This study investigated the potential of vitamin K1 against streptozotocin-induced diabetic cataract in Wistar rats. A single, intraperitoneal injection of streptozotocin (STZ) (35 mg/kg) resulted in hyperglycemia, accumulation of sorbitol and formation of advanced glycation end product (AGE) in...

The 2-C-methyl-d-erythritol-4-phosphate and shikimate pathways were found to be active in Plasmodium falciparum and both can result in vitamin E biosynthesis in plants and algae. This study biochemically confirmed vitamin E biosynthesis in the malaria parasite, which can be inhibited by usnic ac...

This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, “oncogenic” and “onco-suppressive” reactive oxygen species and the specific induction ...

Perchlorate is not only a known health hazard for human but also one of the persistent inorganic pollutants. Some significant technologies have been carried out to remove or reduce perchlorate in water. A comprehensive review about these technologies is presented, including adsorption, membrane ...

Perchlorate permselective membranes were synthesized and characterized in this study. The membrane with a thickness of ~300 μm was prepared with polyvinyl chloride (PVC) and quaternary ammonium salts in solvent under room temperature. Among the 12 different quaternary ammonium salts, methyltrib...

There has been no reliable published data on the presence of perchlorate in seawater. Seaweeds are among the most important plant life in the ocean and are good sources of iodine and have been widely used as food and nutritional supplement. Perchlorate is known to inhibit the transport of iodide...

Benzaldehyde oxime can be readily converted to the corresponding benzaldehyde in high yields. The electrochemical oxidation was optimized with various experimental parameters to result in the high yield of benzaldehyde (80%). The reaction was carried out with platinum electrodes at room temperat...

A series of organo-montmorillonites (organo-Mt) was synthesized using various cationic surfactants with different alkyl-chain lengths, head groups, and alkyl-chain numbers, which were systematically examined for perchlorate adsorption. The products were characterized by the specific surface area...

Addition of trimethylammonium perchlorate to potassium perchlorate (KP) catalyzes its thermal decomposition. However, although the additive sensitises KP-PU propellant decomposition, its combustion is desensitised. The observed effects have been explained in terms of the role played by the early...

In order to investigate diffusion models and adsorption mechanism of polymeric ligand exchangers (PLE) for the removal of perchlorate from tap water Lewatit MonoPlus TP 220-Cu, Lewatit MonoPlus TP 220-CuEDDS, Dowex 4195-Cu and M 4195-CuEDDS were prepared and compared with commercial Lewatit TP 2...

A study of the burning rates of compressed mixtures of ammonium perchlorate (AP) and trimethylammonium perchlorate (TMAP) has been carried out at ambient pressure. The overall increase in the linear burning rate, showing a maximum at a composition having 80% TMAP, has been discussed in terms of ...

Two types of bovine pituitary gland polyprenols were resolved by silica gel chromatography; i. e., the high molecular weight dolichols of 17 to 23 isoprene units with the OH-terminal isoprene residue saturated, and a fully unsaturated decaprenol. The latter compound was found to be a mixture of ...

The effects of pizotifen on protein and carbohydrate self-selection in rats over a seven-day period, and on 5-HT turnover was studied. Four groups of male Wistar rats were individually caged and ad lib fed with a standard (SD) and (50%) carbohydrate-enriched diet (CED), sweet (diet group I) or n...

The affinity of pizotifen, ketotifen and other tricyclic antimuscarinic drugs for different muscarinic receptor subtypes was investigated in vitro in functional experiments with field-stimulated vas deferens of the rabbit (M1 and M2 receptors) and with ileum and trachea of the guinea-pig (M3 rec...

Internal and external carotid vascular resistances were measured, in anaesthetized monkeys, to assess the direct cranial vascular effects of i.v. methysergide, pizotifen and ergotamine, and their effects on the cranial vascular responses to the constrictors 5-hydroxytryptamine and noradrenaline ...

The serotonin antagonist pizotifen (BC-105) is prescribed as an appetite and weight enhancer (Mosegor®—Wander, also commercialized under brand names Sanmigran® or Sandomigran®—Sandoz, Switzerland) for anorectic and convalescent humans. There has been, however, diffuculty in demonstrating any o...

The affinities of cyproheptadine, pizotifen and (±)-quinuclidinyl xanthane-9-carboxylate hemioxylate (QNX) were determined at muscarinic autoreceptors and postsynaptic (IP1 formation) receptors in rat hippocampal slices. The affinity values for QNX were 8.2 and 8.5 respectively. Cyproheptadine ...

The aim of this study was to develop and evaluate a transdermal delivery system of pizotifen malate. Pizotifen is frequently used in the preventive treatment of migraine, but is also indicated in eating disorders.In the course of the project, the effects of chemical enhancers such as ethanol, 1,...

Two experiments were conducted to assess the effects of succinate and pH on cooked beef color. In experiment 1, ten strip loins (M. longissimus lumborum) were divided in half and assigned to either non-enhanced control or 2.5% succinate. Each half-loin was cut into steaks, packaged in vacuum or ...

2-ethyl-6-methyl-3-hydroxypyridine (EMHP) succinate is the original antioxidant and antihypoxic drug commonly prescribed in Russia. The objective of this study was to develop a rapid, simple and sensitive high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) method for EM...