A new synthesis of dehydroluciferin [2-(6′-hydroxy-2′-benzothiazolyl)-thiazole-4-carboxylic acid], the oxidative product of luciferin, has been realized starting from 1,4-benzoquinone. Reaction of this compound with l-cysteine ethyl ester, followed by an oxidation–cyclization step afforded 2-...

An efficient and diversity oriented one-pot three component sequential synthetic method has been presented for the synthesis of 3-benzothiazolyl-2-styrylquinazolin-4(3H)-ones. The synthetic method involves the reaction of 3,1-benzoxazinone with 2-aminobenzothiazole and subsequently with aromatic...

The series of nickel halide complexes LNiX2 (C1–C6, X = Cl; C7–C12, X = Br), where L represents one of 8-benzoxazolyl-2-alkylquinoline or 8-benzothiazolyl-2-alkylquinoline derivatives, have been prepared. The molecular structures of the representative complexes C1, C3, C6 and C11 were determin...

Dissymmetric chelating complexes of Ti, Zr and V with 2-(benzimidazolyl, benzothiazolyl, and benzoxazolyl) pyridine ligands were synthesized and characterized. After activation with methylalumoxane (MAO) in solution, these complexes could be applied as ethylene polymerization catalysts. Their ac...

A novel, piperidene-catalysed, one-pot synthesis of 3-(2′-benzothiazolyl)coumarins was undertaken, starting from salicylaldehydes, ethyl cyanoacetate and o-aminobenzenethiols in ethanol. Salicylaldehydes with electron-donating group gave optimum yields. The novel method is characterized by mild...

A series of 2-(2-benzothiazolyl)-6-(1-(arylimino)ethyl)pyridines and their metal (Fe or Co) complexes were prepared. All organic compounds were fully characterized by NMR, FT-IR spectra and elemental analysis, and all metal complexes were identified by FT-IR spectroscopic and elemental analysis....

In the present study, we have designed imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives from earlier reported imidazo[1,2-a]pyridine based Mycobacterium tuberculosis (MTB) pantothenate synthetase (PS) inhibitors. We synthesized thirty compounds and they were evaluated for MT...

Efficient and green syntheses of heterocycles are of great importance. In this work, we have demonstrated the synthesis of benzo[d]thiazoles and benzo[d]oxazoles using 2-acylpyridazin-3(2H)-ones as acyl transfer agents under transition-metal-free and eco-friendly conditions. It is worthy to note...

Tuberculosis is the second leading cause of deaths worldwide. The inadequacy of existing drugs to treat TB due to developed resistance and TB-HIV synergism urges for new anti-TB drugs. Seventy-two benzo[d]thiazole-2-carbanilides have been synthesized through CDI-mediated direct coupling of benzo...

Publisher SummaryThis chapter describes the nomenclature and symbolism of α-amino acids. The nomenclature used for α-amino acids in any biochemical context, from proteins to metabolism to bacterial cell walls to antibiotics and hormones, utilizes almost exclusively the trivial names that are c...

Sporadic spike discharges recorded on EEGs from epidural electrodes appeared 5–10 min after topical application of 0.3 nmol ·-guanidinovaleric acid (DGVA) on the pia mater of the sensorimotor cortex, on the same side as the application.Spike discharges induced by DGVA were completely suppresse...

Quaternary ammonium compounds containing N-trimethylamino moiety, such as choline derivatives and carnitine, abundant in meat and dairy products, are metabolic precursors of trimethylamine (TMA). A similar fate is reported for Nε-trimethyllysine and γ-butyrobetaine. With the aim at investigati...

SummaryAlkyl chloroformates (RCF) in aqueous alcohol-pyridine (PYR) media enable amino acids (AAs) to be converted into derivatives amenable to gas chromatography (GC) analysis in seconds. There is no requirement for a dry residue, multiple reaction steps and sample heating. Moreover, the fast c...

The relationship between these factors was studied in plaque and plaque fluid samples taken at intervals during the Stephan pH curve following a sucrose mouth rinse. Levels of lactate rose after the rinse, then fell during the pH recovery phase. Levels of acetate, propionate and phosphate fell a...

1.1. The effects of the alkaloids bicuculline, strychnine, and picrotoxin on the actions of the depressant amino-acids glycine, GABA, β-hydroxy GABA, β-alanine, and δ-amino-valeric acid on neurons of the spinal cord and cerebral cortex of the rat were investigated.2.2. In the spinal cord stry...

This review systematically surveys the viscosity B-coefficients and standard partial molar volumes of amino acids at various temperatures as these data are quite important for interpreting the hydration and other properties of peptides and proteins. The effect of organic solutes and various ions...

All ten of the possible five-carbon acyclic primary β-, γ-, and δ-amino alkanoic acids (amino position isomers of the valines) have been positively identified in hot-water extracts of the Murchison meteorite using combined gas chromatography-mass spectrometry (GC-MS) and ion exchange chromato...

The δD values of over 40 amino acids and two pyridine carboxylic acids of the Murchison and Murray meteorites have been obtained by compound-specific isotopic analyses. For compounds with no known terrestrial distribution, these values range from approximately +330‰ (for cyclic leucine) to +36...

The polymer–electrolyte Wilson model [R. Sadeghi, J. Chem. Thermodyn. 37 (2005) 323–329] which has a molecular thermodynamic framework has been extended to model the vapor–liquid and liquid–solid equilibrium behavior of amino acids and small peptides in aqueous solutions as functions of temp...

2-Nitroaryl aldehydes, ketones, and imines were reductively cyclized to 2,1-benzisoxazoles with good yields in the presence of indium and iodine in MeOH. Under a similar condition, N-(2-nitrobenzylidene)anilines were produced mixtures of 2,1-benzisoxazoles and 3-anilino-2-phenyl-2H-indazoles.