In organic synthesis and polymer materials chemistry, a tert-butoxycarbonyl (BOC) group is often used as one of tools for the protection of functional groups. In this study, we carried out radical polymerization of 2-(tert-butoxycarbonyloxy)ethyl methacrylate (BHEMA) and copolymerizations of BHE...

The synthesis of a series of N-alkylated 4-(4′aminobenzyl)-2-oxazolidinones is described using a synthetically useful scheme which avoids the use of phosgene—since the derivatization is undertaken with the oxazolidin-2-one ring intact. The compounds were tested for human placental aromatase (A...

A new Schiff base, (4-(benzylideneamino)benzyl)oxazolidin-2-one has been synthesised from 4-(4-aminobenzyl)oxazolidin-2-one and salicylaldehyde by a simple condensation reaction. Single-crystal X-ray analysis of (E)-4-(4-(2-hydroxybenzylideneamino) benzyl)oxazolidin-2-one (HBOA) revealed that th...

Porphyrins modified inorganic semiconductors have been paid more attention as a platform in nanomaterials, due to the fast electronic transfer from synergistic effect. Meso-tetrakis(4-chlorophenyl)porphyrin functionalized CuFe2O4/SiO2 nanocomposites (TClPP-CuFe2O4/SiO2) were prepared by a simple...

An efficient method for the synthesis of O-substituted mandelic acids containing alkenyl, alkynyl, methoxycarbonyl, or phenacyl fragments via the Lewis acid-catalyzed reaction of 1,3-dioxolan-4-ones with different C-nucleophiles is proposed.

Copper (II) complexes are promising in the development of new synthetic models for cancer treatment. In this context, we synthesized a new copper complex containing the pharmacophore group 1,4-dioxo-2-butenyl, the Bis(((Z)-4-((4-chlorophenyl) amino)-4-oxobut-2-enoyl)oxy) copper compound and we e...

A novel bicyclic thiohydantoin fused to pyrrolidine compound, methyl 2-(4-chlorophenyl)-7a-((4-chlorophenyl)carbamothioyl)-1-oxo-5,5-diphenyl-3-thioxo-hexahydro-1H-pyrrolo[1,2-e]imidazole-6-carboxylate, was synthesized by the cyclization reaction of dimethyl 5,5-diphenylpyrrolidine-2,4-dicarboxy...

A new penta-substitued pyrrole derivative 1-(1-benzyl-4-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)ethanonewas synthesized in one pot four-component coupling reaction catalyzed by natural hydroxyapatite (Ca5(PO4)3OH). The structure of the title compound was studied using diverse spectroscopic ...

The solubilities of 5,10,15,20-tetrakis(4-chlorophenyl) porphyrin (abbreviated in p-ClTPP) in ethanol + water solvent mixtures at (293.2–333.2) K and 5,10,15,20-tetrakis(4-chlorophenyl) porphyrin manganese(III) chloride (abbreviated in p-ClTPPMnCl) in ethanol + water solvent mixtures at (303.2–...

A series of N-(2-(3,4,5-trimethoxybenzyl)-benzoxazole-5-yl)benzamide derivatives (3a–3n) was synthesized and evaluated for its in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50

The octa-3,5-diynes 3a–g have been synthesized. Subsequent oxidation of 3a–g gave the 1,8-quinone-substituted octa-3,5-diynes 4a–g. The molecular structures of the diynes α-3b, β-3b, 3c, 3e, 3f and 4f have been determined by X-ray diffraction. UV-irradiation of diyne 3c afforded in a single...

The application of the high-speed microband channel electrode to the study of the heterogeneous electron transfer kinetics of the oxidation of some N-substituted phenylenediamines is described. Experiments to investigate the standard electrochemical rate constant, k0, of the oxidation of 1,4-phe...

BackgroundOxidative stress occurs through free radical- and non-radical-mediated oxidative mechanisms, but these are poorly discriminated by most assays. A convenient assay for oxidants in human serum is based upon the Fe2+-dependent decomposition of peroxides to oxidize N,N′-diethyl-1,4-phenyl...

The RAS–RAF–MEK–ERK pathway is hyperactivated in 30% of human cancers. BRAF is a serine–threonine kinase, belonging to this pathway that is mutated with high frequency in human melanoma and other cancers thus BRAF is an important therapeutic target in melanoma. We have designed inhibitors of...

Certain N-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives have been synthesized and evaluated in vitro for their antiproliferative activities against a panel of human cancer cell lines including nasopharyngea...

We aimed to develop a non-toxic and simple recovery procedure for poly(3-hydroxybutyrate) based on the use of green solvent. In this study, 2-methyltetrahydrofuran, 1,3-propanediol, 1,3-dioxolane and ethyl lactate were investigated and compared with chloroform in the extraction of poly(3-hydroxy...

The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe–S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly. The effect of deleting IBA57 in Saccharomyces cerevisiae on mitochondrial respiratory complex integration and functionality associated wit...

Sterically hindered diarylsilanes have been prepared by two synthetic routes. Dimesitylsilane, Mes2SiH2 (1), (Mes = 2,4,6-trimethylphenyl) was synthesized by reaction of mesityl magnesium bromide with HSiCl3 followed by reduction with LiAlH4, or by reaction of mesityl magnesium bromide with (TfO...

The photochemistry (direct irradiation in solution, λ>300nm) of the title compound (8) has been investigated. Whereas, in contrast to the methyl-free analog of 8, only undefined material of higher molecular weight was obtained upon irradiation without additives in acetonitrile and toluene, this...

Rat hepatic cytochrome P450 (P450) isozymes 1A1, 2C6, 2C11, 3A1 and 3A2 are targets for mechanism-based inactivation by the porphyrinogenic compound 3,5-diethoxycarbonyl-1,4-dihydro-2, 6-dimethyl-4-ethylpyridine (4-ethyl DDC). It is of interest to determine whether similar P450 isozymes are targ...