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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

L-Thyroxine Manufacturer/High quality/Best price/In stock

Cas:51-48-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance An odorless almost white or buffcolored powder Conform Specific rotation

High purity Various Specifications L-Thyroxine CAS:51-48-9

Cas:51-48-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Kono Chem Co.,Ltd

Founded in 2014, Kono Chem Co., Ltd is an export-oriented production enterprise supported by the State Department of Commerce. Kono Chem covers an area of 312,000 square meters, with scientific and technological personnel accounting for more than 35%

L-Thyroxine Powder

Cas:51-48-9

Min.Order:1 Kilogram

FOB Price: $299.0 / 300.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for L-Thyroxine Cas 51-48-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:An odorless almost white or buffcolored powder Storage:Store in 2-8℃ Packa

Factory supply high quality L-Thyroxine Cas 51-48-9 with favorable price

Cas:51-48-9

Min.Order:100 Gram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Levothyroxine

Cas:51-48-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% L-Thyroxine 51-48-9 GMP Manufacturer

Cas:51-48-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

L-Thyroxine

Cas:51-48-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

L-Thyroxine

Cas:51-48-9

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

High CAS 51-48-9 with fast shipping

Cas:51-48-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

L-Thyroxine/ LIDE PHARMA- Factory supply / Best price

Cas:51-48-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name: L-Thyroxine CAS No.: 51-48-9 Molecular formula: C15H11I4NO4 Molecular weight: 776 Appearance: beige powder Appearance: white powder Storage:Store in cool and dry place,

L-Thyroxine CAS:51-48-9

Cas:51-48-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo- 51-48-9

Cas:51-48-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

L-Thyroxine/CAS:51-48-9

Cas:51-48-9

Min.Order:100 Gram

FOB Price: $286.0 / 313.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

L-Thyroxine CAS: 51-48-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

L-Thyroxine CAS: 51-48-9

Cas:51-48-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, Nuevo Laredo, Mexico, Vancouver, Canada, Amsterdam, The Netherlands and Melbourne, Australia. Overseas warehouses can provide some of the best selling products. We look forward to cooperating with strong loc

T4 L-Thyroxine cas 51-48-9 tablets

Cas:51-48-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Levothyroxine

Cas:51-48-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Professional Supplier Provide Levothyroxine// T4// L-Thyroxine

Cas:51-48-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-

Cas:51-48-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:Crystalline Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/C

L-Thyroxine

Cas:51-48-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

Factory supply L-thyroxine powder with best price

Cas:51-48-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

L-Thyroxine

Cas:51-48-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

UNBOUND L-THYROXINE

Cas:51-48-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

L-Thyroxine

Cas:51-48-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

L-Thyroxine

Cas:51-48-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

L-Thyroxine

Cas:51-48-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

L-Thyroxine

Cas:51-48-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Binbo Biological Co., Ltd

Product Name: L-Thyroxine Synonyms: 3,5,3’,5’-tetraiodothyronine;beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine;l-3,5,3’,5’-tetraiodothyronine;l-t4;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiod

CAS 51-48-9 Thyroid Hormone T4 Levothyroxine

Cas:51-48-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi New nine Material Technology Co., Ltd.

Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Professional R&D

L-Thyroxine Manufacturer/High quality/Best price/In stock CAS NO.51-48-9

Cas:51-48-9

Min.Order:10 Gram

FOB Price: $8.0 / 10.0

Type:Trading Company

inquiry

Synthetic route

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With sodium hypochlorite; tert-butylamine; sodium iodide In methanol at 20 - 30℃; Reagent/catalyst; Solvent;100%
With iodine; methylamine; potassium iodide In water at 0 - 5℃; for 2h;95%
With iodine; potassium iodide; sodium hydroxide In water at -10 - 10℃; Reagent/catalyst; Temperature;76.7%
With water; iodine; ethylamine; potassium iodide
With ammonia; iodine; potassium iodide
L-thyroxine, sodium salt hexahydrate

L-thyroxine, sodium salt hexahydrate

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With hydrogenchloride In methanol; dimethyl sulfoxide96%
3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

5,7-diiodo-1-oxaspiro[2.5]octa-4,7-dien-6-one

5,7-diiodo-1-oxaspiro[2.5]octa-4,7-dien-6-one

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 24℃; for 16h; 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH);94%
3,3′-diiodothyronine
70-40-6

3,3′-diiodothyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Stage #1: 3,3′-diiodothyronine With methylamine In methanol at 25 - 30℃;
Stage #2: With iodine In methanol at -8 - 0℃;
Stage #3: With potassium dihydrogenphosphate; sodium hydrogensulfite In methanol at 15 - 20℃;
91.2%
3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide; butan-1-ol
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 1 h
1.2: 2 h / 20 - 40 °C
2.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
2.2: 2 h / 20 - 30 °C
3.1: acetic acid; hydrogen iodide / 5 h / 100 °C
4.1: methylamine / methanol / 25 - 30 °C
4.2: -8 - 0 °C
4.3: 15 - 20 °C
View Scheme
N-acetyl-3,5-diiodo-L-tyrosine
1027-28-7

N-acetyl-3,5-diiodo-L-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With air; water at 37℃; Erhitzen des Reaktionsprodukts mit wss. Salzsaeure und Essigsaeure;
3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

((7R,8S)-8-Hydroxy-5,7-diiodo-6-oxo-1-oxa-spiro[2.5]oct-4-en-2-yl)-oxo-acetic acid

((7R,8S)-8-Hydroxy-5,7-diiodo-6-oxo-1-oxa-spiro[2.5]oct-4-en-2-yl)-oxo-acetic acid

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
at 0℃; for 0.75h; Yield given;
iodoacetamide
27059-94-5

iodoacetamide

3,5-diiodo-thyronine

3,5-diiodo-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With methanol; triethylamine
1-methyl-4-nitrosobenzene
623-11-0

1-methyl-4-nitrosobenzene

3,5-diiodo-l-tyrosine
300-39-0

3,5-diiodo-l-tyrosine

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

butan-1-ol
71-36-3

butan-1-ol

L-thyroxine
51-48-9

L-thyroxine

casein

casein

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Jodierung und anschliessende Hydrolyse;
iodine
7553-56-2

iodine

aqueous sodium hydrogencarbonate solution

aqueous sodium hydrogencarbonate solution

L-thyroxine
51-48-9

L-thyroxine

4-Hydroxymethyl-2,6-diiodo-cyclohexa-2,5-dienone

4-Hydroxymethyl-2,6-diiodo-cyclohexa-2,5-dienone

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 37 percent / NaBiO3 / ethyl acetate; acetic acid; H2O / 4 h
2: 94 percent / dimethylformamide / 16 h / 24 °C / 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH)
View Scheme
3,5-diiodo-DL-thyronine
534-51-0

3,5-diiodo-DL-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: (-)-α-phenethylamine; water
3: hydrobromic acid
4: concentrated ammonia; potassium iodide; iodine
View Scheme
3.5-diiodo-N.O-diacetyl-L-tyrosine
96679-34-4

3.5-diiodo-N.O-diacetyl-L-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaOH solution
2: water; air / 37 °C / Erhitzen des Reaktionsprodukts mit wss. Salzsaeure und Essigsaeure
View Scheme
N-formyl-3,5-diiodo-DL-thyronine
94298-44-9

N-formyl-3,5-diiodo-DL-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (-)-α-phenethylamine; water
2: hydrobromic acid
3: concentrated ammonia; potassium iodide; iodine
View Scheme
N-formyl-3,5-diiodo-L-thyronine
94298-44-9, 120408-14-2

N-formyl-3,5-diiodo-L-thyronine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrobromic acid
2: concentrated ammonia; potassium iodide; iodine
View Scheme
L-tyrosine
60-18-4

L-tyrosine

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; iodine monochloride
2: aq. NaOH solution; butanol-(1); aqueous hydrogen peroxide
View Scheme
Multi-step reaction with 8 steps
1: hydrogenchloride / water / 24 h / 20 °C
2: sodium hydrogencarbonate / water; tetrahydrofuran / 24 h / 20 °C
3: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C
4: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
6: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
7: lithium hydroxide / water; methanol / 1.5 h / 4 °C
8: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 1h; pH=~ 4 - 5;
thyroxine
300-30-1

thyroxine

A

L-thyroxine
51-48-9

L-thyroxine

B

dextrothyroxine
51-49-0

dextrothyroxine

Conditions
ConditionsYield
With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 20℃; Purification / work up;
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate
1431868-09-5

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / water; methanol / 1.5 h / 4 °C
2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 20℃; Inert atmosphere;
L-Tyr-OMe
1080-06-4

L-Tyr-OMe

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: sodium hydrogencarbonate / water; tetrahydrofuran / 24 h / 20 °C
2: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C
3: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
5: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
6: lithium hydroxide / water; methanol / 1.5 h / 4 °C
7: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester
4326-36-7

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C
2: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
4: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
5: lithium hydroxide / water; methanol / 1.5 h / 4 °C
6: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate
128781-80-6

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
3: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
4: lithium hydroxide / water; methanol / 1.5 h / 4 °C
5: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
C30H43I2NO6Si
1016161-91-3

C30H43I2NO6Si

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C
2: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
3: lithium hydroxide / water; methanol / 1.5 h / 4 °C
4: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
C21H23I2NO6
1431868-05-1

C21H23I2NO6

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C
2: lithium hydroxide / water; methanol / 1.5 h / 4 °C
3: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
3,5-diiodo L-tyrosine copper complex

3,5-diiodo L-tyrosine copper complex

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
1.2: 2 h / 20 - 30 °C
2.1: acetic acid; hydrogen iodide / 5 h / 100 °C
3.1: methylamine / methanol / 25 - 30 °C
3.2: -8 - 0 °C
3.3: 15 - 20 °C
View Scheme
4,4'-dimethoxydiphenyliodonium iodide
6293-71-6

4,4'-dimethoxydiphenyliodonium iodide

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / water; butan-1-ol / 2 h / 20 - 90 °C
1.2: 2 h / 20 - 30 °C
2.1: acetic acid; hydrogen iodide / 5 h / 100 °C
3.1: methylamine / methanol / 25 - 30 °C
3.2: -8 - 0 °C
3.3: 15 - 20 °C
View Scheme
2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid
94345-95-6

2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid

L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid; hydrogen iodide / 5 h / 100 °C
2.1: methylamine / methanol / 25 - 30 °C
2.2: -8 - 0 °C
2.3: 15 - 20 °C
View Scheme
L-Lactic acid
79-33-4

L-Lactic acid

L-Tartaric acid
87-69-4

L-Tartaric acid

L-thyroxine
51-48-9

L-thyroxine

C4H6O6*C15H11I4NO4*C3H6O3

C4H6O6*C15H11I4NO4*C3H6O3

Conditions
ConditionsYield
at 10 - 20℃; for 168h;99.5%
L-thyroxine
51-48-9

L-thyroxine

L-thyroxine sodium
55-03-8

L-thyroxine sodium

Conditions
ConditionsYield
With sodium carbonate In water Reflux;98%
Stage #1: L-thyroxine With sulfuric acid; ammonia In butan-1-ol at 5 - 65℃; for 1h; pH=8;
Stage #2: With sodium hydroxide In propan-1-ol; butan-1-ol at 25 - 50℃; pH=10;
83%
With sodium carbonate Reflux;79.2%
With sodium carbonate In propan-1-ol; water at 80 - 90℃; for 1h;68%
L-Tartaric acid
87-69-4

L-Tartaric acid

L-thyroxine
51-48-9

L-thyroxine

C4H6O6*C15H11I4NO4

C4H6O6*C15H11I4NO4

Conditions
ConditionsYield
In ethanol for 72h;96%
L-thyroxine
51-48-9

L-thyroxine

Conditions
ConditionsYield
With sodium sulfite In water at 130℃; for 2h; Sealed tube; Microwave irradiation; Green chemistry;92%
L-thyroxine
51-48-9

L-thyroxine

O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine disodium salt

Conditions
ConditionsYield
With sodium hydroxide In propan-1-ol; water at 80 - 90℃;91%
With sodium hydroxide In ethanol for 0.25h; Reflux;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-thyroxine
51-48-9

L-thyroxine

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 2h;90%
In N,N-dimethyl-formamide at 20℃; for 2h;90%
With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;50%
With sodium carbonate In dimethyl sulfoxide
With hydrogenchloride; sodium hydrogencarbonate In N-methyl-acetamide; methanol; water4.2 g (4.8 mmol, 83%)
L-thyroxine
51-48-9

L-thyroxine

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl (S)-2-amino-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate hydrochloride

methyl (S)-2-amino-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water87%
With hydrogenchloride In methanol; water87%
Boc-Val-ONSu
3392-12-9

Boc-Val-ONSu

L-thyroxine
51-48-9

L-thyroxine

N-(t-butoxycarbonyl)-L-valyl-L-thyroxine

N-(t-butoxycarbonyl)-L-valyl-L-thyroxine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water at 20℃; Condensation;85%
L-thyroxine
51-48-9

L-thyroxine

oxalic acid
144-62-7

oxalic acid

C15H11I4NO4*C2H2O4

C15H11I4NO4*C2H2O4

Conditions
ConditionsYield
In ethanol at 10 - 20℃; for 120h;82.5%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

L-thyroxine
51-48-9

L-thyroxine

C16H9I4NO5

C16H9I4NO5

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; for 1h;80%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

L-thyroxine
51-48-9

L-thyroxine

L-thyroxine-N-carboxyanhydride

L-thyroxine-N-carboxyanhydride

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;80%
L-thyroxine
51-48-9

L-thyroxine

α-(N-Trifluoroacetyl)amino-β-[3,5-diiodo-4-(3',5'-diiodo-4'-hydroxyphenoxy)phenyl] propanoic acid
73122-01-7

α-(N-Trifluoroacetyl)amino-β-[3,5-diiodo-4-(3',5'-diiodo-4'-hydroxyphenoxy)phenyl] propanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate; trifluoroacetic acid; trifluoroacetic anhydride In water; ethyl acetate70.5%
With sodium hydrogencarbonate; trifluoroacetic acid; trifluoroacetic anhydride In water; ethyl acetate70.5%
L-thyroxine
51-48-9

L-thyroxine

ethyl iodide
75-03-6

ethyl iodide

2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
1021496-83-2

2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 2h;62%
In N,N-dimethyl-formamide at 20℃; for 2h;62%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

L-thyroxine
51-48-9

L-thyroxine

2-(butyrylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
806620-06-4

2-(butyrylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;50%
Stage #1: L-thyroxine With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: butanoic acid anhydride In N,N-dimethyl-formamide at 20℃;
45%
Stage #1: L-thyroxine With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: butanoic acid anhydride In N,N-dimethyl-formamide at 20℃; for 0.75h;
45%
L-thyroxine
51-48-9

L-thyroxine

acetic anhydride
108-24-7

acetic anhydride

2-acetamido-3-[4-(4-acetoxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
26041-53-2

2-acetamido-3-[4-(4-acetoxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

Conditions
ConditionsYield
Stage #1: L-thyroxine With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: acetic anhydride In N,N-dimethyl-formamide at 20℃;
50%
With pyridine at 0 - 23℃; for 12h; Inert atmosphere;
L-thyroxine
51-48-9

L-thyroxine

ethyl iodide
75-03-6

ethyl iodide

ethyl 2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
1083039-06-8

ethyl 2-(ethylamino)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate

Conditions
ConditionsYield
Stage #1: L-thyroxine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃; for 1h;
50%
Stage #1: L-thyroxine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃;
10%
L-thyroxine
51-48-9

L-thyroxine

biotinamidocaproate N-hydroxysuccinimide ester
89889-52-1

biotinamidocaproate N-hydroxysuccinimide ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; dimethyl sulfoxide at 20℃; Cooling with ice;42%
L-thyroxine
51-48-9

L-thyroxine

L-thyroxine sulfate

L-thyroxine sulfate

Conditions
ConditionsYield
With chlorosulfonic acid; trifluoroacetic acid at 0℃; for 0.166667h;40%
L-thyroxine
51-48-9

L-thyroxine

methyl iodide
74-88-4

methyl iodide

potassium 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-(methylamino)propanoate dihydrate
1234572-93-0

potassium 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-(methylamino)propanoate dihydrate

Conditions
ConditionsYield
Stage #1: L-thyroxine; methyl iodide In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With potassium carbonate In N,N-dimethyl-formamide
24%
Stage #1: L-thyroxine; methyl iodide With triiodothyronine In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With potassium carbonate In water; N,N-dimethyl-formamide
24%
L-thyroxine
51-48-9

L-thyroxine

O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo-L-tyrosine sodium salt

O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo-L-tyrosine sodium salt

Conditions
ConditionsYield
Stage #1: L-thyroxine With chlorosulfonic acid In N,N-dimethyl acetamide at 0 - 20℃; for 5h; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate; sodium carbonate In N,N-dimethyl acetamide; water for 1.5h;
18%
L-thyroxine
51-48-9

L-thyroxine

O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine
1596-67-4

O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine

Conditions
ConditionsYield
With potassium hydroxide; palladium Hydrogenation;
With sodium tetrahydroborate; C10H8STe; D,L-dithiothreitol In aq. phosphate buffer at 37℃; for 0.5h; pH=7.5; Reagent/catalyst;
L-thyroxine
51-48-9

L-thyroxine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine
97738-15-3

N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine

Conditions
ConditionsYield
With ethyl acetate
L-thyroxine
51-48-9

L-thyroxine

dimethyl sulfate
77-78-1

dimethyl sulfate

4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-trans-cinnamic acid

4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-trans-cinnamic acid

Conditions
ConditionsYield
With sodium hydroxide
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