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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Propylthiouracil manufacturer with low price

Cas:51-52-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white powder Storage:Refrigerator Package:1kg

USP standard Propylthiouracil CAS 51-52-5 supplied by manufacturer

Cas:51-52-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Propylthiouracil

Cas:51-52-5

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Propylthiouracil 51-52-5 GMP Manufacturer

Cas:51-52-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Propylthiouracil

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Propylthiouracil

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Propyl-2-thiouracil

Cas:51-52-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:4-Hydroxy-2-mercapto-6-propylpyrimidine CAS no: 51-52-5 Grade:Medical, scientific research, export Molecular formula:C7H10N2OS Molecular weight:170.2321 Product Quality 12 years of chemical raw materials Mature operation of the industr

4-Hydroxy-2-mercapto-6-propylpyrimidine/cas:51-52-5/Raw material supply

Cas:51-52-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 3.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Propylthiouracil

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 51-52-5 with best quality

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Good quality 99.5% pure powder Propylthiouracil cas:51-52-5 for sale,manufacture of China

Cas:51-52-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Propylthiouracil CAS51-52-5

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Propylthiouracil CAS:51-52-5 MF: C7H10N2OS Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:API Transportation:By sea or by air Port:Qingdao Port

Propylthiouracil

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

Pharmacy Raw Material Propylthiouracil CAS No 51-52-5

Cas:51-52-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

China Manufacturer Sell Raw Material Powder CAS 51-52-5 Propylthiouracil

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4(1H)-Pyrimidinone,2,3-dihydro-6-propyl-2-thioxo- 51-52-5

Cas:51-52-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Propylthiouracil

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $70.0 / 78.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Propylthiouracil CAS:51-52-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Propylthiouracil CAS:51-52-5

Cas:51-52-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4(1H)-Pyrimidinone,2,3-dihydro-6-propyl-2-thioxo-

Cas:51-52-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4(1H)-Pyrimidinone,2,3-dihydro-6-propyl-2-thioxo-/ LIDE PHARMA- Factory supply / Best price

Cas:51-52-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

Propylthiouracil CAS 51-52-5

Cas:51-52-5

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4(1H)-Pyrimidinone,2,3-dihydro-6-propyl-2-thioxo-

Cas:51-52-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Propylthiouracil

Cas:51-52-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

PROPYLTHIOURACIL

Cas:51-52-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Propylthiouracil

Cas:51-52-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Propylthiouracil manufacturer

Cas:51-52-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hefei TNJ chemical industry co.,ltd

APIs Best price; High Quality; Superior Service; Fast delivery. Appearance:White crystalline powder Storage:Stored in a cool & dried place Package:25kg/fiber drum or according to your requirements Application:Pharmaceutical Material Por

Good Quality Propylthiouracil,CAS. 51-52-5

Cas:51-52-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Pharmaceutical Intermediate Propylthiouracil

Cas:51-52-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Good quality 99.5% pure powder Propylthiouracil cas:51-52-5 for sale,manufacture of China

Cas:51-52-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:ant

Propylthiouracil

Cas:51-52-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

ethyl butyroyl acetate
3249-68-1

ethyl butyroyl acetate

thiourea
17356-08-0

thiourea

propylthiouracil
51-52-5

propylthiouracil

Conditions
ConditionsYield
Reflux;81%
With potassium hydroxide In ethanol at 80℃; for 5h;41%
With sodium ethanolate
thiourea
17356-08-0

thiourea

methyl 3-oxohexanoate
30414-54-1

methyl 3-oxohexanoate

propylthiouracil
51-52-5

propylthiouracil

Conditions
ConditionsYield
With potassium carbonate In water at 70 - 105℃; for 3h;78%
With sodium ethanolate In ethanol at 100℃; Inert atmosphere;33%
Heating;
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

dimethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;94%
propylthiouracil
51-52-5

propylthiouracil

1,1,3,3-tetramethylbutane isonitrile
14542-93-9

1,1,3,3-tetramethylbutane isonitrile

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

dimethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;93%
propylthiouracil
51-52-5

propylthiouracil

2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

diethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;93%
propylthiouracil
51-52-5

propylthiouracil

2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

dimethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;92%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

benzylamine
100-46-9

benzylamine

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-(tert-butyl)-2-methylpropanamide
1379463-56-5

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-(tert-butyl)-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: acetone; benzylamine at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: tert-butylisonitrile at 20℃; for 5h; Ugi condensation; Ionic liquid;
90%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

benzylamine
100-46-9

benzylamine

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexyl-2-methylpropanamide
1379463-51-0

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexyl-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: acetone; benzylamine at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: Cyclohexyl isocyanide at 20℃; for 5h; Ugi condensation; Ionic liquid;
89%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide for 6h; Heating; Green chemistry;89%
propylthiouracil
51-52-5

propylthiouracil

4-methyl-1,2-dihydroxybenzene
452-86-8

4-methyl-1,2-dihydroxybenzene

2-(4,5-dihydroxy-2-methylphenylthio)-6-propylpyrimidin-4(3H)-one

2-(4,5-dihydroxy-2-methylphenylthio)-6-propylpyrimidin-4(3H)-one

Conditions
ConditionsYield
With laccase from Agaricus bisporus In aq. phosphate buffer; ethanol at 20℃; for 13h; pH=6; Green chemistry; Enzymatic reaction; chemoselective reaction;88%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

diethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;87%
propylthiouracil
51-52-5

propylthiouracil

2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide
448224-88-2

2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide

C18H17ClN4O2S2

C18H17ClN4O2S2

Conditions
ConditionsYield
With potassium phosphate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 1h;87%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

Chloro-phenyl-acetic acid
4755-72-0, 39266-56-3

Chloro-phenyl-acetic acid

acetone
67-64-1

acetone

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;87%
propylthiouracil
51-52-5

propylthiouracil

6-propyl(1H,3H)pyrimidine-2,4-dione
13345-08-9

6-propyl(1H,3H)pyrimidine-2,4-dione

Conditions
ConditionsYield
With chloroacetic acid In water for 5h; Heating;86%
With chloroacetic acid
With chloroacetic acid Heating;
With chloroacetic acid
propylthiouracil
51-52-5

propylthiouracil

Iodoselane
116302-66-0

Iodoselane

C17H36N2OSSeSi3

C17H36N2OSSeSi3

Conditions
ConditionsYield
With triethylamine In toluene at 20℃; for 0.166667h;85%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

cyclohexanone
108-94-1

cyclohexanone

chloroacetic acid
79-11-8

chloroacetic acid

benzylamine
100-46-9

benzylamine

1-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexylcyclohexanecarboxamide
1379463-54-3

1-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexylcyclohexanecarboxamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: cyclohexanone; benzylamine at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: Cyclohexyl isocyanide at 20℃; for 5h; Ugi condensation; Ionic liquid;
85%
propylthiouracil
51-52-5

propylthiouracil

1,1,3,3-tetramethylbutane isonitrile
14542-93-9

1,1,3,3-tetramethylbutane isonitrile

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

diethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;85%
isoquinoline
119-65-3

isoquinoline

propylthiouracil
51-52-5

propylthiouracil

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(2-methoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

dimethyl 2-(2-methoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

Conditions
ConditionsYield
In toluene at 110℃; for 5h;85%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;85%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

ethylamine
75-04-7

ethylamine

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

N-cyclohexyl-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide
1379463-49-6

N-cyclohexyl-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: ethylamine; acetone at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: Cyclohexyl isocyanide at 20℃; for 5h; Ugi condensation; Ionic liquid;
83%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

chloroacetic acid
79-11-8

chloroacetic acid

pentan-3-one
96-22-0

pentan-3-one

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;83%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

Chloro-phenyl-acetic acid
4755-72-0, 39266-56-3

Chloro-phenyl-acetic acid

pentan-3-one
96-22-0

pentan-3-one

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;83%
propylthiouracil
51-52-5

propylthiouracil

methyl iodide
74-88-4

methyl iodide

2-(methylthio)-6-propylpyrimidin-4(3H)-one
5751-17-7

2-(methylthio)-6-propylpyrimidin-4(3H)-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20 - 40℃; for 4h;82%
With potassium hydroxide
With sodium hydroxide In water at 20℃;
propylthiouracil
51-52-5

propylthiouracil

4-bromo-trans-crotonic acid ethyl ester
37746-78-4

4-bromo-trans-crotonic acid ethyl ester

(5-oxo-7-propyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-acetic acid ethyl ester

(5-oxo-7-propyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;82%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

acetone
67-64-1

acetone

(R,S)-2-chloropropionic acid
598-78-7

(R,S)-2-chloropropionic acid

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)propanoate

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)propanoate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;82%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

Chloro-phenyl-acetic acid
4755-72-0, 39266-56-3

Chloro-phenyl-acetic acid

acetone
67-64-1

acetone

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;81%
propylthiouracil
51-52-5

propylthiouracil

3,3-dichloroallyl halide

3,3-dichloroallyl halide

C10H12Cl2N2OS

C10H12Cl2N2OS

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide81%
propylthiouracil
51-52-5

propylthiouracil

hydroquinone
123-31-9

hydroquinone

2-(2,5-dihydroxyphenylsulfanyl)-6-propyl-1H-pyrimidin-4-one
1611453-74-7

2-(2,5-dihydroxyphenylsulfanyl)-6-propyl-1H-pyrimidin-4-one

Conditions
ConditionsYield
In aq. phosphate buffer; water; N,N-dimethyl-formamide at 25℃; pH=6; Michael Addition; Electrolysis;80%
isoquinoline
119-65-3

isoquinoline

propylthiouracil
51-52-5

propylthiouracil

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(2-ethoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

diethyl 2-(2-ethoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

Conditions
ConditionsYield
In toluene at 110℃; for 5h;80%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

ethylamine
75-04-7

ethylamine

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

N-(tert-butyl)-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide
1379463-57-6

N-(tert-butyl)-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: ethylamine; acetone at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: tert-butylisonitrile at 20℃; for 5h; Ugi condensation; Ionic liquid;
79%
propylthiouracil
51-52-5

propylthiouracil

methyl 5-deoxy-5-iodo-2,3-isopropylidene-β-D-ribofuranoside
38838-06-1

methyl 5-deoxy-5-iodo-2,3-isopropylidene-β-D-ribofuranoside

methyl 5-deoxy-2,3-O-isopropylidene-5-(6-propyluracil-2-yl)thio-β-D-ribofuranoside
676557-71-4

methyl 5-deoxy-2,3-O-isopropylidene-5-(6-propyluracil-2-yl)thio-β-D-ribofuranoside

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 60℃; for 1h;78%
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