Reactions of [(η5-R)Rh(CO)2] (R = cp, ind) with water-soluble phosphines (L = 1,3,5-triaza-7-phosphaadamantane and tris(2-cyanoethyl)phosphine) give the new rhodium(I) complexes of the types [Rh(η5-cp)(CO)(PTA)] (1), [Rh(η5-cp)(CO)(P(CH2CH2CN)3)] (2), [Rh(η5-ind)(CO)(PTA)] (3) and [Rh(η5-in...
In this Letter, a facile method for the synthesis of 2′-O-cyanoethyluridine, which is a key intermediate in the synthesis of fully and partially 2′-O-cyanoethylated oligoribonucleotides as well as unmodified oligoribonucleotides, was developed by the ring-opening reaction of 2,2′-anhydrouridi...
Aminothiol levels are indicative of cellular and physiological statuses. A colorimetric and ratiometric dual-site fluorescent probe, NL-S, has been designed and synthesized. NL-S contains both a 2,4-dinitrobenzenesulfonyl group and an aldehyde group as recognition units for aminothiols. NL-S exh...
The tin(II) bromide-catalyzed reaction of diazo[bis(4-methoxyphenyl)]methane with racemic propane-1,2-diol in 1,2-dimethoxymethane resulted in the highly regioselective etherification of the primary hydroxyl group. After tritylation of the minor 2-ether, 1-[bis(4-methoxyphenyl)]methoxypropane-2-...
In a cheap and eco-friendly process, primary and secondary alcohols were easily protected as bis(methoxyphenyl)methyl (BMPM) ethers in good yields using CuBr2 as a catalyst in acetonitrile at room temperature. Deprotection could easily be achieved using the same catalyst but in ethanol. Both Cu-...
2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 KATP channels of beta cells.
The synthesis and evaluation of the biological activity of new 4-chloro-5-{4-[2-(2-methoxyphenoxy)-ethyl]-1-piperazinyl}-3(2H)-pyridazinone derivatives are reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoceptors of isolated rat vas deferens.
Primary and secondary silylated alcohols are easily converted to bis(methoxyphenyl)methyl (BMPM) ethers in good yields using CuBr2 as catalyst in acetonitrile at room temperature. Various other protecting groups are compatible with this mild and convenient process.
We report the efficient combination of SNAr and organic Brønsted acid catalysis protocols for the construction of cis-aziridine-derived biaryl and triaryl ethers. Using aza-Darzens chemistry mono-cis-aziridine-biaryl and bis-(cis-aziridine)-triaryl ethers have been generated; these motifs have s...
A few new α- and β-d-galactopyranoside-based chiral lariat ethers of monoaza-15-crown-5 type were synthesized. These macrocycles proved to be efficient catalysts in a few asymmetric reactions under mild phase transfer conditions. The catalytic effect of the lariat ethers with methoxy, ethoxy, ...
The reaction of N-(2,4-dinitrophenyl)pyridinium chloride (salt(Cl−)) with lithium bis(trifluoromethanesulfonyl)imide (TFSI−LI+) and lithium bis(nonafluorobutanesulfonyl)imide (NFSI−LI+) resulted in the anion exchange between Cl− and TFSI− and Cl− and NFSI− that yielded new Zincke salts, namely s...
The collisionally activated mass spectral fragmentations of N-(2,4-dinitrophenyl)alanine and phenylalanine [M - H]− may be gas-phase analogs of the base-catalyzed cyclization of N-(2,4-dinitrophenyl)amino acids in aqueous dioxane. This latter reaction is one source of the 2-substituted 5-nitro-1...
The kinetics of the hydrolysis of bis(2,4-dinitrophenyl) phosphate (BDNPP) has been studied in the presence of a dinuclear Fe(III) complex that acts as a catalyst in the hydrolytic reaction. One equivalent of the 2,4-dinitrophenolate ion (DNP) and one equivalent of 2,4-dinitrophenylphosphate (DN...
We have developed a spectrophotometric assay for phospholipase A2 activity using 2,4-dinitrophenyl-labeled phosphatidylcholine as substrate. The assay allows quite simple quantification of phospholipase A2 activity by measuring the absorbance of the aqueous phase after extraction of the reaction...
The preparation of N2-phenoxylacetyl-S6-(2,4-dinitrophenyl)-6-thioguanosine phosphoramidite and its subsequent incorporation into oligoribonucleotides is described. The identity of the oligonucleotides was confirmed by UV spectrophotometry and nucleoside composition analysis.
A series of O2-(2,4-dinitrophenyl)diazeniumdiolates derivatives were designed, synthesized and antiproliferative activities evaluated as novel nitric oxide (NO)-releasing prodrugs that could be activated by glutathione S-transferases π (GSTπ). Most of these derivatives exhibited significant an...
N-Benzyloxycarbony-S-(2,4-dinitrophenyl)glutathione diesters have been investigated for antimalarial activity against chloroquinine sensitive (NF54) and resistant (K1) strains of P. falciparum. Both strains appear equally susceptible to inhibition by compounds 1–4, with an IC50 ∼ 4.92–6.97 μ...
Differences in the stoichiometry of ligand binding were observed between chicken IgG and rabbit IgG anti-2,4 dinitrophenyl antibodies elicited by the same immunogen and purified by identical procedures. Equilibrium dialysis binding studies revealed the ability of chiken IgG antibody to bind more...
In the present integrated experimental/theoretical work, the synergistic inhibition effects of aminotris methylene phosphonic acid (ATMP) and Zn ions for steel corrosion mitigation in NaCl solution were examined. The inhibition property of ATMP:Zn mixture was evaluated by electrochemical approac...
A multiple heartcut (MHC) 2D-UHPLC method with UV detection has been developed for the enantioselective analysis of complex amino acid mixtures in a single run. The MHC method is based on an achiral gradient RPLC separation with 1.8 μm C18 phase (100 × 2.1 mm ID column) in the first dimension ...
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