Oral absorption of protein/peptide-loaded nanoparticles is often limited by multiple barriers of the intestinal epithelium. In addition to mucus translocation and apical endocytosis, highly efficient transepithelial absorption of nanoparticles requires successful intracellular trafficking, espec...
In this research, hybrid organic-inorganic silica films were applied on the pre-treated AZ91 magnesium alloy by using the dip coating technique. Inorganic precursor, tetraethylorthosilicate (TEOS), and the organic silane, methyltriethoxysilane (MTES), were used for providing a hybrid sol-gel thi...
A convenient synthetic approach for previously unknown 1-chloro-2,2,2-trifluoroethyl isocyanate, based on reaction of easily accessible N-(2,2,2-trifluoroethyl-1-hydroxy)-O-ethylcarbamate with thionyl chloride and/or phosphorus pentachloride, was developed. The synthetic potential of the isocyan...
A facile method for the transition-metal-free diarylation of isocyanates with arynes in the presence of cesium fluoride has been developed, which affords functionalized diaryl amines in moderate to excellent yields. This reaction has good functional group tolerance and provides excellent regiose...
The countercurrent distribution behaviour of the rare-earth acetylacetonates in different solvent systems has been studied. Solubilities of the chelates in various solvents were determined in order to obtain data on the partition coefficients. The hydrated rare-earth acetylacetonates hydrolyze u...
New preparative methods have been developed and used to prepare several new rare earth acetylacetonate complexes. Crystalline forms of anhydrous neodymium and europium trisacetylacetonate and amorphous forms of anhydrous lanthanum, neodymium, samarium, europium, gadolinium and terbium trisacetyl...
The reaction of MCl2 · 2H2O (M = Cu, Zn) with 2,3,5,6-tetra(2-pyridyl)pyrazine (tppz) (referred hereafter as L) in 2:1 molar ratio in acetonitrile at room temperature afforded binuclear complexes [M2(κ3-L)Cl4] [Cu (1), Zn (2)] where the ligand is bis-tridentate manner. The complexes have been ...
The novel nanocomposites consisting of fluorinated polyimide (PI) films and zinc oxide (ZnO) nanoparticles, from which green light emission was observed, have successfully been prepared. The embedded ZnO nanoparticles in PI films were prepared by adding two separate zinc compounds in poly(amic a...
[2S-2-2H]- and [2R-2-2H]hexadecanoic acids were synthesized in overall yields of 59–67%. Methyl(2R)-2-hydroxyhexadecanoate, from the acid produced by Hansenula sydowiorum, was converted to the p-toluenesulphonate, reduced to trideutero alcohol with lithium aluminium deuteride and oxidized to [2...
ω-Fluoro-(ω−1)-hydroxy and ω-hydroxy-(ω−1)-fluoro fatty acid methyl esters with different length of the alkyl chain were synthesised by hydrofluorination of the corresponding epoxides. The phase behaviour of these fluorohydrins at the air–water interface has been investigated by film balanc...
Medium chain 2-hydroxy fatty acids and 3-hydroxy fatty acids (2-OH-FAs and 3-OH-FAs with 8–20 carbons) are widespread in nature but little was known about the quantities of these minor fatty acids in food. For this reason, the concentrations and composition of 2- and 3-OH-FAs in several foodstu...
The objective of this study was to investigate the effect of docosahexaenoic acid (DHA) supplementation on blood and intestinal DHA levels and lung function in mild/moderately affected adult CF patients with the ΔF508 genotype.
The phospholipid fatty acid composition of the Caribbean gorgonians Gorgonia mariae (Bayer) and Gorgonia ventalina (Linnaeus) is described for the first time. The main phospholipids identified were phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine. The main fatty acids were 1...
The phospholipid fatty acid composition of the Caribbean gorgonian corals Eunicea fusca (Duchassaing and Michelotti), Eunicea laciniata (Duchassaing and Michelotti), Eunicea mammosa (Lamouroux), Eunicea succinea (Pallas), and Eunicea sp. is described for the first time. The main phospholipids id...
Short and stereoselective syntheses of the two hydroxylated polyunsaturated fatty acid metabolites, namely 5-(S)-HETE and 5-(S)-HEPE, are reported in 23% and 30% overall yields, respectively. In addition, synthesis of the polyunsaturated fatty acid natural product (+)-zooxanthellactone has been ...
Starting from potent aldehyde inhibitors with poor drug properties, derivatization to semicarbazones led to the identification of a series of semicarbazone-based cathepsin K inhibitors with greater solubility and better pharmacokinetic profiles than their parent aldehydes. Furthermore, a represe...
During the course of our work on the synthesis and screening of new drugs for tuberculosis, we have identified N1-(4-acetamido phenyl)-N4-(2-nitro benzylidene) semicarbazone (1b), which inhibited in vitro Mycobacterium tuberculosis H37Rv; 100% inhibition at 1.56 μg/mL. This paper is first of it...
A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesul...
The title compounds 5-O-acetyl-1,2-anhydro-3-O-benzyl-α-d-ribofuranose and 5-O-acetyl-1,2-anhydro-3-O-benzyl-β-d-lyxofuranose, and 6-O-acetyl-1,2-anhydro-3,4-di-O-benzyl-α-d-glucopyranose and 6-O-acetyl-1,2-anhydro-3,4-di-O-benzyl-β-d-talopyranose, and 5-O-acetyl-1,2-anhydro-3,6-di-O-benzyl-...
1,3,4,6-Tetra-O-acetyl-2-deoxy-2-phthalimido-β-d-glucopyranose and 1,3,4,6-tetra-O-acetyl-2-deoxy-2-phthalimido-β-d-galactopyranose reacted with protected nucleosides in the presence of BF3 as promoter at room temperature to give selectively 2-amino-2-deoxy-β-glycosyl (1→5)nucleosides in goo...
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