A series of heteroaryl substituted bithiophene azo dyes in solution were irradiated with visible light to promote the azo E–Z isomerization and then the kinetics of the thermal Z–E back reaction was studied. The speed of this process is strongly influenced by the nature of the aromatic ring li...
A feed-forward artificial neural network (ANN) learned by error back-propagation is used to generate a retention predictive model for phenoxy acid herbicides in isocratic reversed-phase high-performance liquid chromatography. The investigated solutes (18 compounds), apart from the most common he...
To understand the role of abundance of tfdA gene classes belonging to β- and γ-proteobacteria on phenoxy acid herbicide degradation, streambed sediments were sampled around three seepage meters (SMs) installed in a landfill-impacted groundwater–surface water interface. Highest herbicide mass ...
A novel yellow organic emitter, namely 2,2′,2″-nitrilotris(anthracene-9,10-dione) (NAQ3), is feasibly synthesized through one-step Buchwald-Hartiwig C-N couple reaction between 2-aminoanthracene-9,10-dione and 2-bromoanthracene-9,10-dione. The opto-electronic properties of NAQ3 are fully studi...
ObjectiveTo assess whether vitamin D supplementation could be associated with a modification of inflammatory markers and bone turnover in HIV-1-infected patients.
Background & aimsVitamin D and parathormone (PTH) have been associated with cardiovascular outcomes, but their impact on atrial fibrillation (AF) onset is still unclear. We explored the influence of serum 25-hydroxyvitamin D (25[OH]D) and PTH on AF risk in older adults.
PurposeStudies suggest that vitamin D supplementation improves myelination and recovery after nerve injuries. The purpose of this study was to evaluate whether correction of vitamin D level leads to better surgical outcomes in women with both carpal tunnel syndrome (CTS) and vitamin D deficiency.
The cytochrome d-containing oxidase of oxygen-limited Escherichia coli comprises cytochromes d, cytochrome b-558 and cytochrome b-595, previously called cytochrome a1. The reaction of the fully reduced complex with oxygen involves ligand binding to the ferrous haem d to form an oxygenated specie...
ObjectiveTo identify medications that may prevent psychosis in patients with Alzheimer disease (AD).
Various populations are at increased risk of developing a low vitamin D status, in particular older adults. Whereas sun exposure is considered the main source of vitamin D, especially during summer, dietary contributions should not be underestimated. This study aims to identify food sources of v...
BackgroundElectrical burns are important causes of trauma worldwide. This study aims to analyze the clinical characteristics, wound management, and outcome of electric burns.
An aluminum material stabilized with a 1.6 vol% of nanometric Al2O3 dispersoids, named HITEMAL, was fabricated by hot extrusion of a fine atomized Al powder. The Al2O3 dispersoids stemmed from a native Al2O3 films on an aluminum powder surface. An extruded rod of the material was then cold-defor...
Increasing evidence indicated that dysregulation of microRNAs (miRNAs) were involved with human disease including cancer. Recently, miR-595 was reported as a tumor promoter in malignant mesothelioma. However, the underlying mechanism of miR-595 in human glioblastoma (GBM) cells have not been wel...
3-D-Quantitative structure–activity relationships of N-(3-acyloxy-2-benzylpropyl)-N′-dihydroxytetrahydro-benzazepine and tetrahydroisoquinoline and N-(3-acyloxy-2-benzylpropyl)-N′-(4-hydroxy-3-methoxybenzyl) thiourea analogues as potent vanilloid receptor ligands were investigated using the C...
The vanilloid receptor represents a promising target for drug development. Building on our previous strategies which have generated potent agonists for VR1, we now describe a series of novel N-(3-acyloxy-2-benzylpropyl)-N′-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analo...
We recently reported that N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea (2) was a high affinity antagonist of the vanilloid receptor with a binding affinity of Ki=63 nM and an antagonism of Ki=53.9 nM in rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells (Mo...
In a continuing effort to elucidate the structure–activity relationships of the lead antagonist N-[2-(3,4-dimethylbenzyl)-3-pivaloyloxypropyl]-N′-[4-(methylsulfonylamino)benzyl]thiourea (1), the distances between the proposed four pharmacophores in 1 have been varied by insertion or deletion o...
Unavailability of vaccine and satisfactory drug regimen has made Hepatitis C a worldwide health issue which needs to be urgently addressed. In the present study, diverse classification models have been developed for anti-Hepatitis C virus (HCV) activity of thiourea derivatives. Values of various...
Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3,4-dimethylphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (C5) displayed the most potent EGFR in...
A series of inhibitors of 20S proteasome based on terminal functionalized dipeptide derivatives containing the thiourea moiety were synthesized and evaluated for inhibition of 20S proteasome and the effects of multidrug-resistance reversers. These compounds exhibited significant selectivity to t...
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