A facile and robust microwave-assisted solution phase parallel synthesis protocol was exercised for the development of a 38-member library of N,N′-disubstituted thiourea analogues (1–38) by using an identical set of conditions. The reaction time for synthesis of N,N′-disubstituted thiourea an...
Thiourea derivatives (1–38) were synthesized and evaluated for their urease inhibition potential. The synthetic compounds showed a varying degree of in vitro urease inhibition with IC50 values 5.53 ± 0.02–91.50 ± 0.08 μM, most of which are superior to the standard thiourea (IC50 = 21.00 ± ...
A series of 1-((2-hydroxynaphthalen-1-yl)(phenyl)(methyl))pyrrolidin-2-one derivatives by an efficient iodine catalyzed domino reaction involving various aromatic aldehydes, 2-pyrrolidinone and β-naphthol was achieved and the structures were elucidated by FTIR 1H NMR, 13C NMR, and HRMS. Subsequ...
A series of regioisomerically monofluorinated 1-(naphthalen-1-yl)piperazines is described.
The regioselective ring opening halogenation of some epoxides using elemental iodine and bromine in the presence of a series of pyridine-containing groups has been studied. The epoxides were subject to cleavage by elemental halogen (I2 and Br2) in the presence of isonicotinic hydrazide (isoniazi...
Larvae of the leaf beetle Phaedon cochleariae synthesize the iridoid chysomelidial via the mevalonate pathway to repel predators. The normal terpenoid biosynthesis is integrated into the dedicated defensive pathway by the ω-hydroxylation of geraniol to (2E,6E)-2,6-dimethylocta-2,6-diene-1,8-dio...
Total resolution of the racemic cis- and trans-2-(4-methoxybenzyl)-1-cyclohexanols and 2-(4-methoxybenzyl)-1-cyclopentanols with Candida antarctica lipase B-catalysed transesterification was reached: high temperature (80-100 °C) and aw2000) of Novozym 435 towards the racemic molecules were obta...
The synthesis of 1-O-acetyl-3-O-(4-methoxybenzyl)-4-N-(9-fluorenylmethoxycarbonyl)-4-N-methyl-l-pyrrolosamine (7), which constitutes a protected form of the N,N-dimethyl-l-pyrrolosamine residues found within the antiproliferative bacterial metabolites (−)-lomaiviticins A and B (1 and 2, respecti...
Halide derivatives may be converted directly into their isothiocyanate homologues by the action of thicyanate ions fixed to the macromolecular network of an ion exchange resin. The reaction leads first to the thiocyanate derivative (kinetic product), which is isomerized to the isothiocyanate der...
The complexation in CDCl3 solution of rhodium(II) tetratrifluoroacetate Rh4TFA4 and tetraacetate Rh2AcO4 with ligands having nitrile, isonitrile, isothiocyanate and isocyanate functional groups has been investigated by means of 1H, 13C and 15N nuclear magnetic resonance (NMR) and absorption spec...
Isothiocyanates are electrophiles that are able to induce phase II biotransformation enzyme gene expression via an electrophile-responsive element (EpRE) in the gene regulatory region. To study the potency of different isothiocyanates to induce the expression of EpRE-regulated genes, a Hepa-1c1c...
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has roles in the innate immune response, and also contributes to inflammatory disease. While the biological properties of MIF are closely linked to protein–protein interactions, MIF also has tautomerase activity. Inhibi...
Aberrant activation of calpain has been observed in various pathophysiological disorders including neurodegenerative diseases such as Alzheimer’s Disease. Here we describe our efforts on ketoamide-based 1-benzyl-5-oxopyrrolidine-2-carboxamides as a novel series of highly selective calpain inhib...
In the present work, we synthesized three novel Cu(II) and Mn(II) complexes (1–3) of a tridentate Schiff base ligand (H2L1) derived from 2-hydroxy-4methoxybenzaldehyde and 2-amino benzyl alcohol. The Schiff base ligand and its complexes were characterized by FT-IR, UV–Vis and elemental analysi...
A new catalytic system for the anaerobic oxidation of benzyl alcohols using a tetrazole-amino-saccharin organocatalyst has been established. In a solvent-free and microwave assisted process comprising aqueous tert-butyl hydroperoxide (TBHP) as oxidant, a variety of benzyl alcohols has been effic...
A hitherto unknown, novel and direct approach to the efficient synthesis of N-benzyl-N-arylcyanamides is described via N-benzylation of a variety of arylcyanamides with benzyl bromide under ultrasound irradiation condition at room temperature; assorted N-benzyl-N-arylcyanamides are expeditiously...
The corrosion of steels in the supercritical CO2 environment with impurities in a carbon capture, utilization and storage system has attracted great interests in recent years. In this work, corrosion inhibition mechanisms of the residual 2-amino-2-methyl-1-propanol and piperazine from the CO2 ca...
In the past decade synthetic cathinones have appeared in drug markets worldwide. Chiral analysis can provide information on relative enantiomeric abundances of synthetic cathinones in their drug products, potentially giving a signature of these products and hence linking the products or excludin...
Selegiline hydrochloride (1-deprenyl) and bromocryptine mesylate (2-bromo-α-ergocryptine) are two drugs that have shown considerable promise in the treatment of Parkinson's disease. The in vivo mouse bone marrow micronucleus assay was used to examine their clastogenic and cytotoxic potenti...
α-Pyrrolidinoheptiophenone (PV8) is a representative of α-pyrrolidinophenone derivatives, a new group of synthetic cathinones. PV8 was first detected in illegal products in Japan in 2013. It is closely related to α-pyrrolidinovalerophenone (α-PVP), which was one of the most popular novel psy...
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View