As an extension of our project aimed at the search for new chemotherapeutic agents against Chagas disease and toxoplasmosis, several 1,1-bisphosphonates were designed, synthesized and biologically evaluated against Trypanosoma cruzi and Toxoplasma gondii, the etiologic agents of these diseases, ...

To accurately predict the seasonal fluctuations of the electricity consumption of the primary economic sectors, we propose a seasonal grey model (SGM(1,1) model) based on the accumulation operators generated by seasonal factors. We use the proposed model to carry out an empirical analysis based ...

Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves CH functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonamide. This functional group tolerant approac...

Formyloxyacetoxyphenylmethane, symmetric 1,1-diacylals and mixed 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as moisture stable O-formylating and O-acylating reagents for primary and secondary alcohols, allylic alcohols and phenols under solvent/catalyst free conditions to afford their ...

An efficient method for the preparation of 2,2-diarylvinyl halides from the corresponding 1,1-diarylethylenes has been developed. N-Halosuccinimides (N-bromosuccinimide or N-chlorosuccinimide) were used as the halogenation reagents. The practicability of this method is highlighted by its simple ...

The introduction of fluorine atoms into an organic molecule has become an important research field since fluorinated compounds play crucial roles in life science and materials chemistry. Among various fluorinated moieties, the difluoroethyl group (CF2CH3) mimics the steric and electronic feature...

An interesting protocol for the synthesis of benzothiadiazine-1,1-dioxides through iodine-catalyzed one-pot dehomologative oxidation of styrenes and readily available 2-aminobenzenesulfonamide has been developed. Diverse benzothiadiazine-1,1-dioxides were prepared using I2 as a catalyst, TBHP as...

2,3,5-Triphenyl-2H-tetrazolium chloride (TPT) has been proposed as a redox indicator for determination of 1,1-dimethylhydrazine (DMH) which is used as a rocket propellant. It has been found that TPT is a sensitive chromogenic reagent due to its potentiometric and spectral characteristics. Produc...

The C≡C bonds of various alkynylgermanes [Cl(H)Ge(C≡C–R1)2, Cl2Ge(C≡C–R1)2 with R1 = nBu, SiMe3, and Ge(C≡C–R1)4 with R1 = SiMe3] undergo 1,1-carboboration when treated with an excess of triethylborane at 80–110 °C. All pure final products with R1 = SiMe3 possess germole-derived structu...

An almost quantitative synthesis of N-methyl-2-anilino-6-naphthalenesulfonyl hydrazine (2,6-mansyl hydrazine) from sulfonyl chloride and hydrazinlum hydroxide is described. The 2,6-mansyl chloride was prepared by different methods from 6-hydroxynaphthalene-2-sulfonic acid (overall yield: 69%). T...

Bond angles at thiohydroxamate oxygen in crystal structures of 3-alkoxy-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thiones gradually increased with the size of the 3-alkoxy substituent. This effect was attributed to strain on the basis of (i) a linear free energy relationship (Taft–Dubois corre...

The imidazolium salts 1,1′-dibenzyl-3,3′-propylenediimidazolium dichloride and 1,1′-bis(1-naphthalenemethyl)-3,3′-propylenediimidazolium dichloride have been synthesized and transformed into the corresponding bis(NHC) ligands 1,1′-dibenzyl-3,3′-propylenediimidazol-2-ylidene (L1) and 1,1′-...

Inflammation plays a central role in the pathophysiology of many diseases. The inducible enzyme heme oxygenase-1 (HO-1) protects cells against inflammation and can be induced by electrophilic compounds like the chalcones (1,3-diphenylprop-2-enones) from the class of α,β-unsaturated carbonyl co...

Five coordination polymers bearing 2-p-methoxyphenyl-1H-imidazole-4,5-dicarboxylic acid (H3MOPhIDC) formulated as [Zn2(μ2-HMOPhIDC)2(phen)2]n (phen = 1,10-phenanthroline) (1), [X(μ2-HMOPhIDC)(2,2’-bipy)]n (X = Ni (2) and Mn (3), 2,2′-bipy = 2,2′-bipyridine) and {[M(μ2-H2MOPhIDC)2]·2H2O}n ...

Photo-doping is a process to optimize solid-state dye-sensitized solar cells based on 2,2′7,7′-tetrakis-(N,N-di-p-methoxyphenyl-amine)-9,9′-spirobifluorene (spiro-OMeTAD). We investigate the effect of photo-doping on performance for solid-state DSSC based on spiro-OMeTAD and carbon counter el...

Oxidation of the β-substituted highly enantioenriched aldehydes obtained by hydrolysis of the 3,3-disubstituted enecarbamates affords enantioenriched β-substituted acids and esters. Lithiation of enantioenriched 3,3-disubstituted enecarbamates and subsequent reaction with electrophiles provide...

Five coordination compounds Zn(mbmpbi)2Cl2 (1), Zn(mbmpbi)2Br2 (2), Cd(mbmpbi)2Cl2 (3), Hg(mbmpbi)2Cl2 (4) and Hg(mbmpbi)2Br2 (5) were synthesized by the reaction of 1-(p-methoxybenzyl)-2-(p-methoxyphenyl)benzimidazole (mbmpbi) with the corresponding metal halides. The complexes have been charac...

Mild and efficient procedures for deprotection of the amine nitrogen protecting p-methoxyphenyl (PMP) group are described. Periodic acid and trichloroisocyanuric acid (TCCA) were found to be particularly effective in realizing amine liberation using 1 and 0.5 equiv of the oxidant, respectively. ...

1-(4-Methoxyphenyl)-12-hydroxymethyl-p-carborane (2a), which is a precursor to the previously developed potent carborane-containing ER agonist BE120, exhibited weak cell growth inhibitory activity against four human cancer cell lines (MCF-7, MDA-MB-453, LNCaP, and PC-3). The biological evaluatio...

A novel series of 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives has been prepared and their synthesis described herein. In vitro affinities for δ-, μ-, and κ-opioid receptors, as well as the functional activity in the [35S]GTPγS assay are reported. The most potent and selective δ-opi...