic acid In water; glycerol
With ethylenediaminetetraacetic acid In glycerol
L-thyroxine sodium
55-03-8

L-thyroxine sodium

O2,O3-diacetyl-tartaric acid anhydride
122376-19-6

O2,O3-diacetyl-tartaric acid anhydride

C23H19I4NO11

C23H19I4NO11

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20 - 25℃; for 1h;900 mg

Raw Materials

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