In the present work, 15 new N’-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[d]imidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, 1H-NMR, 13C-NMR, and HRMS spectral data. The inhibitory activity of the compou...

An asymmetric gold(I)-catalyzed [3+2] cycloaddition of propargyl acetals/ketals and aldehydes is reported, which proceeds via stepwise migration-fragmentation of acetals/ketals and cycloaddition of the in situ generated gold-carbenoid intermediate. Various functionalized 2,5-dihydrofurans were o...

Ethyl 3-(2-(4-fluorophenyl)amino)-4-phenylthiazo)-5-yl)-3-oxopropanoate is a novel molecule with potent acetylcholinesterase inhibition property. In this research, we have developed a rapid and selective RP-HPLC bioanalytical method for quantitative measurement of the molecule. The method has be...

The asymmetric microbial reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)-propyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one to 1-(4-fluorophenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)-propyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one (Ezetimibe) by Rhodococcus fascians MO22 is described. The...

A series of 16 N1-(3-chloro-4-fluorophenyl)-N4-substituted semicarbazone derivatives were synthesized and subjected to computational pharmacokinetic studies to predict molecular properties. All the title compounds (4a–p) followed the Lipinski “Rule of Five”. The synthesized compounds were cha...

A thorough examination of weak interactions present in the crystal structure of the title compound was investigated. Intramolecular CH⋯N and F⋯S interactions make the molecule as fused 6,5,5,5,6,6-membered ring system. Two of the closely related structures show 1D-isostructurality with the title...

Very-long-chain fatty acids (VLCFAs), including hexacosanoic, tetracosanoic, and docosanoic acids, are peroxisomal disease markers, whose abnormal accumulation warrants prompt detection for timely, effective treatment. This study aimed to establish and validate a robust liquid chromatography-tan...

The Langmuir-Blodgett deposition of monolayers of docosanoic acid from aqueous subphases containing 2.5 × 10−4 M CdCl2 has been studied in detail as a function of pH. We have measured the force exerted on freshly cleaved mica substrates during transfer, enabling the dynamic contact angle to be ...

We describe results for the dynamic contact angle and transfer ratio for the deposition of docosanoic acid monolayers on to mica from CdCl2 subphases as a function of pH. The deposition changes from Z to Y type at approximately the pH corresponding to half ionisation. Deposition on OUT strokes o...

22-mercapto-1-docosanoic acid spontaneously forms a compact self-assembled (SA) monolayer on the silver (111) surface. Surface X-ray diffraction shows that the in-plane structure of this monolayer is close-packed hexagonal with an interchain spacing of approximately 4.77 Å and a chain tilt angle...

Docosanoic (C22), tetracosanoic (C24) and hexacosanoic (C26) acids are saturated very-long-chain fatty acids (VLCFA) present at trace levels in biosamples. VLCFA can be used as potential biomarkers for the diagnosis of hereditary diseases such as X-linked adrenoleukodystrophy. Because the analyt...

Activation of chemokine CC receptors subtype 2 (CCR2) plays an important role in chronic inflammatory processes such as atherosclerosis, multiple sclerosis and rheumatoid arthritis. A diverse set of spirocyclic butanamides 4 (N-benzyl-4-(3,4-dihydrospiro[[2]benzopyran-1,4′-piperidin]-1′-yl)but...

A potentiometric back-titration method for the determination of sulfate ions using a plasticized poly(vinyl chloride) membrane electrode sensitive to a titrant is described. The method is based on ion association between the excess of 2-aminoperimidinium added to the sulfate ion in the sample an...

Efficient fluorescent white organic light-emitting diodes are fabricated with the use of an efficient electro-fluorescence blue-green host material di(4-fluorophenyl)amino-di(styryl)biphenyl, doped with red dye 4-(dicyano-methylene)-2-methyl-6-(julolidin-4-yl-vinyl)-4H-pyran. One resulting two-w...

Using 2-(4-trifluoromethyl-6-fluorophenyl)pyridine (tfmfppy) as the cyclometalated ligand and tetraphenylimidodiphosphinate (tpip) derivatives as ancillary ligands, three iridium complexes (1: Ir(tfmfppy)2tpip; 2: Ir(tfmfppy)2ftpip, ftpip = tetra(4-fluorophenyl)imidodiphosphinate; 3: Ir(tfmfppy)...

Ten novel symmetric 3,5-bis(arylidene)-4-piperidone derivatives (BAPs, 1–10) and fourteen dissymmetric BAPs (11–24) were synthesized and evaluated the cytotoxicity. All of the compounds have been screened for their anti-inflammatory activity characterized by evaluating their inhibitory effects...

The density functional calculations were performed at the B3LYP/6-311++G (5D, 7F) level to find the geometrical parameters, vibrational wavenumbers and various molecular properties of three fluorophenyl derivatives, methyl 4,4″-difluoro-5′-methoxy-1,1':3′,1″-terphenyl-4′-carboxylate (M...

Tetraethyl 2,4,8,10-tetramethyl-6,12-bis(4-fluorophenyl)-3,9-dioxapentacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate (1, simplified as 6,12-bis(4-fluorophenyl)-3,9-dioxatetraasterane) was synthesized by [2 + 2] photocyclization of diethyl 2,6-dimethyl-4-(4-fluorophenyl)-4H-pyra...

The pyrazole compound 1-(2-nitrobenzoyl)3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole (I) has been synthesized and characterized by IR, NMR and X-ray diffraction methods. The compound crystallizes in the monoclinic space group C2/c with a = 36.126(5) Ǻ, b = 8.1963(7) Ǻ, c = 14.3983(18) Ǻ, β ...

Estrogens are the major female sex steroid hormones, estradiol (E2) being the most potent form in humans. Disturbing the balance between E2 and its weakly active oxidized form estrone (E1) leads to diverse types of estrogen-dependent diseases such as endometriosis or osteoporosis. 17β-Hydroxyst...