The preventive effects of TQS169 peptide on osteoporosis were investigated and the mechanisms of promoting osteogenic differentiation and calcium absorption were also studied in vitro and vivo in this research. Wistar rats were given a low-Calcium diet treated with different doses of peptide TQS...

Materials currently used for the treatment of bone defects include ceramics, polymeric scaffolds and composites, which are often impregnated with recombinant growth factors and other bioactive substances. While these materials have seen instances of success, each has inherent shortcomings includ...

The aim of this work was the preparation of inorganic mesoporous materials from silica, calcium phosphate and a nonionic surfactant and to evaluate the incorporation and release of different concentrations of osteogenic growth peptide (OGP) for application in bone regeneration. The adsorption an...

Poly(d,l-lactic acid) (PDLLA) is widely used for bone regenerative engineering, because of its proven biocompatibility and biodegradability. However, the major limitation of PDLLA is its cell recognition and low hydrophilicity. The objective of this study was to develop a novel bioactive poly(d,...

The surface-inspirable biomaterials have captured extensive attention in simulating microenvironments by mimicking nanoscale architectures and signal molecules in the extracellular matrix (ECM). To activate osteogenic differentiation through biomimetic nanostructures, osteoid-like calcium titana...

Nanocomposite layers of mineral/osteogenic growth peptide (OGP) were synthesized on calcium phosphate coated titanium substrates by immersing in calcium-phosphate buffer solution containing OGP. Peptide incorporated mineral was characterized by determining quantity loaded, effects on mineral mor...

The aim of present study was to characterize long non-coding RNA (lncRNA) AK141205 as a cellular regulator of osteogenic differentiation of mice mesenchymal stem cells (MSCs) towards osteogenic growth peptide (OGP) stimulation. Mice MSCs cells were isolated, transfected with si-AK141205, pcDNA-A...

Despite advances in the field of biomaterials for bone repair/regeneration, some challenges for developing an ideal bone substitute need to be overcome. Herein, this study synthesized and evaluated in vitro a nanocomposite based on bacterial cellulose (BC), collagen (COL), apatite (Ap) and osteo...

To investigate the influence of surface-biofunctionalized substrates on osteoblast behavior, a layer of aligned TiO2 nanotubes with a diameter of around 70 nm was fabricated on titanium surface by anodization, and then osteogenic growth peptide (OGP) was conjugated onto TiO2 nanotubes through th...

Poly(3-hydroxybutyrate) (PHB) is a biodegradable and thermoprocessable biopolymer, making it a promising candidate for applications in tissue engineering. In the present study a structural characterization and in vitro evaluation were performed on PHB scaffolds produced by additive manufacturing...

Discharges from industrial cooling water systems can include low levels of morpholine (a chemical pH regulator and corrosion inhibitor), as well as transiently higher temperature effluent water which present a potential source of environmental impact to aquatic biota. The effects of environmenta...

Densities, ρ, and viscosities, η, of aqueous solutions of N-(2-hydroxyethyl)morpholine were measured over the entire composition range at T = (293.15, 303.15, 313.15, 323.15, 333.15) K and at atmospheric pressure. The excess molar volumes VE and viscosity deviations ηE of aqueous solutions we...

Aqueous monoethanolamine (MEA) has been used as benchmark solvent in CO2 capture systems due to its fast absorption kinetics, high cyclic capacity and low cost. However, operational challenges make MEA potentially less attractive, and therefore; there has been a high demand to develop new solven...

Two new caffeic acid ester derivatives, caffeic acid-4-(2-hydroxyethyl) morpholine ester (Z-1) and caffeic acid-4-(3-hydroxypropyl) morpholine ester (Z-2), were synthesized, and their structures were characterized by LC–MS, IR, and 1H NMR. The activation effects of the two compounds on tyrosina...

N-(2-hydroxyethyl)morpholine betaine (HEMB) has been characterized by a single crystal X-ray analysis, FTIR spectroscopy and DFT calculations. The crystals are monoclinic, space group P21/c with a=10.273(2), b=9.360(2), c=9.447(2) Å and β=104.72(3)Å. Two molecules of HEMB form a centrosymmetric...

Densities of binary mixtures of N-(2-hydroxyethyl)morpholine with ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol were measured over the entire composition range at temperatures from (293.15 to 323.15) K and atmospheric pressure using a vibrating-tube densimeter. The excess molar volum...

The 1H, 13C and 15N NMR spectra of N-(2-hydroxyethyl)-morpholine (1), N-(2-hydroxyethyl)-morpholinium chloride (2), N-(2-hydroxyethyl)-morpholine betaine (3), N-morpholinyl-spiro-morpholactone chloride (4) and N-morpholinyl-spiro-morpholactone picrate (5) have been recorded and analyzed. The inf...

The optimized geometry and vibrational frequencies of 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-ylimino)-2-(4-nitro-phenyl) acetonitrile (DOPNA) were obtained by ab initio DFT/B3LYP level with complete relaxation in the potential energy surface using 6-31G and 6-311G basis sets. Th...

The reactions of 3-nitro-2-phenyl-2H-chromenes with 2-arylmethylidene-5-oxopyrazolidin-2-ium-1-ides proceeded diastereoselectively to afford the corresponding tetrahydrochromeno[4,3-c]pyrazolo[1,2-a]pyrazol-11-ones in good yields as a result of the 1,3-dipolar cycloaddition reaction of stabilise...

A simple, two step strategy consisting of Sharpless asymmetric dihydroxylation followed by regioselective breaking of CO bond is utilized to target key chiral intermediates of natural products virolongin B, kigelin, kurasoin A, 4-hydroxy-sattabacin, and actinopolymorphol A. Derivatives of enanti...