Semiempirical quantum mechanical calculations, using the iterative extended Huckel theory, are carried out for the evaluation of conformational energies, dipole moment and net atomic charges as a function of the rotation about the glycosidic bond. Torsion about the C(4′)-C(5′) bond has also be...

1.1. Formycin triphosphate (FTP), a fluorescent analogue of ATP, is a substrate for (Na+ + K+)-ATPase (ATP phosphohydrolase, EC 3.6.1.3), with properties similar to those of ATP.2.2. FTP and formycin diphosphate (FDP) bind to the enzyme with high affinity and, on binding, the nucleotide fluoresc...

The modifications in ultraviolet absorption and fluorescence emission accompanying dephosphorylation of formycin 5′-phosphate may be employed for the continuous assay of 5′-nucleotidase (5′-ribonucleotide phosphohydrolase, EC 3.1.3.5) activity. The sensitivity of the fluorimetric method is ad...

Formycin B, a pyrazolo(4,3-d)pyrimidine C-nucleoside, inhibited the growth of Leishmaniadonovani promastigotes in culture with an ED90 of 0.2 μg/ml. Promastigotes incubated for 24 hrs with Formycin B at 10 μg/ml were found to convert it to the ribonucleotide, formycin B 5′-monophosphate. The ...

The ADP/ATP carrier was studied by a fluorescent substrate, formycin diphosphate which is the only fluorescent ADP analogue to bind. Its low quantum yield, short decay time and spectral overlap with tryptophan has as yet prevented its wider use.By incorporating fluorescent acceptors of formycin ...

An INDO study has shown that the title compound exists in two diastereomeric propeller-like conformations, a cis form (C3 symmetry), and a trans form (C1 symmetry). The cis form is more stable than the trans form by 0·75 kcal/mole. The two forms undergo ready conformational interconversion by t...

The facilitating or antagonizing effects of polyamine analogues on N-methyl-dl-aspartate (NMDLA)-induced seizures were investigated using mice. Intracerebroventricular injection of spermidine and spermine, but not putrescine, shortened the latency to appearance of clonic convulsion induced by su...

Binding of [3H] N-[1-(2-thienyl)cyclohexyl]piperidine was examined using rat brain synaptic membranes treated with a low concentration of Triton X-100. This compound is assumed to be a non-competitive antagonist for the N-methyl-d-aspartate(NMDA)-sensitive subclass of central excitatory amino ac...

5-(2-Thienyl)valeric acid (TVA), a biotin analogue which can be easily prepared through chemical process, inhibited the growth of a biotin synthesizing Rhodotorula glutinis. The growth inhibition was reversed by the addition of biotin. Among biotin intermediates, dethiobiotin and 7,8-diaminopela...

SummaryPolarographic investigations on substituted styryl-α-thienyl ketones have been carried out. In 50% aqueous-ethanolic buffered media, the unsubstituted compound viz. 1-(2-thienyl)-3-phenyl-2-propenone gave two one-electron reduction waves in acidic solutions, and an additional third two-e...

The syntheses and multinuclear NMR and IR spectroscopic characterizations of some mononuclear Mo, Pd and Pt complexes of acetyldiphenylphosphine, diphenyl(2-thienyl)phosphine, bis(2-thienyl)phenylphosphine and cyanodiphenylphosphine are presented. The NMR and IR spectra of the Mo carbonyl comple...

Poly(2,5-di-(2-thienyl)-furan) (PSOS) was synthesized via anodic polymerization of 2,5-di-(2-thienyl)-furan (SOS) in ethanol solution containing 0.2 M LiClO4 as supporting electrolyte. The electrochemical and spectroelectrochemical properties were investigated using electroanalytical and UV–vis...

Poly (4-(2-Thienyl) benzenamine) (PTBA) and corresponding homopolymers doped with sodium dodecyl benzene sulfonate (SDBS) and dedoped polymer coatings on steel surface have been synthesized by galvanostatic method. The anticorrosion performances of PTBA and its homopolymers coatings were investi...

As part of our study on oxomolybdenum(V) complexes we present here the synthesis and crystal structure of a novel dimeric oxomolybdate(V) [Mo2O4(acac)2thala]·3C2H5OH (acac=acetylacetonato, thala=3-(2-thienyl)-dl-alanine) in which two molybdenum atoms are being bridged not only by two oxo-oxygen...

4-(2-Thienyl)benzenamine (TBA) was successfully synthesized by a simple method including substitution of thiophene on p-nitroaniline followed by reduction of nitro group. Structure of the synthesized monomer was verified using IR, 1H NMR, GC–MS and elemental analysis techniques. Corresponding p...

The enantiomers of methyl (E)-2,4,5-tetradecatrienoate (1), a component of the male pheromone of Acanthoscelides obtectus, were synthesized from the enantiomers of 1-undecyn-3-ol (6), which were obtained via asymmetric acetylation of (±)-1-trimethylsilyl-1-undecyn-3-ol (4) with vinyl acetate as...

In this paper the synthesis, optimisation and application of a silane based monolithic copolymer for the rapid separation of proteins and oligonucleotides is described. The monolith was prepared by thermal initiated in situ copolymerisation of trimethylsilyl-4-methylstyrene (TMSiMS) and bis(4-vi...

1-Methoxy-2-propanol (M2P) is finding increasing industrial use as a less toxic alternative to the short-chained ethylene glycol ethers. Like most glycol ethers, M2P is readily absorbed through the skin and biological monitoring is therefore appropriate in assessing occupational exposure. An ana...

A new protecting group for alcohols, the p-trimethylsilyl xylyl (TIX) group has been developed. The TIX group is used to protect various alcohols under acidic as well as basic conditions. The protected ethers thus formed had noteworthy chemoselectivity upon deprotection in the presence of other ...

A series of four trimethylsilyl group containing copolymers were synthesized using the solution free-radical copolymerization with azobisisobutyronitrile (AIBN) in 1,4-dioxane at 60 °C. The photoresists were prepared by dissolving copolymer, one of two kind photosensitizer (dimethylaminoethyl m...