Emerging fungal phytodiseases are a food security threat and novel fungicides are in an urgent need. Herein, a series of isobutyrophenone derivatives were designed and synthesized. The derivatives exhibited excellent fungicidal activities against seven fungi. The structure-activity relationship ...

Reaction of 2-iodo-3-nitrobenzoic acid with arylalkynyl copper(I) reagent gave 3-aryl-5-nitroisocoumarins. Castro–Stephens coupling was followed by in situ Cu-catalysed ring-closure. 1H NMR and X-ray crystallography showed the cyclisations to be 6-endo, contrasting with reports of 5-exo cyclisa...

A high-performance liquid chromatographic method was devised that separates S-adenosylmethionine and related sulfur metabolites on a Radial-PAK SCX cation-exchange column using a four-step NH4COOH(NH4)2SO4 elution gradient. This new procedure permits, in a single run of 60 min, the quantitative ...

HPLC-DAD and LC-ESI-MS methods have been developed for the analysis of doxycycline (DOX), including the identification of the related impurities metacycline (MTC) and 6-epidoxycycline (EDOX) and its determination in a medicated premix. The chromatographic separations have been performed on Luna ...

Cancer is one of the leading causes of morbidity and mortality Worldwide, 19.3 million new cancer cases are expected to be identified in 2025. Among the therapeutic arsenal to cancer control one could find the Doxycycline and the nano hydroxyapatite. The Doxycycline (Dox) not only shown antibiot...

An improved method for the analysis of doxycycline hyclate by high-performance liquid chromatography using polystyrene-divinylbenzene column packings is described. The separation obtained with this method was compared with that of other, recently described methods. The improved method was examin...

Electrochemical treatment involving a coupled coagulation and floatation was performed in the removal of doxycycline hyclate (DCH) from aqueous solutions. All the experiments were carried out in an electrochemical reactor of 1.5 L which contained aluminum electrodes as cathode and anode. The rem...

Concentrated solutions of doxycycline are often added to drinking water of animals for oral antibiotic therapy. However, stability concerns of doxycycline in solution involve an accurate selection of the solvent system to ensure that the active substance will remain within the acceptance range d...

Aluminum is an attractive anode material for electrochemical energy storage and conversion devices, but the passive film and parasitic corrosion of aluminum anode in aqueous solution limits its development. Herein, we investigated the electrochemical performance of Al-2Mg alloy in alkaline elect...

The 1,3-dipolar cycloaddition of nitrile oxides generated in situ from benzohydroximinoyl chloride and triethylamine to 2-aminopyranopyridine-3-carbonitriles and 2-aminochromene-3-carbonitriles occurred chemoselectively furnishing novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrid heterocycle...

The reaction of N-(3,4-dichlorophenethyl)-N-methylamine (1) with 3-chloromethyl-5-phenyl-1,2,4-oxadiazole (2) was investigated. Employment of an equimolar amount of 1 and 2 in the presence of potassium carbonate led to the expected tertiary amine 3 (N-[(3,4-dichlorophenyl)ethyl]-N-methyl-N-[(5-p...

The reactions of 3-arylhydrazono-2,4-dioxo-4-pentafluorophenylbutanoates with hydrazine hydrate and phenylhydrazine resulted in the formation of 4-arylazo-3-pentafluorophenyl-1,2-dihydro-5H,6H-pyridazine-5,6-diones or 6-aryl-2-phenyl-7,8,9,10-tetrafluoro-2,3,4,6-tetrahydropyridazino[4,3-c]cinnol...

Several approaches to the synthesis of 5-fluoro-6-methoxy-8-nitroquinoline 5, the key intermediate required for the synthesis of 5-fluoroprimaquine, were investigated. In one approach, 5-chloro-6-methoxy-8-nitroquinoline was synthesised and treated with a variety of nucleophilic sources of fluor...

Photocatalytic selective organic transformation using photoexcited holes and electrons has attracted worldwide interest. Although extensive studies have made significant progress in dehydrogenation of alcohols, hydrogenolysis of alcohols using photoexcited electrons directly constitutes a challe...

A highly efficient and environmentally benign protocol has been developed for the construction of various potentially biologically active N-methyl-2-nitro-aryl-1H-benzo[f]chromen-3-amine derivatives using one-pot, multi-component cascade reaction of various naphthalen-2-ol, aldehydes, and (E)-N-...

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or α-keto acids) and isocyanides produced the azide inte...

Sulfonated reduced graphene oxide (rGO-SO3H, SRGO) was synthesized by introducing aryl diazonium salt of sulfanilic acid radicals onto chemically modified reduced graphene oxide (rGO) under sonication. SRGO catalyst was characterized by X-ray diffraction (XRD), Raman spectroscopy, solid state 13...

Treatment of 3-amidoindoles with phosphoryl chloride leads to a dimerization of the resulting iminochlorides to form tetrasubstituted imidazoles in moderate yield. One indole ring undergoes ring-opening to allow the formation of the imidazole ring. This strategically simple synthesis considerabl...

A one-pot Amberlite IRA-400 Cl resin catalyzed the in-situ generation of imines from various aldehydes and primary amines followed by reduction with sodium borohydride affording corresponding secondary amines. The secondary amines thus obtained were utilized for the IRA-400 Cl resin catalyzed mu...

A catalyst-free, simple and efficient protocol for N-formylation of alkyl, aryl, and heteroaryl amines with formic acid under ultrasonic irradiation at room temperature using 1-butyl-3-methylimidazolium tetrafluoroborate [Bmim]BF4 as a neutral medium is described.