The title molecule, N-(5-(4-methylbenzoyl)-2-oxo-4-(4-methylphenyl)pyrimidine-1(2H)-yl)-4-methylbenzamide (C27H23N3O3), was synthesized and characterized by elemental analysis, IR, Raman, 1H and 13C NMR spectral data. To determine conformational flexibility, potential energy surfaces of the titl...
The title compound was found to exhibit mechanochromic luminescence; the fluorescent color of the crystalline powder was changed from light blue to greenish yellow by grinding and then returned to the original by keeping at room temperature. The phenomenon was suggested to be due to formation of...
A recently identified organic nonlinear optical material, 4–Amino–(1–methylphenyl) pyridinium bromide (4A1MPB) was synthesized and attempts were made to grow good quality single crystal by slow evaporation solution growth technique which crystallizes in orthorhombic system with a non–centros...
A one-pot synthesis procedure was used for preparing two derivatives of chitosan bearing α-aminophosphonate moieties. Chitosan functionalization was performed by reacting chitosan with glutaraldehyde and triphenylphosphite or trimethylphosphite under selected experimental conditions. The materi...
Paper reports the synthesis and spectroscopic studies of two novel 1-Methyl-3-phenyl-1H-pyrazolo[3,4-b]quinoxaline (PQX) derivatives with 6-substituted methyl (MeMPPQX) or methoxy (MeOMPPQX) side groups. The optical absorption and fluorescence emission spectra are recorded in solvents of differe...
Reducing sugars have strong reactivity with 1-phenyl-3-methyl-5-pyrazolone (PMP) to form the sugar-PMP derivatives, which can be more accurately analyzed by HPLC-UV at 248 nm. Glucose and glucosamine reacted with the PMP based on the response surface methodology within a range of temperature bet...
D-amino acids (AA) analysis is becoming more and more relevant for metabolomics, therefore new analytical tools need to be developed. A common approach to achieve AA enantioseparation is chiral derivatization. Among the chiral derivatization reagents, (+) or (-)-1-(9-fluorenyl) ethyl chloroforma...
In the present study, a wide variety of 3-{[(1, 3-benzoxazol-2-yl) sulfanyl] (phenyl) methyl}-4‑hydroxy-2H-1-benzopyran-2-one derivatives were synthesized through one-pot three-component reaction using 4‑hydroxy coumarin, 2-mercapto benzoxazole and substituted aldehydes in presence of L-proline ...
Complexes of Cu(II), Ni(II), Co(II) and Fe(II) ions with N-[2-[(hydroxyalkylimino)methyl]phenyl]-4-methylbenzenesulfonamides containing the (CH2)n-spacer of a variable length (n = 2–6) were synthesized by chemical and electrochemical methods. All the compounds were characterized by C, H and N e...
A facile and efficient synthesis of pyrazolo[3,4-b]pyridines, indeno[1,2-b]pyrazolo[4,3-e]pyridine and benzo[h]pyrazolo[3,4-b]quinoline derivatives from the reaction of α,β-unsaturated ketone and 3-amino-1-phenyl-1H-pyrazol-5(4H)-one under mild conditions was reported. This reaction could be o...
Highly selective synthesis of 2-oxazolidinone from CO2 and 2-aminoethanol in acetonitrile solvent was achieved over heterogeneous CeO2 catalyst. Yield of 2-oxazolidinone reached 97% at 97% 2-aminoethanol conversion with >99% 2-aminoethanol-based selectivity in the optimized reaction conditions. ...
Reaction of 4-isopropylamino-5-chloro-1,2-dithiole-3-ones 3 and S2Cl2 in acetonitrile gave selectively 3-oxo-bis[1,2]dithiolo[1,4]thiazine-5-thiones 1 by the addition of triethylamine and bis[1,2]dithiolo[1,4]thiazine-3,5-diones 5 under the action of formic acid. 3,5-Diones 5 were also obtained ...
A new synthetic strategy for preparation of a wide range of 6-amino-2,4,5-trimethylpyridin-3-ols from pyridoxine·HCl via a six-step sequence has been developed. This approach features an introduction of various amino groups to C(6)-position of 3-benzyloxy-6-bromo-2,4,5-trimethylpyridine (13), a...
Mitosis inhibitors are powerful anticancer drugs. Based on a novel anti-microtubule agent of 5-(4′-methoxy)anilino-4-hydroxy-8-nitroquinazoline, a series of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8- nitroquinazolines were designed and synthesized to investigate the effect of the substitut...
Cytotoxic effects on MDBK cells of various 3-substituted propylamines, including spermine and spermidine, were tested in culture in the presence of calf serum, and the possible mode of action was studied from the viewpoint of oxidative deamination leading to acrolein formation. The compounds wer...
In this study, as a bioisosteric alternative scaffold of the antiviral aryl diketoacids (ADKs), we used 5-hydroxychromone on which two arylmethyloxy substituents were installed. The 5-hydroxychromones (5b–5g) thus prepared showed anti-HCV activity and, depending on the aromatic substituents on ...
Gel-type and macroporous chloromethylated poly(styrene-divinylbenzene) have been functionalized with 2,6-diformylpyridine bis(2′-pyridylhydrazone) groups. The synthetic route involved stepwise chemical modification of the polymer support. Polymer-bound 2,6-dimethoxycarbonylpyridine was converte...
Five novel 1H-pyrrolo[2,3-b]pyridine or 1H-pyrazolo[3,4-b]pyridine derivatives, with a methylene, sulfur, sulfoxide or cyclopropyl group as a linker, were designed, synthesized and biologically evaluated against c-Met and ALK. The development of these methods of compound synthesis may provide an...
A highly efficient cascade sequence for syntheses of 2,3-disubstituted imidazo[1,2-a]pyridines with exclusive regioselectivity in moderate to excellent yields has been developed. This cascade was initiated through propargylation of 2-aminopyridines at pyridine-nitrogen with propargyl alcohol der...
The applications of pyridines and their benzo derivatives, during the last decade are described together with natural products containing pyridine ring systems. The applications are classified into three categories: biological, chemical, and performance. Performance applications based on physica...
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