O- and N-trityl derivatives Ph3C∗-X-R∗ of chiral alcohols (X = O) and amines (X = NH) are known to produce strong and stereochemically predictable Cotton effects in the Electronic Circular Dichroism (ECD) spectra due to the preferred M or P helical conformation of the trityl group. With the use ...

We have coupled S,S′-bis-trityl N-BOC protected 1,2-ethylenedicysteamine, a bis-amino bis-thiol (BAT) tetraligand, via a propylene or ethylene spacer to several biologically active molecules including 2-nitroimidazole, desethylflumazenil, a beta-CIT analogue, glucose and 2-(2′-hydroxy-4′-amin...

A new crystalline N,N′-ditrityl amino amide host included several amide guests in the host cavity to form inclusion crystals. Although the installation of trityl groups into (S)-2-aminopropanamide broke its inherent hydrogen bonds of amide groups, inclusion of guest amides compensated the loss ...

The process of dynamic chirality transmission from permanent chirality element to stereodynamic triphenylmethyl group placed in the distance of 4 bonds, has been studied for series of optically active 3,3,3-triphenylpropionic acid derivatives. Structural analysis, carried out with the use of com...

Condensation reaction of 5-bromo-1H-indole-3-carbaldehyde and 1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione in ethanol under reflux conditions furnished the formation of 5-((5-bromo-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione indole in a very good yield. The desired co...

A wide number of marketed drugs and drug candidates in cancer clinical development contain halogen substituents. The aim of the present study was to synthesize a series of halogen incorporated indole-coumarin hybrid schiff bases - N′-((2-(2-oxo-2H-chromen-3-yl)-1H-indol-3-yl)methylene)benzohydr...

A mild and highly efficient method has been developed for the synthesis of unsymmetrical 2,2-di(1H-indol-3-yl)-N-phenylacetamide derivatives by the regioselective Friedel–Crafts alkylation of 2-hydroxy-2-(1H-indol-3-yl)-N-phenylacetamide derivatives with various indoles catalyzed by AlCl3 at ro...

The chief purpose of this work was to synthesise and find out the anti-oxidant and anti-microbial activities of novel 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1-one chalcone derivatives. These derivatives were prepared by performing Claisen–Schmidt condensation reaction of 1-(...

Sulfonamides are the most famous agents, which have been utilized for preparation of effective antiproliferated agents. Therefore, this article describes the synthesis of new series of N-ethyl-N-methylbenzenesulfonamide derivatives having various biologically active moieties such as, thiazoles 3...

In the present work, molecular structures and intramolecular hydrogen bonding (IHB) of 3-methyl-4-amino-3-penten-2-one, 3-MeAPO, 3-methyl-4-methylamino-3-penten-2-one, 3-Me-MeAPO, and the 3-methyl-4-phenylamino-3-penten-2-one, 3-Me-PhAPO have been investigated by means of density functional theo...

A series of 10 new N-phenyl-4-(4-(thiazol-2-yl)-phenyl)-thiazol-2-amine derivatives (3a–j) and 4 new 5-(2-(phenylamino)-thiazol-4-yl)-benzamide ethers (3′a–d) were synthesized from 4-(2-phenylamino)-thiazol-4-yl)-benzothioamide and 2-hydroxy-5-(2-(phenylamino)-thiazol-4-yl)-benzamide with sev...

Leishmaniasis is a group of diseases caused by protozoan parasites from the genus Leishmania. There are estimated 1.3 million new cases annually with a mortality of 20,000–30,000 per year, when patients are left untreated. Current chemotherapeutic drugs available present high toxicity and low e...

Mannich bases 2-(3-Phenylaminopropionyloxy)-benzoic acid (A) and 3-Phenylamino-1-(2,4,6-trimethoxy-phenyl)-propan-1-one (B) were synthesized. Structures were confirmed by ultraviolet/visible and infra-red spectroscopies. The ionization constant (pKa) values at 8.3 and 8.0 reported for compounds ...

The structure of a newly synthesized 3-methylthio-4-phenyl-5-phenylamino-1,2,4-triazole 1 and its hexabromotellurate salt 2 was investigated. The X-ray diffraction study of 2 gives the insight on the different interaction types in the crystal. The DFT calculations were used for the comprehensive...

Two new homologous series of Cu(II) and Pd(II) complexes with benzothiazole-cored Schiff bases have been synthesised with the aim to study the mesomorphic and thermal properties of ligands upon formation of metal complexes. The molecular structure of title compounds were elucidated with the empl...

2,3,9,10,16,17,23,24-Octakis(phenoxy)phthalocyaninato manganese complex MnCl[Pc(OPh)8] (1) was prepared and spectroscopically and electrochemically characterized. For the comparative reason, 2,3,9,10,16,17,23,24-octakis(octyloxy) phthalocyaninato manganese analogue MnCl[Pc(OC8H17)8] (2) was also...

The optical power limiting performances for eight-β-octa-octyloxy phthalocyanines with initial linear transmission T0=88–92% at 532 nm in a 0.5 cm spectroscopic cell in toluene have been measured with 35 ps pulses, in which eight-β-octa-octyloxy phthalocyanine free-base exhibits the strongest...

Benzooxadiazole containing three monomers; 5,6-bis(octyloxy)-4,7-bis(4-hexylthiophen-2-yl)-2,1,3-benzoxadiazole (BOHT), 5,6-bis(octyloxy)-4,7-di-2-thienyl-2,1,3-benzoxadiazole (BODT) and 5,6-bis(octyloxy)-4,7-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2,1,3-benzoxadiazole (BODHT) were synthes...

The third order nonlinear optical properties of the eight-β-octa-octyloxy-phthalocyanines in chloroform were investigated by Z-scan using ps laser at 532 nm. The excited state absorption cross section and the nonlinear refractive cross-section were determined. Eight-β-octa-octyloxy-phthalocyan...

An interesting phenomenon was that some symmetrically substituted metal phthalocyanines behaved characteristic absorption band split in non-coordinated solvents especially when they had zinc as the center metal and alkyloxy substituted groups at non-periphery of molecular skeleton, for example t...