We report herein the design and synthesis of “novel imidazo [1,2-a]pyridine-3-carboxamides (IPAs)” bearing a variety of different linkers, based on the structure of IMB-1402 discovered in our lab. Results reveal that 2,6-dimethyl-N-[2-(phenylamino)ethyl] IPAs with an electron-donating group on...
Results of previous studies demonstrated that the tetraindole, SK228, which has a high lipid but low water solubility, displayed moderate anticancer efficacy in a xenograft model of breast cancer. This finding led to the proposal that new, pyridine based tetraindole (PBT) analogs of SK228, conta...
Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.
The reaction of 2,6-dimethoxypyridine-3-carboxylic acid (DMPH) with different precursors [Ti(η5-C5H5)2Cl2], [Ti(η5-C5H4Me)2Cl2], [Ti(η5-C5H4SiMe3)(η5-C5H5)Cl2], [Ti(η5-C5Me5)Cl3], SnMe3Cl and GatBu3 yielded the complexes [Ti(η5-C5H5)2(DMP-κO)2] (1), [Ti(η5-C5H4Me)2(DMP-κO)2] (2), [Ti(η...
The present paper reports on spectroscopic investigation of copigmentation effect of sinapic acid on the malvin molecule. A reaction of copigmentation was investigated by the use of UV–Vis absorption spectra in the whole range of acidic and moderately acidic buffered aqueous solutions (pH range...
Oxidation potentials of caffeic and chlorogenic acids, and their co-pigments with an anthocyan molecule, malvin, were measured by cyclic voltamemetry. It was found that these acids show electrochemical activity in a wide range of pH values of the supporting electrolyte, and that they undergo a s...
It is demonstrated that complexation between the ferric cation and the Z-chalcone of the naturally occurring anthocyanin malvin takes place in acidic aqueous solutions. The flexible open cavity of the Z-chalcone best fits the steric and electronic requirements of the ferric ion in water.
The syntheses and structural characterizations of a series of novel ‘3+2’ and ‘2+2+1’ mixed-ligand complexes carrying 8-hydroxy-5-nitroquinoline (HL) as the bidentate N,O donor atom system are reported. Thus, one-pot reactions of [ReOCl3(PPh3)2] with dianionic tridentate ligands H2Ln (where ...
The FT-IR and FT–Raman spectra of 8-hydroxy-5-nitroquinoline have been recorded in the regions 4000–400 and 4000–100 cm−1, respectively. The spectra were interpreted in terms of fundamentals modes, combination and overtone bands. The normal coordinate analysis was carried out to confirm the p...
Four anthocyanins from Ajuga reptans flowers and its cell cultures were isolated, and a fifth was also characterized by HPLC-mass spectrometry. By means of chemical and spectroscopic analyses, their structures were identified as delphinidin 3-(p-coumaroyl-feruloyl)sophoroside-5-malonylglucoside,...
Triacylated peonidin 3-sophoroside-5-glucosides were isolated from the purple flowers of Moricandia ramburii Webb. (Family: Brassicaceae), and determined to be peonidin 3-O-[2-O-(2-O-(trans-feruloyl)-glucosyl)-6-O-(trans-p-coumaroyl)-glucoside]-5-O-[6-O-(malonyl)-glucoside] (1), peonidin 3-O-[2-...
The structures of 11 acylated cyanidin 3-sophoroside-5-glucosides (pigments 1–11), isolated from the flowers of Iberis umbellata cultivars (Cruciferae), were elucidated by chemical and spectroscopic methods. Pigments 1–11 were acylated with malonic acid, p-coumaric acid, ferulic acid, sinapic ...
A novel tetra-acylated cyanidin 3-sophoroside-5-glucoside was isolated from the purple-violet flowers of Moricandia arvensis (L.) DC. (Family: Brassicaceae), and determined to be cyanidin 3-O-[2-O-(2-O-(4-O-(6-O-(4-O-(β-glucopyranosyl)-trans-caffeoyl)-β-glucopyranosyl)-trans-caffeoyl)-β-gluco...
Two novel acylated cyanidin 3-sophoroside-5-glucosides were isolated from the purple flowers of Raphanus sativus L. var. raphanistroides Makino (Family: Brassicaceae). Chemical and spectroscopic methods revealed that they were cyanidin 3-O-[2-O-(2-O-(trans-caffeoyl)-β-glucopyranosyl)-6-O-(trans...
(Z)-2-chloro-1,2-difluoro-1-iodoethene and (E)-2-chloro-1,2-difluoro-1-iodoethene successfully form stable zinc reagents. The zinc reagents successfully undergo Negishi coupling reactions with substituted aryl iodides to form (E)- and (Z)-1-chloro-1,2-difluorostyrenes.
Various 2-arylhydrazono-4-chloro-3-oxobutanoates 10a-i synthesized by the reaction of ethyl 4-chloro-3-oxobutanoate with the 4-substituted benzenediazonium chlorides were found to exist as two isomers between the (E)- and (Z)-hydrazone forms in DMSO-d6 solution. The equilibrium constants {K = [(...
Biofilms are a problem to food industries, causing equipment damage, increased energy costs, and food spoilage, and they are a potential harbour of pathogenic microorganisms. Their extreme antimicrobial resistance means that novel control strategies are necessary. Plant secondary metabolites (ph...
Long-chain n-alkyl terminated hydroxamic acids (HA) are used for the modification of titanium aluminum nitride (TiAlN) surfaces. HA coatings improve the hydrophobicity of this wear resistant and industrially relevant ceramic. Therefore, HAs with different structural properties are evaluated with...
A carbon paste electrode spiked with ferrocene carboxylic acid (FCAMCPE) was constructed by incorporation of ferrocene carboxylic acid in a graphite powder–paraffin oil matrix. It has been shown by direct current cyclic voltammetry and double step chronoamperometry that this electrode can catal...
A novel esterase, rPPE01, from Pseudomonas putida ECU1011 was heterologously expressed in Escherichia coli and identified for enzymatic resolution of hydroxy acids via O-deacetylation. α-Acetoxy carboxylates were converted with approximately 50% yield and excellent enantioselectivity (E > 200) ...
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View