Butyrate, a metabolite of gut flora-mediated fermentation of dietary fibre, was analysed for effects on expression of genes related to oxidative stress in primary human colon cells. An induction of detoxifying, antioxidative genes is expected to contribute to dietary chemoprevention. Cells were ...

The release of cholecystokinin (CCK) and dopamine (DA) was measured simultaneously in the medial frontal cortex of the rat using an in vivo microdialysis technique coupled to either enzyme immunoassay or high performance liquid chromatography with electrochemical detection method. Basal levels o...

Pulmonary edema (PE) caused by central nerve irritation is a known clinical condition. Our study was undertaken in order to investigate the mechanism of this condition. PE was induced in 29 dogs by a standard technique of intradsteraal veratrine. The standard method was studied in ten dogs. Extr...

We have examined the influence of the sodium channel toxins veratrine and veratridine on μ-opioid ([3H]-DAGO), muscarinic ([3H] NMS) and β-adrenergic ([3H] CGP) receptors in rat brain slices. These drugs reduce opioid and muscarinic binding while leaving β-receptors unaffected. Veratrine is i...

The interactions and mechanisms between veratrine and paeoniflorin on the isolated rat aorta were studied. Veratrine (1×10−6 to 1×10−4g/ml) could induce contraction on the isolated rat aorta in a concentration-related manner. Paeoniflorin had no effect on the isolated rat aorta. Pretreatment w...

It is well known that calcium arsenates may not be a good choice for arsenic removal and immobilization in hydrometallurgical practices. However, they are still produced at some plants in the world due to various reasons. Furthermore, calcium arsenates can also naturally precipitate under some s...

The metal-organic framework (MOF) UiO-66-NH2 was synthesized with different substrate to solvent ratios and its morphology, surface area, pore distributions, and NMR, XRD, and TGA-FTIR patterns were obtained. Adsorption tests at pH 7 and 25 °C showed that the produced UiO-66-NH2 has a hydrogen ...

Natural filtration material tuff (T) was modified by coating with nano-sized magnetite. The grain fraction of 0.6–1.9 mm was submitted to hydrothermal synthesis of magnetite. Thus formed magnetite modified tuff (MMT) was characterized in terms of Fe-content, N2 adsorption- desorption isotherm, ...

A new series of pyrazolo[1,5-a]pyrimidines exemplified by compound 1, has been identified with moderate activity (IC50 = 165 nM), following GSK256066 rescaffolding. Compound 1 optimization at positions 2, 3, 6 and 7 gave compound 10 with high in vitro activity (IC50 = 0.7 nM). Modeling studies b...

Assessment of wildlife exposure to organophosphorus (OP) pesticides generally involves the measurement of cholinesterase (ChE) inhibition, and complementary biomarkers (or related endpoints) are rarely included. Herein, we investigated the time course inhibition and recovery of ChE and carboxyle...

New oxime-derived palladacycles were prepared, spectral characterized, and immobilized on silica gel. Homogeneous catalysis indicates that pyridine coordinated oxime-derived palladacycles 1 and 2 were very effective in the methanolysis of fenitrothion, but suffered from the formation of the inac...

Thermolysis of N-phenylbenzamide oximes I, II and III (R = Cl, NO2 and OCH3) under nitrogen gives rise to benzimidazoles as the major products (45–52%), in addition to benzonitrile, arylamines, benzoic acid, phenols, benzanilides, 2-phenyl benzoxazoles and carbazoles. In the presence of naphtha...

This communication describes synthesis and in vitro evaluation of a series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers as reactivators of sarin inhibited acetylcholinesterase (AChE). The ...

A new and easy-to-perform route to 2-oxazolines amd isoxazolines was reported. Using CuBr2 as both the bromide source and the reaction promoter, bromocyclization of N-allylamides and allyl ketone oximes proceeded readily, leading to oxazolines and isoxazolines in good to excellent yields.

There is an immediate need to develop new strategies for detoxification and decontamination of organophosphorus-containing nerve agents and pesticides. Oximes have witnessed increased scientific interest because of their various applications ranging from acetylcholinesterase reactivators, indepe...

A series of mono pyridinium oximes linked with arenylacetamides as side chains were synthesized and their in vitro reactivation potential was evaluated against human acetylcholinesterase (hAChE) inhibited by organophosphorus inhibitors (OP) such as sarin, VX and tabun. The reactivation data of t...

The concurrent esterification and N-acetylation of amino acids has been studied with triethyl orthoacetate (TEOA) and triethyl orthoformate (TEOF). In a surprising finding, only 1 equiv of TEOA in refluxing toluene was necessary to convert l-proline and l-phenylalanine into the corresponding N-a...

In a previous series of potent GABA uptake inhibitors published from this laboratory, we noticed that asymmetry in the substitution pattern of the bis-aromatic moiety in known GABA uptake inhibitors such as 4 [1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid] and 5 [(R)-1-(4,4-bis(3-methyl...

Publisher SummaryThis chapter discusses the pyrolysis of various derivatives of carboxylic acids. Typical reaction for the pyrolysis of esters that contain hydrogen at the β-carbon in the R2 group from the alcohol moiety forms an acid and an alkene. This reaction takes place by an Ei concerted ...

Escherichia coli 5 s RNA was reacted with 1-cyclohexyl-3-(2-morpholinyl-(4)-ethyl) carbodiimide [14C]methoiodide in the presence of magnesium ion. The RNA molecule seems highly compact in that most of its bases are inaccessible to the carbodiimide. However, the uridine residues in two sequences,...