1.1. Evidence is presented that under physiological conditions cysteinyldopa behaves similarly to catecholamines, e.g. adrenaline, in forming reversible complexes with various metallic cations.2.2. As a rule, these complexes are stable under anaerobic conditions, but readily autoxidize in the pr...

5-S-cysteinyldopa is a well-known pigment intermediate and analysis of its plasma concentration is interesting for the early diagnosis, as well as for evaluation of treatment and follow-up of malignant melanoma. A determination method of 5-SCD in human plasma was developed using solid phase extr...

The concentration of dopa, dopamine and cysteinyldopa were measured in various parts of the mature bovine eye, using a fluorescent assay. Special attention was paid to cysteinyldopa levels, since this compound is thought to be a specific marker of melanin turnover. Levels of cysteinyldopa in the...

The first convenient synthesis of 2-S-cysteinyl-3,4-dihydroxyphenylalanine (2-S-cysteinyldopa) in 30% overall yield is reported, which capitalizes on the anomalous regiochemistry of the oxidative coupling of 3,4-dihydroxycinnamic acid derivatives with thiol compounds, leading to 2-S rather than ...

Malignant melanoma originating outside the skin is very rare, whereas primary malignant melanoma of the lung is extremely rare. 5-S-Cysteinyldopa (5-S-CD), a melanin metabolite, has been reported to be a prognostic marker for cutaneous malignant melanoma. This is the first report in the English ...

Pheomelanin and pheomelanin precursors have been implicated as risk factors for induction of melanoma by ultraviolet radiation. The pheomelanin precursor, 5-S-cysteinyldopa, has been shown to sensitise DNA to oxidative damage by ultraviolet radiation. We here show that 5-S-cysteinyldopa signific...

The present study was designed to analyze the effect of Pseudomonas putida Rs-198 (Rs-198) on pepper plant nutrient accumulation and its root environment changes in slightly saline soil field condition at Xinjiang, China. Results showed that the application of Rs-198 increased the pepper biomass...

Electroweak precision tests allow for lighter Kaluza–Klein (KK) Higgs modes in the deformed Randall–Sundrum (RS) model than in models with custodial symmetry. The first KK mode of the Higgs (h1) in such a model could have a mass as low as 900 GeV. In this paper, we study the production of h1 a...

In this work, the potential of COSMO-RS for direct prediction of surface tension through a desolvation-based model is explored. It is shown that for most investigated molecules, the model gives reasonable approximation of the surface tension values without any empirical fitting (average absolute...

Resistant starch (RS) refers to the portion of starch not digested by human digestive enzymes and not enzymatically degraded into glucose in either the mouth or the small intestine, but is subject to bacterial fermentation within the large intestine. A wide variety of health benefits have been a...

The adjustable parameters in the popular conductor-like screening model for real solvents (COSMO-RS) within the Amsterdam density functional (ADF) framework have been re-optimized to fit for the systems containing ionic liquids (ILs). To get the optimal values of misfit energy constant a′, hydr...

Dispersion of asphaltene in crude oil using ionic liquids (ILs) is being considered as a viable solution, in extraction and transportation processes. In this work, the interplay between asphaltene and ILs has been studied systematically to understand the effect of structural variation of ILs on ...

The solubility of ethenzamide (Et) in six organic solvents has been found to be very imprecisely predicted by COSMO-RS approach leading to error of computed mole fractions between 360% for methanol (MeOH) up to 600% in the case of ethyl acetate (EtAc). This paper suggests that the origin of such...

In Computing devices in the world wide, where number of computing and communication systems are increased rapidly. In the channel noise has greater impact on the messages or data transmitted through the wired/wireless network. The Reed-Solomon (RS) decoder plays a vital role in removing the erro...

Deep eutectic solvents (DES) present interesting properties, mostly connected to their solvation ability, and have been subject to much research in the recent past. Currently, the discovery of new eutectic solvents is accomplished by experimentally measuring the eutectic point of random systems,...

ObjectivesPulmonary embolism (PE) is one of the leading causes of cardiovascular mortality worldwide. Electrocardiography (ECG) may provide useful information for patients with acute PE. In this study, we aimed to investigate the diagnostic value of the QRS duration and RS time in inferolateral ...

The photoreactive analog of vasopressin [1,6-α-aminosuberic acid, 3-(p-azidophenylalanine),8-arginine]vasopressin was labeled with tritium (specific radioactivity: 39 Ci/mmole). In the absence of UV-light, the tritium-labeled ligand retained a high binding affinity to the vasopressin receptor i...

In this paper, a new topological descriptor T-scale is derived from principal component analysis (PCA) on the collected 67 kinds of structural and topological variables of 135 amino acids. Applying T-scale to three peptide panels as 58 angiotensin-converting enzyme (ACE) inhibitors, 20 thrombopl...

A cyclic hexapeptide hydroxamic acid inhibitor for HDAC6 has been designed and synthesized on the basis of the facts that α-tubulin is the substrate of HDAC6 and of the excellent inhibitory activity of cyclic tetrapeptide hydroxamic acids (CHAPs) for HDACs. Unexpectedly, cyclic hexapeptide hydr...

Metabolomics has been an evolving science with a wide range of applications in various fields. However, previous studies have rarely focused on metabolite chirality. In this study, to achieve metabolic profiling of chiral amino acids and related metabolites, we developed a high-throughput method...