Synthetic methods for phosphoryl compounds are described. The methods cover 75 classes of compounds. These include dialkyl/diaryl phosphoryl substances of general structure: ROP(O)Cl2, ArOP(O)Cl2, ROP(O)F2, ArOP(O)F2, ROP(O)(NR2)2, ROP(O)(NHNHR)2, ROP(O)(NCO)2, ROP(O)(NCS)2, ROP(O)(OH)2, ROP(O)(...

Bis(9-fluorenylmethyl)phosphite (BFMP) was found to be an effective reagent for the N-phosphorylation of various amino acid methyl esters. BFMP was prepared from N,N-diisopropyl phosphoramidous dichloride in a one-pot two-step reaction and was obtained as a crystalline solid. N-Phosphorylation o...

The reactions of four different N-(O,O′-diisopropyl) phosphoamino acids (DIPP-aa), such as N-phosphoryl-l-α-alanine (DIPP-l-α-Ala), N-phosphoryl-d-α-alanine (DIPP-d-α-Ala), N-phosphoryl-β-alanine (DIPP-β-Ala) and N-phosphoryl-γ-amino butyric acid (DIPP-γ-Aba), and four nucleosides, aden...

Stable isotope chemical labeling liquid chromatography-mass spectrometry (LC-MS) is a powerful strategy for comprehensive metabolomics profiling, which can improve metabolites coverage and quantitative information for exploration of metabolic regulation in complex biological systems. In the curr...

The synthesis of N-(O,O-diisopropyl phosphoryl)-benzyltetrahydroisoquinoline (3) has been achieved in a ‘one pot' procedure from imine (2) and diisopropyl-phosphorochloridate (1) generated in situ (POCl3+iPrOH). Compound 3 is the first benzyltetrahydroisoquinoline derivative found to be a ...

It was found that Nα,Nɛ-di[N-(O,O-diisopropyl)phosphoryl-l-leucy]-l-lysyl-methyl ester (1) and Nα,Nɛ-di[N-(O,O-diisopropyl)phosphoryl-l-phenylalanyl]-l-lysyl-methyl ester (2) could cleave supercoiled DNA such as PUC19 efficiently in 40 mM Britton-Robinson buffer. The cleavage activities for bo...

N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.

An approach to 1-hetaryl-2,2-difluorocyclopropane building blocks compatible with the current criteria of lead-oriented synthesis was developed and implemented for the case of 3-, 4- and 5-subsituted pyrazole derivatives. The method implied 6–9 synthetic steps, including difluorocyclopropanatio...

2-(2-Chloro-6-fluorophenyl)acetamides having 2,2-difluoro-2-aryl/heteroaryl-ethylamine P3 and oxyguanidine P1 substituents are potent thrombin inhibitors (Ki = 0.9–33.9 nM). 2-(5-Chloro-pyridin-2-yl)-2,2-difluoroethylamine was the best P3 substituent, yielding the most potent inhibitor (Ki = 0....

A new symmetrical phenylpropanoid glycoside, tangshenoside VIII (1), together with six known tangshenosides (2–7) were isolated from the roots of Codonopsis lanceolata (Campanulaceae). Their structures were established on the basis of spectroscopic data, including two-dimensional NMR analyses. ...

Block copolymers represent an interesting class of materials, combining properties of individual components and capable of developing nanoscopic domain morphologies. Copolymers which comprise polystyrene and poly(dimethylsiloxane) attract special attention due to their effective segregation and ...

The addition of block copolymers (i.e. oils) is a common technique to enhance the biofouling-resistance properties of poly(dimethylsiloxane) (PDMS)-based fouling-release coatings. These copolymers diffuse from the bulk to the surface of the coating, thus modifying the properties of the surface a...

Creating inorganic nanostructures for development of nanoelectronic device components is a highly active research area. The ability for manipulation of the chemistry of materials, as well as their shape, size and placement enables scientists and engineers to propose technologically advanced devi...

A novel route for a preparation of polystyrene-block-poly(ethylene oxide) (PS-b-PEO) block copolymer vesicles induced by supercritical carbon dioxide (scCO2) is demonstrated. When PS-b-PEO block copolymer solutions in tetrahydrofuran (THF) are treated with scCO2 at 70 °C for different times, PS...

This comprehensive review, summarizes recent advances in the fabrication of well-ordered block copolymer (BCP) thin films by different methods, focusing on the development of silicon-containing BCPs as candidates for lithographic applications. With the advantage of Si-containing blocks, these BC...

The Dissipative Particle Dynamics (DPD) simulation technique was used to elucidate the composition-dependent equilibrium morphological behavior of three different symmetric ABA triblock copolymers, which were; poly(ε-caprolactone)-poly(dimethylsiloxane)-poly(ε-caprolactone) (PCL-PDMS-PCL), pol...

The structure, morphology and final properties of synthesized waterborne poly(urethane-urea)s (WPUU) based on triblock copolymers containing hydrophilic poly(ethylene oxide) PEO block as polyol has been studied. Different molecular weight poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (...

A diblock copolymer poly(3-hexylthiophene)-block-poly(dimethylsiloxane) (P3HT-b-PDMS) was synthesized as a donor material for organic photovoltaic devices. The regioregular poly(3-hexylthiophene) (P3HT) with a bromo-terminal was prepared via Grignard metathesis polymerization, and poly(dimethyls...

Polysulfone poly(alkylene oxide)-poly(dimethylsiloxane) block copolymers have been prepared by the hydrosilylation reaction of allyl endcapped poly[(ethylene oxide) (propylene oxide)] oligomers with Si–H terminated polydimethylsiloxane in chlorobenzene using an isopropanol solution of hexachlor...

The phase behavior of triblock and graft-type poly(dimethylsiloxane) (PDMS)–poly(ethylene oxide) (PEO) copolymer surfactants has been investigated in compressed carbon dioxide (CO2). For this purpose, cloud-point pressures have been measured in the pressure and temperature range from P = 10 to ...