Polar, ethyl acetate soluble metabolites formed in incubations of dibenz[a,c]-anthracene (DB[a,c]A), dibenz[a,h]anthracene (DB[a,h]A) and the related DB[a,h]A 3,4-diol and dibenz[a,j]anthracene (DB[a,j]A) with 3-methylcholanthrene (3-MC)-induced rat liver microsomal preparations have been separa...

Experiments were performed to investigate the effects of 3 polycyclic aromatic hydrocarbons, benz[a]anthracene, dibenz[a,c]anthracene and dibenz[a,h]anthracene and K-regio epoxides and some of their related dihydrodiols on the chromosomes of Chinese hamster ovary cells in vitro. Of the 3 hydroca...

Mouse skin and human skin have been treated in vivo or in short- term organ culture with dibenz[a,h]anthracene (DB[a,h]A), the related 3,4- or 5,6-diols or the anti- or syn-3,4-diol 1,2-oxides. DNA hydrolysates have been 32P-postlabelled and the adducts present examined by HPLC using a phenyl-mo...

Timosaponin AIII (TAIII), a steroidal saponin isolated from the rhizome of Anemarrhena asphodeloides, exerted cytotoxic effect in many cancer cell lines. However, the effect of TAIII on resistant tumor cancer cells was unclear. In this study, MTT assay showed that TAIII exhibited significant cyt...

The rapid discovery of a pharmacological chaperone toward human α-Gal A for the treatment of Fabry disease is described. Two polyhydroxylated pyrrolidines with the (3R,4S,5R) configuration pattern underwent rapid substituent diversity by conjugating the primary aminomethyl moiety of each with a...

A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor effects in vitro and in vivo were investigated. Several compounds displayed good antiproliferative activity with IC50 values in low-micromolar range against three human cancer cell lines in vitro, superior to...

A new 2-methoxy-4,6-bis(4-(4-nitrostyryl)phenyl)nicotinonitrile (W-NO2) has been synthesized and the photovoltaic performances in dye‐sensitized solar cells (DSSCs) are investigated by utilizing it as co-sensitizer dye. From the study, its molar extinction coefficient value is found to be much ...

Toll-like receptors (TLRs) play significant roles in recognizing the pathogen-associated molecular patterns that induce innate immunity, and subsequently, acquired immunity. In general, TLRs have two downstream signaling pathways, the myeloid differential factor 88 (MyD88)-dependent and toll-int...

BackgroundCesarean delivery is the most common surgical procedure performed in the USA. We evaluated the postoperative analgesic properties of neuraxial hydromorphone compared to neuraxial morphine for post-cesarean delivery analgesia.

The effect of fluoride presence in a synthesis mixture on the parameters of the fine structure of SBA-15 has been studied. The amount of fluorides, the addition stage and the duration of the hydrothermal stabilization of the structure have been varied. Fluoride addition during SBA-15 synthesis i...

In this research, SBA-15 (Santa Barbara Amorphous-15) is used as the template and nickel serves as the impregnating catalyst for conversion to Ni-SBA-15. In the present test, the BET surface area of SBA-15 is 652 m2/g and Ni-SBA-15 477 m2/g. The average pore size for SBA-15 is 41 Å and for the N...

Hydrodeoxygenation (HDO) of isoeugenol has been investigated over Ni-SBA-15 and Ni-SZ-SBA-15 containing sulfated ZrO2 with Si/Zr molar ratio of 8.4. The catalysts were prepared via incipient wetness method and characterized by N2 adsorption, AAS, TPR, X-ray diffraction (XRD), thermal gravimetric...

In the present study, dendritic fibrous type SBA-15 (DFSBA-15) was successfully discovered for the first time by modulating the typical rod-like SBA-15. The synthesized DFSBA-15 was loaded with 5 wt% Ni, catalytically applied in dry reforming of methane (DRM), and catalytically compared with the...

Excess adipogenesis is a characteristic of obesity, which is associated with serious health problem, including type 2 diabetes. Here, to better understand the mechanisms for the development of adipocytes, we investigated the regulatory role of 15-(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in ...

15-Lipoxygenase-2 (15-LOX-2) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) have been considered as latent mediators of diverse biological processes including cancer. However, their functions in lung adenocarcinoma (LAC) are unclear. In this study, we aimed to determine whether 15-LOX-2/15(...

The copper-catalyzed radical cyclization (RC) of N-α-perchloroacyl cyclic ketene-N,X(X=O, NR, S)-acetals was studied. While the RC of N-acyl ketene-N,O-acetals was unsuccessful, the 5-endo cyclization of the other ketene acetals provided much better results, with the following order of cyclizat...

A novel fluorinated aromatic diamine 1,1′-bis(4-aminophenyl)-1-(3-trifluoromethylphenyl)-2,2,2-trifluoroethane (6FDAM) was synthesized in a simple procedure, which was then employed to prepare a series of fluorinated polyimides with commercial aromatic dianhydrides, such as pyromellitic dianhyd...

Polyimides with a low dielectric constant and excellent adhesion were prepared from a diamine containing phosphine oxide and fluorine groups, bis(3,3′-aminophenyl-2,3,5,6-tetrafluoro-4-trifluoromethyl phenyl phosphine oxide (mDA7FPPO), and rigid-rod type dianhydride containing fluorine groups, ...

The kinetic and mechanism of the unimolecular gas-phase elimination of 2-(dimethylamino)ethyl chloride were examined by using density functional theory methods to explain the enhanced reactivity in gas-phase elimination compared to the parent compound ethyl chloride. The plausible anchimeric ass...

The aim of the present work is to construct and investigate the properties of novel polyelectrolyte multilayers consisting of poly(N,N-dimethylamino)ethyl methacrylate (PDMAEMA) and sodium alginate (SA). The influence of PDMAEMA’s pH dependent ionization degree on the charge balance, thickness ...